To determine if temporarily withdrawing specific immunosuppressants can enhance vaccine immune responses in people living with SLE.
2023 - Ongoing
In collaboration with clinicians at Monash Health we will be performing an intervention study testing if withdrawal of Mycophenolate, for 2 weeks, improves immune responses to seasonal influenza vaccination compared to patients who remain on Mycophenolate. The Antiviral Immunity team will measure serological and cellular responses to seasonal influenza vaccinations.
Immunogenicity and safety of vaccination in SLE patients has been of significant interest to clinicians, but limited data are available. We anticipate that SLE patients who have had temporary interruption of immunosuppression will have improved antibody responses. The findings from this study will be used to develop new evidence-based guidelines to improve clinical care of SLE patients.
Doctor Gabriela Khoury
Contact Doctor Gabriela Khoury for more information about this project.
Funding
Partners
- Arthritis Australia
- Burnet Institute
Partners +
Collaborators
- Monash Health: A/Prof Alberta Hoi, A/Prof Ian Woolley and A/Prof Claire Dendle.
Project
Team
Meet the project team. Together, we are translating research into better health, for all.
