Background

Steve Graham is a paediatrician with 20 years of clinical and research experience in international child health in African and Asia-Pacific regions. Particular interests include child tuberculosis, pneumonia and invasive bacterial disease especially invasive salmonellosis in tropical Africa. Steve completed his PhD on the impact of HIV on respiratory disease in Malawian children, which included two first-author Lancet publications. His particular current research interest is to improve implementation of child TB management and prevention in the resource-limited setting.

Since returning to Australia in 2008, Steve has developed collaborative links in Asian-Pacific region, including research projects in Indonesia, Bangladesh and Vietnam. Steve has provided technical assistance on child TB to National TB control Programmes in the region including Indonesia, The Philippines, Lao PDR, Myanmar, China and PNG. He works closely with the World Health Organization in the development of international guidelines and training tools for the management of child TB.

Appointments

• 2014- Senior Principal Research Fellow, Burnet Institute, Melbourne
• 2013- Professor of International Child Health, University of Melbourne
• 2011- Honorary Fellow, Menzies School of Health Research, Northern Territory
• 2009- Honorary Consultant Paediatrician, Royal Children’s Hospital
• 2009- Paediatric consultant, North Richmond Community Health
• 2008- Consultant in Child Lung Health, International Union Against Tuberculosis and Lung Disease
• 2008- Honorary Research Fellow and Group Leader, International Child Health, Murdoch Childrens Research Institute
• 2008- Honorary Senior Lecturer, School of Tropical Medicine, University of Liverpool, UK
• 2008- Associate Professor of International Child Health, University of Melbourne

Professional Affiliations

World Health Organization:

• 2011: Chair, Stop TB Partnership Child TB subgroup
• 2003-2011: Vice-chair, Stop TB Partnership Child TB subgroup
• 2012: Member, Strategic and Technical Advisory Group for Tuberculosis
• 2014: Chair, Western Pacific Regional Taskforce on child tuberculosis

National Institutes of Health, USA:

• 2011-14: Member, IMPAACT Tuberculosis Scientific Committee

International Union Against Tuberculosis and Lung Disease, France:

• 1998: Member
• 1999-2004: Programme Secretary, Lung Health Section
• 2004-2005: Vice-Chairman, Lung Health Section
• 2005-2010: Chairman, Lung Health Section

• 2007-2010: Board Member

• 2013: Member, Wellcome Trust/MRC Joint Global Health Trials Committee

• 2009: Paediatric TB representative, National Tuberculosis Advisory Committee, Australia
• 2006: Member, European Society of Paediatric Infectious Disease
• 1998: Member, Royal Society of Tropical Medicine and Hygiene

Positions

• 2001-7 :Clinical Research Fellow and Deputy Director, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine University of Malawi, Malawi
• 2001-7: Senior Clinical Lecturer, Liverpool School of Tropical Medicine, UK
• 2000: Research Fellow, Department of Medical Microbiology and Genitourinary Medicine, University of Liverpool, UK
• 1999: Thomas Marks Fellow, Liverpool School of Tropical Medicine, UK
• 1999: Locum Medical Officer, Karonga Prevention Study (Wellcome Trust and London School of Hygiene and Tropical Medicine) Chilumba, Malawi
• 1997-98 : Senior Lecturer in Paediatrics: College of Medicine, University of Malawi
• 1995-96 : Lecturer in Paediatrics: College of Medicine, University of Malawi, Malawi
• 1993-96: Lecturer in Tropical Child Health: Liverpool School of Tropical Medicine, UK

Qualifications

• 1981: MB BS, University of Sydney, Australia
• 1992: FRACP, Royal Australasian College of Physicians, Australia
• 1993: Diploma in Tropical Child Health, University of Liverpool, UK – Distinction
• 2010: PhD, University of Amsterdam, The Netherlands

Awards

From Liverpool School of Tropical Medicine:

• Cicely Williams Memorial Medal: 1993
• Leverhulme Medal for distinguished contribution to tropical medicine: 2007

Projects (2)

Current (2)

• Healthy Mothers, Healthy Babies
  A collaborative research program aimed at providing life-saving health care for women and children in PNG.
• RID-TB: Reducing the Impact of Drug-Resistant TB in Western Province, PNG
  The project supports an effective provincial program to reduce the impact of TB in Daru.

