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HIV-1 infection of monocyte-derived macrophages reduces Fc and complement receptor expression.

Kent SJ, Stent G, Sonza S, Hunter SD, Crowe SM

  • Journal Clinical and experimental immunology

  • Published 28 Apr 1994

  • Volume 95

  • ISSUE 3

  • Pagination 450-4

  • DOI 10.1111/j.1365-2249.1994.tb07017.x


Fc receptor (FcR) and complement receptor (CR) expression on HIV-infected monocyte-derived macrophages may be an important determinant of immune function. We studied the effects of HIV-1 infection of macrophages in vitro on FcR and CR expression. Macrophages were infected with HIV-1DV 7 days following isolation, and the expression of Fc gamma RI-III and CR3 were measured at intervals thereafter by flow cytometry. We found a reduction in receptor expression with the percentage of cells expressing FcRI 14 days post infection declining from 77% to 13%, FcRII fell from 96% to 85%, FcRIII from 45% to 9%, and CR3 from 91% to 67% 14 days following infection. As these receptors are important for macrophage function, their down-modulation may contribute to the pathogenesis of HIV-related disease.