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Induction of CD8+ T cells using heterologous prime-boost immunisation strategies.

Schneider J, Gilbert SC, Hannan CM, Dégano P, Prieur E, Sheu EG, Plebanski M, Hill AV

  • Journal Immunological reviews

  • Published 22 Dec 1999

  • Volume 170

  • Pagination 29-38

  • DOI 10.1111/j.1600-065x.1999.tb01326.x


One of the current challenges in vaccine design is the development of antigen delivery systems or vaccination strategies that induce high protective levels of CD8+ T cells. These cells are crucial for protection against certain tumours and intracellular pathogens such as the liver-stage parasite of malaria. A liver-stage malaria vaccine should therefore include CD8+ T-cell-inducing components. This review provides an overview of prime-boost immunisation strategies that result in protective CD8+ T-cell responses against malaria with an emphasis on work from our laboratory. Possible mechanisms explaining why heterologous prime-boost strategies, in particular boosting with replication-impaired recombinant poxviruses, are so effective are discussed.