Publications (27)

2017 (1)

• The management of infection with Mycobacterium tuberculosis in young children post-2015: an opportunity to close the policy-practice gap.
  Graham SM
  Expert Rev Respir Med. 2017 Jan; 11(1):41-49

2016 (1)

• Childhood TB: can the End TB Strategy deliver?
  Seddon JA, Graham SM
  Trans R Soc Trop Med Hyg. 2016 Mar; 110(3):155-157

2015 (8)

• Counting children with tuberculosis: why numbers matter.
  Seddon JA, Jenkins HE, Liu L, Cohen T, Black RE, Vos T, Becerra MC, Graham SM, Sismanidis C, Dodd PJ
  Int J Tuberc Lung Dis. 2015 Dec; 19(Suppl 1):S9-S16
• The background and rationale for a new fixed-dose combination for first-line treatment of tuberculosis in children.
  Graham SM, Grzemska M, Gie RP
  Int J Tuberc Lung Dis. 2015 Dec; 19 Suppl 1:S3-S8
• Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children: An Update.
  Graham SM, Cuevas LE, Jean-Philippe P, Browning R, Casenghi M, Detjen AK, Gnanashanmugam D, Hesseling AC, Kampmann B, Mandalakas A, Marais BJ, Schito M, Spiegel HM, Starke JR, Worrell C, Zar HJ
  Clin Infect Dis. 2015 Oct; 61(suppl 3):S179-S187
• A Blueprint to Address Research Gaps in the Development of Biomarkers for Pediatric Tuberculosis.
  Nicol MP, Gnanashanmugam D, Browning R, Click ES, Cuevas LE, Detjen A, Graham SM, Levin M, Makhene M, Nahid P, Perez-Velez CM, Reither K, Song R, Spiegel HM, Worrell C, Zar HJ, Walzl G
  Clin Infect Dis. 2015 Oct; 61(suppl 3):S164-S172
• Tuberculosis as a cause or comorbidity of childhood pneumonia in tuberculosis-endemic areas: a systematic review.
  Jacquie N Oliwa, Jamlick M Karumbi, Ben J Marais, Shabir A Madhi, Stephen M Graham
  Lancet Respir Med. 2015 Mar; 3(3):235-243
• Risk of infection and disease with Mycobacterium tuberculosis among children identified through prospective community-based contact screening in Indonesia.
  Rina Triasih, Colin Robertson, Trevor Duke, Stephen M Graham
  Trop Med Int Health. 2015 Feb; Epub ahead of print
• Morbidity and mortality in hospitalised neonates in central Vietnam.
  Hoang T Tran, Lex W Doyle, Katherine J Lee, Na M Dang, Stephen M Graham
  Acta Paediatr. 2015 Feb
• A prospective evaluation of the symptom-based screening approach to the management of children who are contacts of tuberculosis cases.
  Rina Triasih, Colin F Robertson, Trevor Duke, Stephen M Graham
  Clin Infect Dis. 2015 Jan; 60(1):12-18

2014 (8)

• Editorial commentary: molecular diagnosis of child pneumonia: high yield, uncertain specificity.
  Stephen M Graham
  Clin Infect Dis. 2014 Sep; 59(5):686-687
• Reducing deaths from severe pneumonia in children in Malawi by improving delivery of pneumonia case management.
  Penelope M Enarson, Robert P Gie, Charles C Mwansambo, Ellubey R Maganga, Carl J Lombard, Donald A Enarson, Stephen M Graham
  PLoS One. 2014 Jul; 9(7):e102955
• The trend of tuberculosis cases in Fiji's largest treatment centre over 60 years:1950-2010
  Tamani T, Bissell K, Taylor-Smith K, Grounder S, Nguyen L, Graham SM
  Public Health Action. 2014 Jul; 4:24-26
• Chest radiography for diagnosis of tuberculosis in children: a problem of interpretation.
  Stephen M Graham
  Int J Tuberc Lung Dis. 2014 Jul; 18(7):757
• Guidance for National Tuberculosis Programmes on the management of tuberculosis in children - Second Edition
  Steve Graham (lead author)
  Stop TB Partnership Childhood TB Subgroup, World Health Organization. 2014 Jul
• Child TB Training Toolkit.
  Graham SM (lead author)
  World Health Organization. 2014 Jul
• Importance of tuberculosis control to address child survival.
  Stephen M Graham, Charalambos Sismanidis, Heather J Menzies, Ben J Marais, Anne K Detjen, Robert E Black
  Lancet. 2014 May; 383(9928):1605-1607
• A prospective study of the prevalence of tuberculosis and bacteraemia in Bangladeshi children with severe malnutrition and pneumonia including an evaluation of Xpert MTB/RIF assay.
  Mohammod Jobayer Chisti, Stephen M Graham, Trevor Duke, Tahmeed Ahmed, Hasan Ashraf, Abu Syed Golam Faruque, Sophie La Vincente, Sayera Banu, Rubhana Raqib, Mohammed Abdus Salam
  PLoS One. 2014 Apr; 9(4):e93776

2013 (2)

