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Sequence and structure relatedness of matrix protein of human respiratory syncytial virus with matrix proteins of other negative-sense RNA viruses.

Latiff K, Meanger J, Mills J, Ghildyal R

  • Journal Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

  • Published 02 Dec 2004

  • Volume 10

  • ISSUE 10

  • Pagination 945-8

  • DOI 10.1111/j.1469-0691.2004.00980.x


Matrix proteins of viruses within the order Mononegavirales have similar functions and play important roles in virus assembly. Protein sequence alignment, phylogenetic tree derivation, hydropathy profiles and secondary structure prediction were performed on selected matrix protein sequences, using human respiratory syncytial virus matrix protein as the reference. No general conservation of primary, secondary or tertiary structure was found, except for a broad similarity in the hydropathy pattern correlating with the fact that all the proteins studied are membrane-associated. Interestingly, the matrix proteins of Ebola virus and human respiratory syncytial virus shared secondary structure homology.