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Revealing the molecular determinants of gender in malaria parasites.

Cowman AF, Crabb BS

  • Journal Cell

  • Published 19 Jul 2005

  • Volume 121

  • ISSUE 5

  • Pagination 659-60

  • DOI 10.1016/j.cell.2005.05.014


Malaria parasites have a complex life cycle with asexual multiplication in a vertebrate host and obligate sexual reproduction in the mosquito; however, commitment to sexual development begins in the vertebrate with differentiation of female and male gametocytes. In this issue of Cell, Khan et al. (2005) used elegant approaches to purify male and female gametocytes and elucidated their respective proteome, providing the basis for understanding sexual development in this pathogen.