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Clinical practice patterns on the use of magnesium sulphate for treatment of pre-eclampsia and eclampsia: a multi-country survey.

Long Q, Oladapo OT, Leathersich S, Vogel JP, Carroli G, Lumbiganon P, Qureshi Z, Gülmezoglu AM, WHO Multicountry Survey on Maternal and Newborn Health Research Network

  • Journal BJOG : an international journal of obstetrics and gynaecology

  • Published 24 Nov 2016

  • Volume 124

  • ISSUE 12

  • Pagination 1883-1890

  • DOI 10.1111/1471-0528.14400


) for eclampsia prevention and treatment in a multi-country network of health facilities and compare with international recommendations.

Cross-sectional survey.

A total of 147 health facilities in 15 countries across Africa, Latin America and Asia.

Heads of obstetric departments or maternity units.

Anonymous online and paper-based survey conducted in 2015.

dosing regimens for eclampsia prevention and treatment.

was used for the treatment of mild pre-eclampsia, severe pre-eclampsia and eclampsia in 24.3%, 93.5% and 96.4% of all facilities, respectively. Regarding the treatment of severe pre-eclampsia, 26.4% and 7.0% of all facilities reported using dosing regimens that were consistent with Zuspan and Pritchard regimens, respectively. Across regions, intramuscular maintenance regimens were more commonly used in the African region (45.7%) than in the Latin American (3.0%) and Asian (22.9%) regions, whereas intravenous maintenance regimens were more often used in the Latin American (94.0%) and Asian (60.0%) regions than in the African region (21.7%). Similar patterns were found for the treatment of eclampsia across regions.

for eclampsia prevention and treatment varied widely, and was largely inconsistent with current international recommendations.

regimens for eclampsia prevention and treatment in many hospitals are inconsistent with international recommendations.