- To evaluate if the treat-all approach to managing hepatitis B-infected pregnant women leads to a reduction in hepatitis B among infants compared to a guideline-based care approach;
- To evaluate and compare the acceptability, cost-effectiveness and safety of the treat-all and guideline-based care approaches to management of hepatitis B-infected pregnant women.
2023 - 2025
A two-arm, parallel group, randomised trial with hepatitis B-infected pregnant women attending antenatal clinics in Port Vila, Vanuatu. Infants will be tested 6-12 months after birth.
The treat-all approach is highly novel and will facilitate a major paradigm shift in prevention of mother-to-child transmission of hepatitis B in low and low-middle income countries including Pacific Island Countries.
Pacific regional stakeholders will be consulted to determine the best strategy for regional roll-out of updated guidance.
The impact of the intervention will be immediate in terms of averting hepatitis B infections in infants in Vanuatu. Scale-up of the intervention across the Pacific could avert hundreds of infections each year.
Funding
Partners
- Thrasher Research Fund
Partners +
Collaborators
- Vanuatu Ministry of Health
- Doherty Institute
- VIDRL
Project
Team
Meet the project team. Together, we are translating research into better health, for all.
