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A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients.

Wadley AL, Kamerman PR, Chew CS, Lombard Z, Cherry CL, Price P

  • Journal Molecular immunology

  • Published 16 Mar 2013

  • Volume 55

  • ISSUE 3-4

  • Pagination 197-9

  • DOI 10.1016/j.molimm.2013.02.002


Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort.

342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy.

IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association.

We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation.