Background

Professor Brendan Crabb AC PhD FAA FAHMS FASM is an infectious disease researcher with a special interest in malaria. His research group develops and exploits genetic approaches to better understand malaria parasite biology, principally to help prioritise vaccine and drug targets.

Although a molecular scientist by training, Professor Crabb’s interests include addressing technical and non-technical barriers to maternal, newborn and child health in the developing world. In recent years, under the banner of Healthy Mothers Healthy Babies, he helped establish a major research field site in East New Britain in Papua New Guinea, principally to identify the underlying drivers (including malaria) of low birth weight and stunting in relatively calorie-rich, yet resource-poor settings.

Since 2008 he has been the Director and CEO of the Macfarlane Burnet Institute for Medical Research and Public Health (Burnet Institute), a research institute that has a focus on infectious diseases and maternal and child health, especially for populations most in need. Burnet has played a major role in the COVID-19 pandemic, including advising governments and advocating strongly for public health action.

Professor Crabb is President of both the Australian Global Health Alliance and the Pacific Friends of Global Health, bodies that advocate for better health equity. He is the past-President of the Association of Australian Medical Research Institutes (AAMRI), the peak body for independent medical research Institutes in Australia. Professor Crabb has played critical roles in transformative government policy and funding initiatives, including in the generation of the $20b Medical Research Future Fund.

He is currently a Fellow of the Australian Academy of Science (FAA), a Fellow of the Australian Academy of Health and Medical Sciences (FAHMS) and of the Australian Society for Microbiology (FASM). He served on the governing Council of the National Health and Medical Research Council (NHMRC) of Australia from 2016 - 2021. Internationally, he currently serves on the International Advisory Boards of the Sanger Institute (UK) and on the WHO Malaria Vaccine Advisory Committee (MALVAC) in Geneva. Professor Crabb was the Co-Founder of the 1st Malaria World Congress and of the Molecular Approaches to Malaria Conferences. In his home state of Victoria, is President of the Victorian Chapter of AAMRI.

Prior to 2008, Professor Crabb was a Senior Principal Research Fellow in the NHMRC and an International Fellow of the Howard Hughes Medical Institute in the US. He is an experienced educator having been a full-time teaching and research academic at the University of Melbourne (1996-2000) and has been immersed in education at secondary and tertiary levels ever since.

In 2015, he was awarded a Companion of the Order of Australia, Australia’s highest civilian honour, in 2019 he received the GSK Award for Research Excellence and in 2020 he was awarded the Global Citizen Prize: Australia’s Hero Award.

Listen to Professor Crabb on Episode 1 of our How Science Matters podcast

Appointments

• Director and Chief Executive Officer, Burnet Institute, 2008-ongoing
• Board Member, Telethon Kids Institute, from 2022
• Member, Medical Journal of Australia’s Editorial Advisory Committee, from 2021
• Member, mRNAVictoria Scientific Advisory Group, from 2021
• Member, Victorian Aboriginal Research Accord Reference Group, from 2021
• Member, SPARK/SPECTRUM Expert Reference Group, from 2021
• Member, Australian Academy of Health and Medical Sciences COVID-19 Expert Committee, from 2020
• Chair, Pacific Friends of Global Health, from 2020
• Board member, Institute for Health Transformation, from 2020
• Member, Victorian Government Medical Research Strategic Advisory Committee, from 2019
• Foundation Committee Member, Global Health Alliance Melbourne, from 2019
• Member, WHO Malaria Vaccine Advisory Committee (MALVAC), from 2018
• Member, Scientific Advisory Board, Wellcome Trust Sanger Institute, UK, from 2016
• Inaugural Fellow, Australian Academy of Health and Medical Sciences (FAHMS), from 2014
• Chair, Victorian Chapter, Association of Australian Medical Research Institutes, from 2014
• Club Melbourne Ambassador, from 2014
• Member, Alfred Medical Research & Education Precinct Council (Chair 2013-16), from 2013
• Director, Board of AMREP Animal Services Pty Ltd, Victoria, from 2010
• Adjunct Professor, Monash University, from 2010
• Adjunct Professor, The University of Melbourne, from 2008
• Member, Board of the Gene Technology Access Centre (GTAC), Victoria, from 2001

Qualifications

• 1992: PhD, (Virology) School of Veterinary Science, University of Melbourne,Victoria, Australia
• 1988: BSc, (Hons) Department of Microbiology, University of Melbourne, Australia
• 1987: BSc, University of Melbourne, Australia
• 2016: Advanced Management Program (4 weeks), Columbia University, USA

Projects (3)

Current (2)

• 

  Healthy Mothers, Healthy Babies

• 

  Host red blood cell modification sustains the virulence of malaria parasites

Publications (64)

2023 (1)

• Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines.
  Drew DR, Wilson DW, Weiss GE, Yeoh LM, G Henshall I, Crabb BS, Dutta S, Gilson PR, Beeson JG
  Cell Mol Life Sci. 2023 Feb; 80(3):74

2022 (5)

• PfATP4 inhibitors in the Medicines for Malaria Venture Malaria Box and Pathogen Box block the schizont-to-ring transition by inhibiting egress rather than invasion.
  Barnes CBG, Dans MG, Jonsdottir TK, Crabb BS, Gilson PR
  Front Cell Infect Microbiol. 2022 Nov; 12:1060202
• The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites.
  Looker O, Dans MG, Bullen HE, Sleebs BE, Crabb BS, Gilson PR
  Traffic. 2022 Sep; 23(9):442-461
• The impact of three progressively introduced interventions on second wave daily COVID-19 case numbers in Melbourne, Australia.
  Saul A, Scott N, Spelman T, Crabb BS, Hellard M
  BMC Infect Dis. 2022 Jun; 22(1):514
• The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture.
  Bullen HE, Sanders PR, Dans MG, Jonsdottir TK, Riglar DT, Looker O, Palmer CS, Kouskousis B, Charnaud SC, Triglia T, Gabriela M, Schneider MP, Chan JA, de Koning-Ward TF, Baum J, Kazura JW, Beeson JG, Cowman AF, Gilson PR, Crabb BS
  Mol Microbiol. 2022 Apr; 117(5):1245-1262
• A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell.
  Gabriela M, Matthews KM, Boshoven C, Kouskousis B, Jonsdottir TK, Bullen HE, Modak J, Steer DL, Sleebs BE, Crabb BS, Koning-Ward TF, Gilson PR
  PLoS Pathog. 2022 Feb; 18(2):e1009977

2021 (8)

• Shot of Hope - Australia’s role in vaccinating the world against COVID-19. (PUBLIC HEALTH REPORT)
  End COVID for All Expert Advisory Group (including Burnet Institute's Brendan Crabb and Michael Toole)
  End COVID for All. 2021 Oct
• Protecting children from COVID-19 andmaking schools and childcare safer. (PUBLIC HEALTH REPORT)
  OZSAGE Working Group (inlcuding co-author Brendan Crabb)
  OzSage. 2021 Oct
• Tougher restrictions in NSW's 12 'LGAs of Concern' turns the corner on cases, not just rising vaccination levels. (PUBLIC HEALTH REPORT)
  Saul A, Crabb B, Stoové M
  Know-C19. 2021 Sep; September:1-6
• The introduction of a mandatory mask policy was associated with significantly reduced COVID-19 cases in a major metropolitan city.
  Scott N, Saul A, Spelman T, Stoove M, Pedrana A, Saeri A, Grundy E, Smith L, Toole M, McIntyre CR, Crabb BS, Hellard M
  PLoS One. 2021 Jul; 16(7):e0253510
• Defining the Essential Exportome of the Malaria Parasite.
  Jonsdottir TK, Gabriela M, Crabb BS, F de Koning-Ward T, Gilson PR
  Trends Parasitol. 2021 May; 37(7):664-675
• Characterisation of complexes formed by parasite proteins exported into the host cell compartment of Plasmodium falciparum infected red blood cells.
  Jonsdottir TK, Counihan NA, Modak JK, Kouskousis B, Sanders PR, Gabriela M, Bullen HE, Crabb BS, de Koning-Ward TF, Gilson PR
  Cell Microbiol. 2021 Mar; 23(8):e13332
• Mycoplasma genitalium and Other Reproductive Tract Infections in Pregnant Women, Papua New Guinea, 2015-2017.
  Scoullar MJL, Boeuf P, Peach E, Fidelis R, Tokmun K, Melepia P, Elijah A, Bradshaw CS, Fehler G, Siba PM, Erskine S, Mokany E, Kennedy E, Umbers AJ, Luchters S, Robinson LJ, Wong NC, Vallely AJ, Badman SG, Vallely LM, Fowkes FJI, Morgan C, Pomat W, Crabb BS, Beeson JG
  Emerg Infect Dis. 2021 Mar; 27(3):894-904
• Risk factors and knowledge associated with high unintended pregnancy rates and low family planning use among pregnant women in Papua New Guinea.
  Peach E, Morgan C, Scoullar MJL, Fowkes FJI, Kennedy E, Melepia P, Homiehombo P, Au L, Luchters S, Umbers AJ, Vallely A, Vallely LM, Kelly-Hanku A, Robinson LJ, Crabb BS, Elijah A, Siba PM, Pomat W, Beeson JG
  Sci Rep. 2021 Jan; 11(1):1222

2020 (7)

• Building momentum for malaria vaccine research and development: key considerations.
  Chitnis CE, Schellenberg D, Vekemans J, Asturias EJ, Bejon P, Collins KA, Crabb BS, Herrera S, Laufer M, Rabinovich NR, Roestenberg M, Shearley A, Tinto H, Wentworth M, O'Brien K, Alonso P
  Malar J. 2020 Nov; 19(1):421
• Impact of Victoria's Stage 3 lockdown on COVID-19 case numbers
  Saul A, Scott N, Crabb BS, Majumdar SS, Coghlan B, Hellard ME
  MJA. 2020 Nov; 213(11):494-496
• Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial.
  Agius PA, Cutts JC, Oo WH, Thi A, O'Flaherty K, Aung KZ, Thu HK, Aung PP, Thein MM, Zaw NN, Htay WYM, Soe AP, Razook Z, Barry AE, Htike W, Devine A, Simpson JA, Crabb BS, Beeson JG, Pasricha N, Fowkes FJI
  PLoS Med. 2020 Aug; 17(8):e1003177
• The most promising treatments for COVID-19 (Updated 6th July 2020)
  Lewin S, Copolov D, Crabb B, Cuthbertson A, Doherty P, Hoy W, Kelleher A, Majumdar S, Tachedjian G
  Rapid Res Infor Forum. 2020 May
• The most promising vaccines for COVID-19. (Updated 17.6.2020)
  Cunningham A, Chappell K, Copolov D, Crabb B, Cuthbertson A, Doherty P, Drummer H, Foley C, Godfrey D, Halton J, Kelleher A , Majumdar S, McDonald C, Munro T, Purcell D, Young P
  Rapid Res Infor Forum. 2020 May
• A strategic framework to ease community-wide Covid-19 suppression measures.
  Coghlan B, Majumdar SS, Pedrana A, Hellard ME, Crabb BS
  MJA. 2020 Apr; Epub preprint
• Screening the Medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of Plasmodium falciparum reveals several inhibitory compounds.
  Dans MG, Weiss GE, Wilson DW, Sleebs BE, Crabb BS, de Koning-Ward TF, Gilson PR
  Int J Parasitol. 2020 Mar; 50(3):235-252

