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Do apicomplexan parasite-encoded proteins act as both ligands and receptors during host cell invasion?

Gilson PR, Crabb BS

  • Journal F1000 biology reports

  • Published 26 Aug 2009

  • Volume 1

  • Pagination 64

  • DOI 10.3410/B1-64


Apicomplexan parasites are responsible for a wide range of diseases in animals, including humans, in whom Plasmodium species cause the devastating disease malaria. Several recent discoveries now indicate that these intracellular parasites may use a conserved mechanism to infect their host cells by using parasite-encoded proteins as both parasite ligands and receptors anchored to the host cells.