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Dimeric immunoglobulin A as a novel diagnostic marker of measles infection.

Mohd Hanafiah K, Hiebert J, Zubach V, Severini A, Anderson DA, Drummer HE.

  • Published 11 Dec 2023

  • Volume 12

  • ISSUE 1

  • Pagination e0343723

  • DOI 10.1128/spectrum.03437-23


The world is facing a measles resurgence, and improved diagnostic tests for measles infection are an urgent World Health Organization research priority. Detection of measles-specific immunoglobulin M (IgM) as a standard diagnostic test has low positive predictive value in elimination settings, and there is a need for new biomarkers of measles infection to enable enhanced surveillance and response to outbreaks. We demonstrate the detection of measles-specific dimeric immunoglobulin A (dIgA) in patients with confirmed measles infections using a new indirect enzyme-linked immunosorbent assay protocol that selects for the dIgA fraction from total IgA in the blood. The magnitude of measles-specific dIgA responses showed a low correlation with IgM responses, and our results highlight the potential of dIgA for further development as an alternative and/or complementary biomarker to IgM for serological diagnosis of measles infection.