• Roadmap for childhood tuberculosis: towards zero deaths.
  Graham SM (lead author)
  World Health Organization. 2013 Jul
• Requirements for the clinical evaluation of new anti-tuberculosis agents in children.
  P R Donald, A Ahmed, W J Burman, M F Cotton, S M Graham, C Mendel, H McIlleron, W R Mac Kenzie, S Nachman, H S Schaaf, J R Starke, C Wingfield, A C Hesseling
  Int J Tuberc Lung Dis. 2013 Jun; 17(6):794-799

2012 (6)

• Preventive therapy in children exposed to Mycobacterium tuberculosis: problems and solutions.
  Merrin E Rutherford, Philip C Hill, Rina Triasih, Rebecca Sinfield, Reinout van Crevel, Stephen M Graham
  Trop Med Int Health. 2012 Oct; 17(10):1264-1273
• Long-term follow-up of contacts exposed to multidrug-resistant tuberculosis in Victoria, Australia, 1995-2010.
  J T Denholm, D E Leslie, G A Jenkin, J Darby, P D R Johnson, S M Graham, G V Brown, A Sievers, M Globan, L K Brown, E S McBryde
  Int J Tuberc Lung Dis. 2012 Oct; 16(10):1320-1325
• A systematic review of the burden of neonatal morbidity and mortality in the ASEAN region.
  Tran HT, Doyle LW, Lee KJ, Graham SM
  WHO SE Asian Journal of Public Health. 2012 Jul; 1:239-48
• Scaling up interventions to achieve global tuberculosis control: progress and new developments.
  Mario Raviglione, Ben Marais, Katherine Floyd, Knut Lonnroth, Haileyesus Getahun, Giovanni B Migliori, Anthony D Harries, Paul Nunn, Christian Lienhardt, Steve Graham, Jeremiah Chakaya, Karin Weyer, Stewart Cole, Stefan H E Kaufmann, Alimuddin Zumla
  Lancet. 2012 May; 379(9829):1902-1913
• Evaluation of tuberculosis diagnostics in children: 1. Proposed clinical case definitions for classification of intrathoracic tuberculosis disease. Consensus from an expert panel.
  Stephen M Graham, Tahmeed Ahmed, Farhana Amanullah, Renee Browning, Vicky Cardenas, Martina Casenghi, Luis E Cuevas, Marianne Gale, Robert P Gie, Malgosia Grzemska, Ed Handelsman, Mark Hatherill, Anneke C Hesseling, Patrick Jean-Philippe, Beate Kampmann, Sushil Kumar Kabra, Christian Lienhardt, Jennifer Lighter-Fisher, Shabir Madhi, Mamodikoe Makhene, Ben J Marais, David F McNeeley, Heather Menzies, Charles Mitchell, Surbhi Modi, Lynne Mofenson, Philippa Musoke, Sharon Nachman, Clydette Powell, Mona Rigaud, Vanessa Rouzier, Jeffrey R Starke, Soumya Swaminathan, Claire Wingfield
  J Infect Dis. 2012 May; 205 Suppl 2:S199-S208
• Evaluation of tuberculosis diagnostics in children: 2. Methodological issues for conducting and reporting research evaluations of tuberculosis diagnostics for intrathoracic tuberculosis in children. Consensus from an expert panel.
  Luis E Cuevas, Renee Browning, Patrick Bossuyt, Martina Casenghi, Mark F Cotton, Andrea T Cruz, Lori E Dodd, Francis Drobniewski, Marianne Gale, Stephen M Graham, Malgosia Grzemska, Norbert Heinrich, Anneke C Hesseling, Robin Huebner, Patrick Jean-Philippe, Sushil Kumar Kabra, Beate Kampmann, Deborah Lewinsohn, Meijuan Li, Christian Lienhardt, Anna M Mandalakas, Ben J Marais, Heather J Menzies, Grace Montepiedra, Charles Mwansambo, Richard Oberhelman, Paul Palumbo, Estelle Russek-Cohen, David E Shapiro, Betsy Smith, Giselle Soto-Castellares, Jeffrey R Starke, Soumya Swaminathan, Claire Wingfield, Carol Worrell
  J Infect Dis. 2012 May; 205 Suppl 2:S209-S215

2011 (1)

• Contact investigation of children exposed to tuberculosis in South East Asia: a systematic review.
  Rina Triasih, Merrin Rutherford, Trisasi Lestari, Adi Utarini, Colin F Robertson, Stephen M Graham
  J Trop Med. 2011 Nov; 2012:301808

News Articles (12)

2017 (1)

• Funding for new PNG TB project

2016 (4)

• MDR-TB and malaria focus of $2 million research grant
• HMHB attracts Principal Supporter
• Launch of Australian TB Caucus
• Boost for PNG TB project

2015 (7)

• 2015 in Review: January - June
• 2015 in Review: July - December
• TB award for Professor Steve Graham
• TB Conference to lead the fight
• Burnet steps up fight against TB
• Burnet role in TB Forum
• TB specialist Professor Steve Graham joins Burnet