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Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon.

Crabb BS, de Koning-Ward TF, Gilson PR

  • Journal BMC biology

  • Published 31 Mar 2011

  • Volume 9

  • Pagination 21

  • DOI 10.1186/1741-7007-9-21


The ability to analyze gene function in malaria-causing Plasmodium parasites has received a boost with a recent paper in BMC Genomics that describes a genome-wide mutagenesis system in the rodent malaria species Plasmodium berghei using the transposon piggyBac. This advance holds promise for identifying and validating new targets for intervention against malaria. But further improvements are still needed for the full power of genome-wide molecular genetic screens to be utilized in this organism.See research article: