Using malaria (the most important parasitic pathogen in pregnancy) as a model, we aim to address fundamental questions on the modulation of antibody acquisition and maintenance during pregnancy and assess the ability to boost antibody responses upon re-exposure to pathogens in pregnant women.
Using samples from several established longitudinal cohorts of pregnant women and infants in Asia and Africa, we will address questions of antibody acquisition and maintenance through high-throughput antibody assays and epidemiological analyses.
This research will improve our understanding of the development and maintenance of immunity against infectious diseases in pregnant women and the susceptibility of pregnant women to infectious pathogens. The findings will enable us to develop epidemiological frameworks for further comprehensive immunological studies of malaria and other pathogens in pregnant and non-pregnant individuals, assess the usefulness of sero-epidemiological tools for population sentinel surveillance in this high-risk group, and inform vaccine development of candidate malaria vaccines for the use in pregnant women.
- National Health and Medical Research Council
- Shoklo Malaria Research Unit, Thailand
- Mahidol Oxford Research Unit, Thailand
- The University of Melbourne, Australia
Meet the project team. Together, we are translating research into better health, for all.