2019 (4)

• A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4.
  Gilson PR, Kumarasingha R, Thompson J, Zhang X, Penington JS, Kalhor R, Bullen HE, Lehane AM, Dans MG, de Koning-Ward TF, Holien JK, Soares da Costa TP, Hulett MD, Buskes MJ, Crabb BS, Kirk K, Papenfuss AT, Cowman AF, Abbott BM
  Sci Rep. 2019 Jul; 9(1):10292
• Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies
  Alanine DGW, Quinkert D, Kumarasingha R, Mehmood S, Donnellan DR, Minkah NK, Dadonaite B, Diouf A, Galaway F, Silk SE, Jamwal A, Marshall JM, Miura K, Foquet L, Elias SC, ve M. Labbe´ G , Douglas AD, Jin J, Payne RO, Illingworth JJ, 1 David J. Pattinson DJ, Pulido D, Williams BG, de Jongh WA, Wright GJ, Kappe SHI, Robinson CV, Long CA, Crabb BS Gilson PR, Higgins MK, Draper SJ
  Cell. 2019 Jun; 178(1):216-228
• The N-terminus of EXP2 forms the membrane-associated pore of the protein exporting translocon PTEX in Plasmodium falciparum.
  Sanders PR, Dickerman BK, Charnaud SC, Ramsland PA, Crabb BS, Gilson PR
  J Biochem. 2019 Mar; 165(3):239-248
• Evaluation of 4-amino 2-anilinoquinazolines against Plasmodium and other apicomplexan parasites in vitro and in a P. falciparum humanized NOD-scid IL2Rgamma(null) mouse model of malaria.
  Gilson PR, Nguyen W, Poole WA, Teixeira JE, Thompson JK, Guo K, Stewart RJ, Ashton TD, White KL, Sanz LM, Gamo FJ, Charman SA, Wittlin S, Duffy J, Tonkin CJ, Tham WH, Crabb BS, Cooke BM, Huston CD, Cowman AF, Sleebs BE
  Antimicrob Agents Chemother. 2019 Feb; 63(3):e01804-18

2018 (4)

• Effectiveness of repellent delivered through village health volunteers on malaria incidence in villages in South-East Myanmar: a stepped-wedge cluster-randomised controlled trial protocol.
  Win Han Oo, Cutts JC, Agius PA, Kyaw Zayar Aung, Poe Poe Aung, Aung Thi, Nyi Nyi Zaw, Htin Kyaw Thu, Wai Yan Min Htay, Ataide R, O'Flaherty K, Ai Pao Yawn, Aung Paing Soe, Beeson JG, Crabb B, Pasricha N, Fowkes FJI
  BMC Infect Dis. 2018 Dec; 18(1):663
• Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export.
  Charnaud SC, Kumarasingha R, Bullen HE, Crabb BS, Gilson PR
  PLoS One. 2018 Nov; 13(11):e0204785
• Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte.
  Marapana DS, Dagley LF, Sandow JJ, Nebl T, Triglia T, Pasternak M, Dickerman BK, Crabb BS, Gilson PR, Webb AI, Boddey JA, Cowman AF
  Nat Microbiol. 2018 Aug; 3(9):1010-1022
• Spatial organisation of protein export in malaria parasite blood stages.
  Charnaud SC, Jonsdottir TK, Sanders PR, Bullen HE, Dickerman BK, Kouskousis B, Palmer CS, Pietrzak HM, Laumaea AE, Erazo AB, McHugh E, Tilley L, Crabb BS, Gilson PR
  Traffic. 2018 Apr; 19(8):605-623

2017 (6)

• Development of a novel CD4+ TCR transgenic line that reveals a dominant role for CD8+ dendritic cells and CD40 signaling in the generation of helper and CTL responses to blood-stage malaria.
  Fernandez-Ruiz D, Lau LS, Ghazanfari N, Jones CM, Ng WY, Davey GM, Berthold D, Holz L, Kato Y, Enders MH, Bayarsaikhan G, Hendriks SH, Lansink LIM, Engel JA, Soon MSF, James KR, Cozijnsen A, Mollard V, Uboldi AD, Tonkin CJ, de Koning-Ward TF, Gilson PR, Kaisho T, Haque A, Crabb BS, Carbone FR, McFadden GI, Heath WR
  J Immunol. 2017 Oct; Epub ahead of print
• The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites.
  Charnaud SC, Dixon MWA, Nie CQ, Chappell L, Sanders PR, Nebl T, Hanssen E, Berriman M, Chan JA, Blanch AJ, Beeson JG, Rayner JC, Przyborski JM, Tilley L, Crabb BS, Gilson PR
  PLoS One. 2017 Jul; 12(7):e0181656
• Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.
  McCallum FJ, Persson KM, Fowkes FJ, Reiling L, Mugyenyi CK, Richards JS, Simpson JA, Williams TN, Gilson PR, Hodder AN, Sanders PR, Anders RF, Narum DL, Chitnis C, Crabb BS, Marsh K, Beeson JG.
  J Leukoc Biol. 2017 Apr; 101(4):913-925
• Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate.
  Counihan N, Chisholm SA, Bullen HE, Srivastava A, Sanders PR, Jonsdottir TK, Weiss GE, Ghosh S, Crabb BS, Creek DJ, Gilson PR, de Koning-Ward TF
  eLife. 2017 Mar; 6(pii):e23217
• Host cell remodeling in malaria parasites: a new pool of potential drug targets.
  Gilson PR, Chisholm SA, Crabb BS, de Koning-Ward TF
  Int J Parasitol. 2017 Feb; 47(2-3):119-127
• Optimization of 2-anilino 4-amino substituted quinazolines into potent antimalarial agents with oral in vivo activity.
  Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Sabroux H, Crabb BS, Avery VM, Cowman AF, Sleebs BE
  J Med Chem. 2017 Jan; 60(3):1171-1188

