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Tetraspanins-structural and signalling scaffolds that regulate platelet function.

Goschnick MW, Jackson DE

  • Journal Mini reviews in medicinal chemistry

  • Published 07 Mar 2008

  • Volume 7

  • ISSUE 12

  • Pagination 1248-54

  • DOI 10.2174/138955707782795656


There are several tetraspanins present in platelets including CD9, CD151, TSSC6, and CD63. Recent studies in knockout mouse models have revealed that CD151 and TSSC6 are physically and functionally involved in regulation of the 'outside-in' signalling properties of the major platelet integrin, integrin alpha(IIb)beta(3) and thrombus stability in vivo.