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Transthyretin (prealbumin) gene expression in choroid plexus is strongly conserved during evolution of vertebrates.

Harms PJ, Tu GF, Richardson SJ, Aldred AR, Jaworowski A, Schreiber G

  • Journal Comparative biochemistry and physiology. B, Comparative biochemistry

  • Published 03 Jan 1992

  • Volume 99

  • ISSUE 1

  • Pagination 239-49

  • DOI 10.1016/0305-0491(91)90035-c


1. The major protein synthesized and secreted by the choroid plexus from mammals, birds, reptiles and probably amphibians is similar in subunit structure to transthyretin. 2. In mammals and birds the proportion of transthyretin mRNA is much higher in choroid plexus RNA than in liver RNA. No transthyretin mRNA is found in brain outside the choroid plexus. 3. Transthyretin-like protein, such as that secreted by the choroid plexus, was not detected in amphibian serum and was present in very low levels in reptile serum. 4. It is proposed that transthyretin synthesis and secretion arose earlier in evolution in the choroid plexus than in the liver.