2016 (12)

• Disrupting the allosteric interaction between the Plasmodium falciparum cAMP-dependent kinase and its regulatory subunit.
  Littler DR, Bullen HE, Harvey KL, Beddoe T, Crabb BS, Rossjohn J, Gilson PR
  J Biol Chem. 2016 Dec; 291(49):25375-25386
• Molecular genetic approaches to malaria research. (Book Chapter)
  Elsworth B, Azevedo MF, Crabb BS, Gilson PR
  in Advances in Malaria Research (Eds. Gaur D, Chitnis CE and Chauhan VS) Wiley Blackwell. 2016 Dec
• Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum.
  Dickerman BK, Elsworth B, Cobbold SA, Nie CQ, McConville MJ, Crabb BS, Gilson PR
  Sci Rep. 2016 Nov; 6:37502
• Trafficking of the exported P. falciparum chaperone PfHsp70x.
  Rhiel M, Bittl V, Tribensky A, Charnaud SC, Strecker M, Müller S, Lanzer M, Sanchez C, Schaeffer-Reiss C, Westermann B, Crabb BS, Gilson PR, Külzer S, Przyborski JM
  Sci Rep. 2016 Nov; 6:36174
• Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.
  Fernandez-Ruiz D, Ng WY, Holz LE, Ma JZ, Zaid A, Wong YC, Lau LS, Mollard V, Cozijnsen A, Collins N, Li J, Davey GM, Kato Y, Devi S, Skandari R, Pauley M, Manton JH, Godfrey DI, Braun A, Tay SS, Tan PS, Bowen DG, Koch-Nolte F, Rissiek B, Carbone FR, Crabb BS, Lahoud M, Cockburn IA, Mueller SN, Bertolino P, McFadden GI, Caminschi I, Heath WR
  Immunity. 2016 Oct; 45(4):889-902
• Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites.
  Prinz B, Harvey KL, Wilcke L, Ruch U, Engelberg K, Biller L, Lucet I, Erkelenz S, Heincke D, Spielmann T, Doerig C, Kunick C, Crabb BS, Gilson PR, Gilberger TW
  Sci Rep. 2016 Oct; 6:34479
• Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation.
  Buskes MJ, Harvey KL, Richards BJ, Kalhor R, Christoff RM, Gardhi CK, Littler DR, Cope ED, Prinz B, Weiss GE, O'Brien NJ, Crabb BS, Deady LW, Gilson PR, Abbott BM
  Org Biomol Chem. 2016 Apr; 14(20):4617-4639
• Exploration of 3-methylisoquinoline-4-carbonitriles as protein kinase A inhibitors of Plasmodium falciparum.
  Buskes MJ, Harvey KL, Prinz B, Crabb BS, Gilson PR, Wilson DJ, Abbott BM
  Bioorg Med Chem. 2016 Mar; 24(11):2389-2396
• Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150.
  Elsworth B, Sanders PR, Nebl T, Batinovic S, Kalanon M, Nie CQ, Charnaud SC, Bullen HE, de Koning Ward TF, Tilley L, Crabb BS, Gilson PR
  Cell Microbiol. 2016 Mar; 18(11):1551-1569
• Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection.
  Kennedy AT, Schmidt CQ, Thompson JK, Weiss GE, Taechalertpaisarn T, Gilson PR, Barlow PN, Crabb BS, Cowman AF, Tham WH
  J Immunol. 2016 Feb; 196(3):1239-1248
• Overlaying Molecular and Temporal Aspects of Malaria Parasite Invasion.
  Weiss GE, Crabb BS, Gilson PR
  Trends Parasitol. 2016 Jan; 32(4):284-295
• Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort.
  Dent AE, Malhotra I, Wang X, Babineau D, Yeo KT, Anderson T, Kimmel RJ, Angov E, Lanar DE, Narum D, Dutta S, Richards J, Beeson JG, Crabb BS, Cowman AF, Horii T, Muchiri E, Mungai PL, King CL, Kazura JW
  Clin Vaccine Immunol. 2016 Jan; 23(2):104-116

2015 (6)

• Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.
  Wilson DW, Goodman CD, Sleebs BE, Weiss GE, de Jong NW, Angrisano F, Langer C, Baum J, Crabb BS, Gilson PR, McFadden GI, Beeson JG
  BMC Biol. 2015 Jul; 13(1):52
• A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression.
  Josling GA, Petter M, Oehring SC, Gupta AP, Dietz O, Wilson DW, Schubert T, Längst G, Gilson PR, Crabb BS, Moes S, Jenoe P, Lim SW, Brown GV, Bozdech Z, Voss TS, Duffy MF
  Cell Host Microbe. 2015 Jun; 17(6):741-751
• Advances in molecular genetic systems in malaria.
  de Koning-Ward TF, Gilson PR, Crabb BS
  Nat Rev Microbiol. 2015 May; 13(6):373-387
• Research as altruism.
  Swannell C, Crabb B
  MJA. 2015 Apr; 202(4):63-64
• Why Australia needs a Medical Research Future Fund.
  Cunningham AL, Anderson T, Bennett CC, Crabb BS, Goodier G, Hilton D, Koff E, Trapani J
  Med J Aust. 2015 Feb; 202(3):123-124
• Identification of Potent Phosphodiesterase Inhibitors that Demonstrate Cyclic Nucleotide-Dependent Functions in Apicomplexan Parasites.
  Howard BL, Harvey KL, Stewart R, Azevedo MF, Crabb BS, Jennings IG, Sanders PR, Manallack DT, Thompson PE, Tonkin CJ, Gilson PR
  ACS Chem Biol. 2015 Jan; 10(4):1145-1154

