Background

Dr Gugasyan obtained his PhD from the Walter & Eliza Hall Institute (Melbourne) and furthered his training at the Washington University School of Medicine, St.Louis, MO, (USA).

He is internationally and nationally recognised for his research on lymphocytes and the signalling circuitry within these cells that help to prevent chronic diseases such as autoimmunity and cancer.

His research team is currently focused on developing new diagnostic markers for diseases such as autoimmunity and cancer.

Appointments

• 2009-present: Senior Lecturer, Department of Immunology, Monash University, Victoria, Australia

Positions

• The Walter and Eliza Hall Institute, Victoria, Australia

Qualifications

• BSc (Hons), Monash University
• PhD, University of Melbourne

Projects (1)

Publications (13)

2020 (1)

• Distinct Immune Responses Elicited From Cervicovaginal Epithelial Cells by Lactic Acid and Short Chain Fatty Acids Associated With Optimal and Non-optimal Vaginal Microbiota.
  Delgado-Diaz DJ, Tyssen D, Hayward JA, Gugasyan R, Hearps AC, Tachedjian G
  Front Cell Infect Microbiol. 2020 Jan; 9:446

2018 (1)

• Loss of NF-kappaB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.
  O'Reilly LA, Putoczki TL, Mielke LA, Low JT, Lin A, Preaudet A, Herold MJ, Yaprianto K, Tai L, Kueh A, Pacini G, Ferrero RL, Gugasyan R, Hu Y, Christie M, Wilcox S, Grumont R, Griffin MDW, O'Connor L, Smyth GK, Ernst M, Waring P, Gerondakis S, Strasser A
  Immunity. 2018 Mar; 48(3):570-583

2017 (1)

• Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition.
  Hearps AC, Tyssen D, Srbinovski D, Bayigga L, Diaz DJD, Aldunate M, Cone RA, Gugasyan R, Anderson DJ, Tachedjian G
  Mucosal Immunol. 2017 Apr; 10(6):1480-1490

2016 (4)

• The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.
  Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J
  Sci Transl Med. 2016 May; 8(339):339ra69
• The NF-kappaB transcription factor RelA is required for the tolerogenic function of Foxp3 regulatory T cells.
  Messina N, Fulford T, O'Reilly L, Loh WX, Motyer JM, Ellis D, McLean C, Naeem H, Lin A, Gugasyan R, Slattery RM, Grumont RJ, Gerondakis S
  J Autoimmun. 2016 Apr; 70:52-62
• NFkappaB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.
  de Valle E, Grigoriadis G, O'Reilly LA, Willis SN, Maxwell MJ, Corcoran LM, Tsantikos E, Cornish JK, Fairfax KA, Vasanthakumar A, Febbraio MA, Hibbs ML, Pellegrini M, Banerjee A, Hodgkin PD, Kallies A, Mackay F, Strasser A, Gerondakis S, Gugasyan R
  J Exp Med. 2016 Mar; 213(4):421-461
• Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.
  Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NY, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M, Johnstone RW, Munoz L, Wei A, Ekert PG, Vaux DL, Wong WW, Silke J
  Cancer Cell. 2016 Feb; 29(2):145-158

2015 (1)

• Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis.
  Aldunate M, Srbinovski D, Hearps AC, Latham CF, Ramsland PA, Gugasyan R, Cone RA, Tachedjian G
  Front Physiol. 2015 Jun; 6:164

2012 (2)

• NF-kappaB subunit specificity in hemopoiesis.
  Gerondakis S, Banerjee A, Grigoriadis G, Vasanthakumar A, Gugasyan R, Sidwell T, Grumont RJ
  Immunol Rev. 2012 Mar; 246(1):272-285
• The NF-kappaB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties.
  Gugasyan R, Horat E, Kinkel SA, Ross F, Grigoriadis G, Gray D, O'Keeffe M, Berzins SP, Belz GT, Grumont RJ, Banerjee A, Strasser A, Godfrey DI, Tsichlis PN, Gerondakis S
  EMBO J. 2012 Feb; 31(3):692-706

2011 (1)

• Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-kappaB pathway.
  Stankovic S, Gugasyan R, Kyparissoudis K, Grumont R, Banerjee A, Tsichlis P, Gerondakis S, Godfrey DI
  Immunol Cell Biol. 2011 Feb; 89(2):294-303

2005 (1)

• Distinct roles for the NF-kappaB1 and c-Rel transcription factors in the differentiation and survival of plasmacytoid and conventional dendritic cells activated by TLR-9 signals.
  Meredith O'Keeffe, Raelene J Grumont, Hubertus Hochrein, Martina Fuchsberger, Raffi Gugasyan, David Vremec, Ken Shortman, Steve Gerondakis
  Blood. 2005 Nov; 106(10):3457-3464

2001 (1)

• c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription.
  R Grumont, H Hochrein, M O'Keeffe, R Gugasyan, C White, I Caminschi, W Cook, S Gerondakis
  J Exp Med. 2001 Oct; 194(8):1021-1032

News Articles (7)

2021 (1)

• Scientific discovery centre stage in Medical Research Week 2021

2019 (1)

• Student Night attracts keen interest

2017 (2)

• Strong interest in Student Night
• Protection for women at high risk of HIV

2016 (1)

• New insights into autoimmunity

2015 (1)

• Cancer Appeal needs your support

2012 (1)

• Research could help development of more effective vaccines