close Icon

Receptor-specific delivery of protein antigen to dendritic cells by a nanoemulsion formed using top-down non-covalent click self-assembly.

Zeng BJ, Chuan YP, O'Sullivan B, Caminschi I, Lahoud MH, Thomas R, Middelberg AP

  • Journal Small (Weinheim an der Bergstrasse, Germany)

  • Published 18 Apr 2013

  • Volume 9

  • ISSUE 22

  • Pagination 3736-42

  • DOI 10.1002/smll.201300078


A new class of targeted and immune-evading nanocarrier made using only biological components and facile processes is assembled in a bottom-up fashion. Simple top-down sequential addition of immune-evading or receptor-specific antibody elements conjugated to biosurfactant protein DAMP4 promotes self-assembly at an interface previously formed in the presence of peptide surfactant AM1, leading to a functional display at the interface through non-covalent molecular self-assembly.