2014 (7)

• Plasmodium falciparum Transfected with Ultra Bright NanoLuc Luciferase Offers High Sensitivity Detection for the Screening of Growth and Cellular Trafficking Inhibitors.
  Azevedo MF, Nie CQ, Elsworth B, Charnaud SC, Sanders PR, Crabb BS, Gilson PR
  PLoS One. 2014 Nov; 9(11):e112571
• Insights and controversies into the role of the key Apicomplexan invasion ligand, Apical Membrane Antigen 1.
  Harvey KL, Yap A, Gilson PR, Cowman AF, Crabb BS
  Int J Parasitol. 2014 Aug; 44(12):853-857
• PTEX is an essential nexus for protein export in malaria parasites.
  Elsworth B, Matthews K, Nie CQ, Kalanon M, Charnaud SC, Sanders PR, Chisholm SA, Counihan NA, Shaw PJ, Pino P, Chan J-A, Azevedo MF, Rogerson SJ, Beeson JG, Crabb BS, Gilson PR, de Koning-Ward TF
  Nature. 2014 Jul; 511(7511):587-591
• CD8+ T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria.
  Lau LS, Fernandez-Ruiz D, Mollard V, Sturm A, Neller MA, Cozijnsen A, Gregory JL, Davey GM, Jones CM, Lin YH, Haque A, Engwerda CR, Nie CQ, Hansen DS, Murphy KM, Papenfuss AT, Miles JJ, Burrows SR, de Koning-Ward T, McFadden GI, Carbone FR, Crabb BS, Heath WR
  PLoS Pathog. 2014 May; 10(5):e1004135
• The role of parasite Heat Shock Proteins in protein trafficking and host cell remodeling. (Book Chapter)
  Charnaud SC, Crabb BS, Gilson PR
  in Heat Shock Proteins of Malaria (Eds Addmore Shonhai, Gregory L. Blatch). 2014 Mar; Chapter 6:99-118
• Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites.
  Yap A, Azevedo MF, Gilson PR, Weiss GE, O Neill MT, Wilson DW, Crabb BS, Cowman AF
  Cell Microbiol. 2014 Feb; 16(5):642-656
• Protein export in malaria parasites: an update.
  Elsworth B, Crabb BS, Gilson PR
  Cell Microbiol. 2014 Jan; 16(3):355-363

2013 (4)

• The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth.
  Matthews K, Kalanon M, Chisholm SA, Sturm A, Goodman CD, Dixon MW, Sanders PR, Nebl T, Fraser F, Haase S, McFadden GI, Gilson PR, Crabb BS, de Koning-Ward TF
  Mol Microbiol. 2013 Jul; 89(6):1167-1186
• Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.
  Richards JS, Arumugam TU, Reiling L, Healer J, Hodder AN, Fowkes FJ, Cross N, Langer C, Takeo S, Uboldi AD, Thompson JK, Gilson PR, Coppel RL, Siba PM, King CL, Torii M, Chitnis CE, Narum DL, Mueller I, Crabb BS, Cowman AF, Tsuboi T, Beeson JG
  J Immunol. 2013 Jun; 191(2):795-809
• Inhibition of Plasmodium falciparum CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development.
  Azevedo MF, Sanders PR, Krejany E, Nie CQ, Fu P, Bach LA, Wunderlich G, Crabb BS, Gilson PR
  Biochem J. 2013 Apr; 452(3):433-441
• Host cell remodelling and protein trafficking.
  Haase S, Bullen HE, Charnaud SC, Crabb BS, Gilson PR, de Koning-Ward TF
  in Malaria Parasites: Comparative Genomics , Evolution and Molecular Biology Ed. Carlton JM, Perkins SL, Deitsch KW. 2013 Jan; pp:199-219

News Articles (352)

2023 (8)

• COVID derailed tuberculosis progress and urgent action is needed
• Three years into the pandemic, it’s clear COVID won’t fix itself. Here’s what we need to focus on next
• Two-pronged approach to target critical malaria protein
• Burnet welcomes announcement of regional health investment package
• Australia’s long COVID problem needs to be acknowledged
• International podcast award for How Science Matters
• Health leaders support call for COVID strategy rethink
• COVID exploits our year of living dangerously

2022 (37)

