close Icon

Protein disulfide isomerases - a way to tackle malaria.

Angrisano F, Ford A, Blagborough AM, Bullen HE

  • Journal Trends in Parasitology

  • Published 09 Jun 2023

  • Volume Epub ahead of print

  • DOI


Protein disulfide isomerases (PDIs) ensure that specific substrate proteins are correctly folded. PDI activity plays an essential role in malaria transmission. Here we provide an overview of the role of PDIs in malaria-causing Plasmodium parasites and outline why PDI inhibition could be a novel way to treat malaria and prevent transmission.

Keywords: inhibition; malaria; protein disulfide isomerase.