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Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice.

Lees CJ, Apostolopoulos V, Acres B, Ramshaw I, Ramsay A, Ong CS, McKenzie IF

  • Journal Vaccine

  • Published 12 Oct 2000

  • Volume 19

  • ISSUE 2-3

  • Pagination 158-62

  • DOI 10.1016/s0264-410x(00)00065-7


Mice immunised with oxidised mannan-MUC1 fusion protein (M-FP) develop MHC restricted CD8(+) cytotoxic T cells. We now demonstrate that in MUC1/HLA-A2 transgenic mice, IL-12 gives enhanced CTL, CTLp and tumor protection. CTLp in MUC1 transgenic mice with M-FP were 1/55,000, and with IL-12, this increased to 1/19,000, with improved tumor protection. Thus, IL-12 is important for effective CTL responses to MUC1 in transgenic mice.