• 2022 in Review: July to December
• 2022 in Review: January to June
• New report: Progress in reducing malaria burden has stalled
• Focus on prevention in Burnet Long COVID submission
• Professor Brendan Crabb admitted to the Australian Academy of Science
• How Science Matters nominated for Australian Podcast Award
• Associate Professor David Anderson stepping down
• COVID isolation rule change 'disappointing'
• Isolation: A key pillar of COVID control
• Elimination of hepatitis C the focus of new funding grant
• Imagining COVID is ‘like the flu’ is cutting thousands of lives short. It’s time to wake up.
• Preparing for the next pandemic
• Risk of long COVID builds each time you get infected
• A breakthrough - three million free N95 and KN95 masks for Victorians
• Burnet launches bold 2030 Strategy
• Reducing COVID-19 transmission top priority
• Call for new mindset on COVID-19
• A vaccines-plus strategy: our defence against COVID-19
• Don’t pump brakes: our COVID strategy must change to reflect reality
• Vale Professor Ruth Bishop AC
• Excelling in a year of challenges and pandemic
• Burnet Institute partners with Moderna to develop novel mRNA vaccines
• Burnet support for investment boost in region's health
• Burnet Institute and WEHI stand with transgender and gender diverse people
• Professor Elizabeth Hartland new Chair of VicAAMRI
• Budget funding for medical research welcomed
• Concern over slow third-dose take up
• As tuberculosis resurges in the Asia Pacific, what lessons from Covid can save Australia?
• Combatting global vaccine inequity
• New malaria treatments essential as drug resistance grows
• Adapting to a ‘pandemic enlightenment phase’
• OzSage urging rethink on COVID commentary
• Australia must go to 'next level' on vaccine support
• Australia urged to boost support for Covax
• Vaccine equity a priority for Australia
• What it might mean to be COVID-normal
• Backed By Science: Here’s How We Can Eliminate COVID-19

2021 (67)

• 2021 in Review: July to December
• 2021 in Review: January to June
• A national response to COVID-19 is long overdue, but is yet to happen
• ‘Can’t have business as usual’ with Omicron curveball‘
• Step forward for AIID
• Philanthropy Award for Miller Foundation
• Call for action on global COVID-19 vaccines
• Vaccine equity a 'must' for new variant
• While children wait for their COVID jab, caution is still required
• Professor Caroline Homer appointed NHMRC Council Chair
• COVID doesn’t need to run rampant. Here are six ways to keep cases low in the next year
• PNG is back on the brink of a delta variant disaster
• Podcast: Modelling COVID-19 - How Science Matters
• PNG calls for international help amid Delta surge
• Pandemic levels of abuse directed at COVID-19 experts
• Time for Australia to get serious about global vaccine equity
• Vaccinate the world before virus mutates
• OzSage advice on protecting children from COVID-19
• Vaccines-plus crucial to COVID-19 exit
• A regional COVID-19 response needs more from Australia
• Burnet Support of Congress Vaccination strategy
• New Burnet modelling: Tougher restrictions in NSW's 12 LGAs of Concern 'turns the corner' on cases, not just rising vaccination levels
• Podcast Ep. 8: Lost voice – COVID's impact on malaria
• Report reveals COVID's impact on HIV, TB and Malaria programs
• Victoria's community effort helps avert around 6000 COVID-19 cases, Burnet modelling shows
• Podcast Ep. 6: Motherhood in a time of pandemic
• Ventilation a failing and an opportunity
• Podcast Ep. 5: Is COVID-normal possible?
• Podcast Ep. 4: Everyone’s an epidemiologist!
• Podcast Ep. 3: No one is safe until everyone is safe
• Why our COVID ambition must remain close to zero cases, even as we climb to high vaccination
• Rising COVID-19 cases in NSW “a national emergency”
• Podcast Ep. 2: Are vaccines the silver bullet?
• Podcast Ep. 1: A year like no other, the pandemic continues
• Professor Brendan Crabb ABC TV News Breakfast
• World-first study shows effectiveness of masks in preventing COVID transmission
• Burnet Institute Travel Awards
• How will variants change our response to COVID-19?
• Experts unite to help get Aussies vaccinated against COVID-19
• Tighter ‘Stage 4’ restrictions will likely be needed to control Delta variant outbreak in NSW, new modelling shows
• Morrison’s COVID roadmap a step in the right direction
• The path to exiting the pandemic is paved with vaccinations
• mRNA advisory appointment for Professor Brendan Crabb
• Lockdown alternatives to be found in unshackled thinking
• Are lockdowns the answer every time there is a COVID-19 outbreak?
• Clear leadership and purpose-built quarantine crucial to beating COVID
• Taking actions towards Reconciliation
• AAS Fellowship for Professor Brendan Crabb
• Australian Institute for Infectious Disease coming to world-leading Melbourne Biomedical Precinct
• A year of challenges and successes
• We must use caution to break out of Fortress Australia
• WHO’s counting on us to stop the next pandemic
• Protecting PNG from an escalating COVID-19 outbreak is urgent business for Australia
• Surging global cases of COVID-19 threaten Australia’s exit strategy
• Australia's vaccine rollout pivots with new advice about AstraZeneca vaccine
• Australia urged to send 1 million vaccines to PNG
• Burnet welcomes Australia's urgent COVID-19 support package for PNG
• A catastrophe looms with PNG’s COVID crisis. Australia needs to respond urgently
• COVID-19 Timeline: How Science Matters
• Hurdles remain to our COVID-19 future, but it’s on the horizon
• Your vaccine questions answered
• Burnet welcomes COVID-19 vaccine rollout
• Small holes make for big problems in pandemic Australia
• Single dose vaccine data encouraging
• New study highlights family planning needs in PNG
• Herd immunity muddies the waters
• Hang in there, Australia — we’re in great shape but we’re only halfway through the COVID marathon

2020 (47)

