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Nonplasmacytoid, high IFN-α-producing, bone marrow dendritic cells.

O'Keeffe M, Fancke B, Suter M, Ramm G, Clark J, Wu L, Hochrein H

  • Journal Journal of immunology (Baltimore, Md. : 1950)

  • Published 14 Mar 2012

  • Volume 188

  • ISSUE 8

  • Pagination 3774-83

  • DOI 10.4049/jimmunol.1101365


Plasmacytoid dendritic cells (pDC) are the producers of type I IFNs in response to TLR9 ligands. However, we have found that when bone marrow is depleted of pDC, the IFN-α produced in response to TLR9 ligands is not fully removed. We assign the source of this non-pDC IFN-α as a newly described DC type. It displays the high IFN-α producing activity of pDC but to a more limited range of viruses. Unlike pDC, the novel DC display high T cell stimulation capacity. Moreover, unlike mouse pDC, they are matured with GM-CSF and are less prone to apoptosis upon activation stimuli, including viruses. We propose that these DC constitute a novel bone marrow inflammatory DC type, ideally geared to linking innate and adaptive immune responses in bone marrow via their potent IFN-α production and high T cell stimulatory capacity.