Assessing Drug Consumption Rooms and Longer Term (5 Year) Impacts on Community and Clients.
Tran V, Reid SE, Roxburgh A, Day CA
COVID-19
COVID-19 vaccination perceptions and intentions of maternity care consumers and providers in Australia.
Bradfield Z, Wynter K, Hauck Y, Sweet L, Wilson AN, Szabo RA, Vasilevski V, Kuliukas L, Homer CSE
COVID-19
The global and regional burden of sexual behaviors and food insecurity and their combined association on the magnitude of suicidal behaviors among 121,248 adolescent girls: An international observational study in 67 low- and middle-income and high-income countries.
Mahumud RA, Rahman MA, Gow J, Kamara JK, Koly KN, Shahjalal M, Law CK, Hossain MG, Renzaho AMN
Keeping the host alive - lessons from obligate intracellular bacterial pathogens.
Mammals have evolved sophisticated host cell death signaling pathways as an important immune mechanism to recognize and eliminate cell intruders before they establish their replicative niche. However, intracellular bacterial pathogens that have co-evolved with their host have developed a multitude of tactics to counteract this defense strategy to facilitate their survival and replication. This requires manipulation of pro-death and pro-survival host signaling pathways during infection. Obligate intracellular bacterial pathogens are organisms that absolutely require an eukaryotic host to survive and replicate, and therefore they have developed virulence factors to prevent diverse forms of host cell death and conserve their replicative niche. This review encapsulates our current understanding of these host-pathogen interactions by exploring the most relevant findings of Anaplasma spp., Chlamydia spp., Rickettsia spp. and Coxiella burnetii modulating host cell death pathways. A detailed comprehension of the molecular mechanisms through which these obligate intracellular pathogens manipulate regulated host cell death will not only increase the current understanding of these difficult-to-study pathogens but also provide insights into new tools to study regulated cell death and the development of new therapeutic approaches to control infection.