• 2020 in Review: July to December
• Congratulations to Professor Brendan Crabb awarded Global Citizen Prize: Australia's Hero Award
• Athena SWAN Bronze Award for Burnet Institute
• Zero-COVID attitude set Australia apart
• Global Citizen Prize to Professor Brendan Crabb
• Burnet feted for HIV leadership
• Burnet and VicAAMRI welcome medical research investment
• Blaming and shaming breaks a cardinal rule of public health
• 'You can’t make malaria wait': Hidden risks in COVID-19 foreign aid
• Australia to get new hub for infectious diseases and global health
• Celebrating NAIDOC Week
• UN appointment for Natasha Stott Despoja
• Burnet a RESULTS Leader
• Government funding for regional COVID vaccine rollout welcomed
• IMPACT special edition now online!
• Go for gold. Why Victoria should aim for zero COVID-19 mystery cases.
• Science at heart of Victoria's road to recovery
• MRFF, COVID-19 Budget commitments welcomed
• Focus on contact tracing in Victorian recovery
• Editorial outlines criteria for recovery
• Focus on milestones, not time frames for COVID exit
• Australia to commit AUD$80m for access to COVID-19 vaccine for all
• Insect repellent can advance the malaria elimination agenda
• 2019 a record year for Burnet: Annual Report released
• The crucial questions we need answered about COVID-19
• Welcoming Professor Sandra Eades to the Burnet Board
• Victorian restrictions avert thousands of new infections
• Community undersold in Australia’s response to COVID-19
• Focus on elimination, community empowerment
• Deputy Chief Medical Officer supports wearing of face masks/coverings in Melbourne when physical distancing not possible
• Burnet welcomes historic Ministerial appointment
• QB honours for Robert Milne, Suzanne Crowe
• Burnet welcomes Australia's vaccine pledge
• Burnet a knowledge hub for COVID-19
• COVID-19 modelling was 'right'
• National Reconciliation Week: In This Together
• Victoria leading the way on COVID-19 research
• Burnet researchers share in NHMRC grants
• Macquarie Group Foundation pledges AUD$1 million to Optimise Study
• Evidence-based focus the key for Australia's COVID-19 exit strategy
• COVID-19 tests under the microscope
• Trump's decision to cut WHO funding was a mistake
• The case for greater stringency on COVID-19
• COVID-19: Every day matters now
• Statement of support for Chief Medical Officer and Victorian Chief Health Officer
• $6 million boost to COVID-19 public health response
• Humanitarian Award to support HMHB

2019 (13)

• Research Excellence Award for Professor Brendan Crabb AC
• Support for plan to boost global health goals
• Life lessons for new graduates
• Burnet staff finalists at Research Australia Awards
• Videos unlock malaria mystery
• Exciting new study identifies antibodies to fight malaria
• Queen's Birthday Honours
• Burnet Travel Awards
• Burnet moves to create Reconciliation Action Plan
• Victorian budget investments welcomed
• Record-breaking year for Burnet
• Election focus on research-led healthcare
• International Women's Day

2018 (32)

• Cosmos' insights into stunting
• Exploring challenges in global health
• Major milestone for Healthy Mothers, Healthy Babies
• A Fenner Award first
• Miles to go to end HIV
• New MRFF funding priorities welcomed
• Health experts demand action on climate change
• Burnet appointments to NHMRC
• Alfred Research Alliance heralds new era
• Farewell to stellar physician, researcher and mentor at Burnet
• Trailblazer in maternal health joins Burnet
• Malaria elimination to be stepped up, and fast
• The status quo is not OK in fight against malaria
• 1st Malaria World Congress issues Statement of Action
• Commitment now the most important tool to beat malaria
• Malaria elimination features on ABC TV's The World program
• Diseases like malaria know no borders
• 1st Malaria World Congress opens
• Malaria a 'disease of poverty'
• Malaria in the media spotlight ahead of MWC2018
• Malaria Dialogues: Join the discussion
• Baby Tessie lost her mum post-childbirth
• Momentum for malaria elimination is unstoppable
• Burnet Travel Awards
• Global Health Security: Why Malaria Elimination is a Priority
• 2017 Annual Report highlights terrific year
• Medical research commitment welcomed
• Vale Professor David Cooper
• Research focus to address TB 'global crisis'
• Islands Petroleum backs HMHB
• Bill Gates calls for Australia to lead fight against malaria
• Vaccine hope as Burnet research unlocks malaria secrets

2017 (14)

• Burnet excels in NHMRC funding
• Key partnership to improve health for Papua New Guineans
• Saving Lives and SIF: Aaron’s story
• Burnet welcomes new regional Health Security Initiative
• Burnet endorses marriage equality
• Bank South Pacific support for HMHB
• Burnet welcomes overhaul of NHMRC grants program
• MRFF funding for clinical trials welcomed
• 2016 Annual Report highlights record-breaking year
• Burnet welcomes vital funding boost by Victorian Government
• Leaders lend support for HMHB
• Burnet joins new Health Alliance
• A landmark era for Burnet Institute
• Precious HMHB samples make pre-Christmas dash to Melbourne

2016 (18)

• NHMRC grants for Burnet researchers
• Role for Brendan Crabb on Victorian research panel
• Burnet launches Disease Elimination Strategy
• MoU to benefit PNG health
• Lifetime contribition award to Professor Ian Gust AO
• Research priorities welcomed
• Burnet 2020
• Call for research where it's most needed
• Australia increases contribution to Global Fund to Fight AIDS, TB and Malaria
• Brendan Crabb named a True Leader
• Medical Research plan welcomed
• 2015 Annual Report now available
• From heartbreak to hope: A personal insight from Kokopo
• Burnet, University of PNG forge new ties
• HMHB attracts Principal Supporter
• Burnet welcomes MRFF milestone
• Link between TB, poverty explored
• Burnet profiled in The Lancet

2015 (34)

