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HIV persistence: chemokines and their signalling pathways.

Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR

  • Journal Cytokine & growth factor reviews

  • Published 28 Jun 2012

  • Volume 23

  • ISSUE 4-5

  • Pagination 151-7

  • DOI 10.1016/j.cytogfr.2012.05.002


Latently infected resting CD4+ T cells are the major barrier to curing HIV. We have recently demonstrated that chemokines, which bind to the chemokine receptors CCR7, CXCR3 and CCR6, facilitate efficient HIV nuclear localisation and integration in resting CD4+ T cells, leading to latency. As latently infected cells are enriched in lymphoid tissues, where chemokines are highly concentrated, this may provide a mechanism for the generation of latently infected cells in vivo. Here we review the role of chemokines in HIV persistence; the main signalling pathways that are involved; and how these pathways may be exploited to develop novel strategies to reduce or eliminate latently infected cells.