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Bioinformatics

Head: Dr Mark Ziemann

Helping Burnet's researchers extract meaningful results from their data. We provide training, consultation and data analysis services. We also conduct meta-research to improve the reliability of bioinformatics.

Life science and public health are becoming more data-driven disciplines. Advances in genomic sequencing and other ‘omics means researchers need to be skilled in working with large datasets to extract meaningful results.

Our group's main aim is to enhance the data analytics capacity of the Institute. We achieve this through:

  • one-on-one training sessions, workshops and provision of learning materials
  • working directly with other working groups at the institute
  • providing consultation and conducting data analysis.

We are developing data resources and software tools to help researchers extract usable information from their raw data sets. 

Our group are also conducting meta-research to improve the reliability of bioinformatics.

Our group is skilled in analysing DNA sequencing data. This data is used to understand the effect of mutations, trace disease outbreaks, and how genes are switched on and off. 

We specialise in integrating complex data types, including protein expression, epigenetics and metabolic datasets. We provide data analytics skills and expertise to many working groups across Burnet.

Our work on research reliability involves systematic assessments of published research works to understand whether they are reproducible and have used validated methods.

Our work helps accelerate the development of therapies and evidence-based recommendations across the institute.

Dr Mark Ziemann

Mark is a bioinformatician with over 10 years experience in the analysis of genomics data.

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Projects

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Towards reliable pathway enrichment
PROJECT Towards reliable pathway enrichment
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Harnessing Natural Killer cells to eliminate HIV
PROJECT Harnessing Natural Killer cells to eliminate HIV
The persistence of HIV in macrophages - a barrier to HIV cure
PROJECT The persistence of HIV in macrophages - a barrier to HIV cure
Getting to the heart of cardiovascular disease in viral infections
PROJECT Getting to the heart of cardiovascular disease in viral infections
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A novel gel for targeting vaginal inflammation to prevent HIV transmission
PROJECT A novel gel for targeting vaginal inflammation to prevent HIV transmission
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Impact of a vaginal microbiota metabolite on epithelium integrity and HIV susceptibility
PROJECT Impact of a vaginal microbiota metabolite on epithelium integrity and HIV susceptibility
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Antimicrobial and immune modulatory effects of vaginal microbiota metabolites
PROJECT Antimicrobial and immune modulatory effects of vaginal microbiota metabolites
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Identifying risk factors and biomarkers of post-acute sequelae COVID-19 (PASC, Long COVID)
PROJECT Identifying risk factors and biomarkers of post-acute sequelae COVID-19 (PASC, Long COVID)