• 2015 in Review: January - June
• Medical research critical to Australia’s innovation future
• MRDC supporting HMHB program
• AMREP Prize for Burnet research
• Sir Frank Macfarlane Burnet Address
• Time for the final push to eradicate polio
• What's the fuss about the MRFF?
• Director's Seminar: Professor Jim Kazura
• Governor visits Burnet
• NHMRC Award for Burnet researchers
• GuoMinXinHe Group becomes a Founding Partner of the Alastair Lucas Endowment Fund
• Alastair Lucas honoured at Tribute Service
• Burnet appointment to NHMRC Council
• Vale Alastair Field Lucas AO, Burnet Chairman
• Healthy Mothers, Healthy Babies lab officially opened in Kokopo
• Historic launch of HMHB program in Kokopo
• Strong support for PNG health
• Challenges and achievements in PNG health
• 2014 Burnet Annual Financial Report now online
• Science pledge encouraging
• Medical research a Budget winner
• This Mother's Day spare a thought for mums and their babies in PNG
• Help us fit out Kokopo lab
• World Health Day Focus - Collaborative Research
• Fellowships for Burnet excellence
• Burnet steps up fight against TB
• Burnet role in TB Forum
• Vale Rt Hon Malcolm Fraser AC
• Burnet a research exemplar
• Why Australia needs a Medical Research Future Fund
• Professor Anne Kelso AO to head NHMRC
• Fund's focus on malaria, TB
• AC honour for Burnet's Professor Brendan Crabb
• China ties strengthened

2014 (37)

• 2014 in Review: January - June
• 2014 In Review: July - December
• Burnet welcomes MRFF revised funding package
• Burnet takes HMHB to the top in PNG
• Burnet welcomes review to strengthen independent MRIs
• Professor Crabb hands over AAMRI leadership baton
• Medical Research Future Fund a potential game changer
• Burnet welcomes support to address appalling maternal mortality in PNG
• Campaign launched to ensure MRFF becomes a reality
• Burnet farewells Professor Sharon Lewin
• Medical investment by government tends to stimulate philanthropy
• Australia’s medical research sector backs the Medical Research Future Fund
• Burnet celebrates National Science Week
• Medical research a major export earner
• AIDS 2014: Ruthless honesty essential to fight AIDS
• Major breakthrough in quest for new malaria drugs
• AIDS 2014: Transmission: The Journey from AIDS to HIV
• AIDS 2014: Conversation Hour at Burnet Institute
• AIDS 2014: The Experts Talk
• Clinton, Geldof and Sidibé to present at AIDS 2014
• Tackling HIV latency: A path to a cure for HIV
• A remarkable year for the Burnet Institute
• Leading malaria researcher the 2014 Gust-McKenzie Medallist
• Researchers find the funding cure
• World's leading vaccine experts in Melbourne
• Burnet Institute welcomes Global Health Melbourne Plan
• Ill times for medical research as institutes face ballooning costs
• Burnet secures medical R&D agreement in China
• Global burden of vector-borne diseases the focus of World Health Day 2014
• Burnet launches three-year Myanmar program
• If it's broke, fix it: Moving from three to five year grants
• Burnet visits innovative research centre in Bangladesh
• Advocates push for Australia to take greater role against TB
• Chloe Bryce-Shorten joins call for health equality for women
• Professor Ian Gust AO honoured at special tribute dinner
• Victorian medical research takes centre stage at Parliament House
• Australia’s medical research institutes exceed national and global benchmarks

2013 (31)

• 2013: Year in Review
• Eliminating malaria: vaccines, treatment and prevention.
• Malaria project in NHMRC's top ten
• Natasha Stott Despoja AM appointed Australia’s Ambassador for Women and Girls
• Governor of Victoria, the Honorable Mr Alex Chernov AC QC visits Burnet
• Burnet strengthens collaborations in China
• Congratulations to Burnet's NHMRC grant recipients
• Macquarie Group Foundation supports Burnet Institute
• Disappointment at coalition's announcement on foreign aid
• Burnet welcomes Labor biotech initiative
• Monash Partners to boost medical research in Victoria
• Children help researchers solve malaria vaccine puzzle
• Coalition’s promise resuscitates medical research reform
• Put politics aside says research community
• Do not resuscitate: the journal impact factor declared dead
• Relief as medical research funding maintained
• Healthy Mothers, Healthy Babies will save lives
• Medical research funding cut back
• McKeon Review released
• Leading international HIV researcher, Professor Kenneth Mayer presents at Burnet
• Global Fund visits Burnet
• New leadership team for Centre for International Health
• Melbourne emerging as a 'world centre' for medical research
• Government and community can do more to end HIV
• Research a key weapon in turning the tide against HIV
• Very positive meeting with Myanmar Health Minister
• Fostering closer ties with Myanmar in malaria research
• Maternal and child health programs making a difference
• Burnet delegation honoured to meet Aung San Suu Kyi
• Burnet delegation in Myanmar holding high-level talks with senior health officials
• Coalition commitment to medical research welcome

2012 (12)

• Brendan Crabb to lead medical research peak body
• Research support a key weapon in fight against malaria drug resistance
• New fund launched to help Australia's young researchers
• Report on PNG HIV programs highlight need for research
• Burnet Director takes up key international vaccine post
• Visit to Papua New Guinea reaffirms Burnet's commitment
• Appeal - just $50,000 from reaching our target
• Burnet Chair calls for radical reform of research funding
• The 'missing pieces' of malaria research
• Investment in HIV research saves lives and money
• International Women's Day: the role of female scientists
• World leading malaria researchers swarm into Lorne

2011 (2)

• World Malaria Day
• Burnet signs two year Cooperation Agreement with TIbet Autonomous Region of China