This study aimed to assess the feasibility, acceptability, effectiveness, and cost-effectiveness of decentralized community-based POC testing and DAA therapy for hepatitis C among people who inject drugs and the general population in Yangon, Myanmar.
This was a feasibility study with two sites:
- Thingangyun Key Population Service Centre (Burnet Institute, serving people who inject drugs primarily), No.63B, Ground Floor, Yadanar Thukha Street, Thingangyun Township, Yangon
- Than Sitt Charity Liver Clinic – 1 Yangon (Myanmar Liver Foundation, serving general population), No.33-35, Ground Floor, Pathein Street, Sanchaung Township, Yangon
Study inclusion criteria:
- Aged ≥18 years
- Attendance at study site
- Willing and able to provide written informed consent
Study exclusion criteria:
- Confirmed HCV RNA positive result (chronic HCV infection) prior to study recruitment
- Treatment experienced (either DAA or pegylated interferon)
- HBV infected
- HIV infected
- eGFR <30
- Active tuberculosis (if known active tuberculosis or as per symptom screening assessment)
- Pregnant women
- Serious drug-drug interaction with sofosbuvir/daclatasvir, or a drug that the patient is unwilling or unable to stop taking.
- Patients with confirmed HCV RNA positive results received standard of care in Myanmar. This involved receiving services provided through the government testing and treatment program or through philanthropic services providing testing and treatment.
January 2019 – September 2020
The study protocol, site-specific informed consent forms, recruitment materials, as well as any subsequent modifications, are approved by Department of Medical Research Institutional Review Board in Myanmar and Alfred Ethics Committee in Melbourne.
Written informed consent was obtained from every study participant.
The results was submitted for publication in peer-reviewed journals and abstracts submitted for relevant conference presentations. No identifying information from study participants was included in any publications, reports or presentations. Results presented only contained aggregate data.
The results of this study informed any potential scale-up of community-based primary care provision of hepatitis C services in Myanmar and other resource-constrained settings.
Results from the CT2 Study were presented at the EASL ILC Virtual Event in August 2020. The summary findings were presented to key stakeholders at the dissemination workshop in October 2020. The Summary Report is now available online on this page.
The findings of CT2 were presented at the INHSU 2019, APASL 2020 and EASL 2020 conferences.
The findings were disseminated to Myanmar Ministry of Health and Sports and key stakeholders. Summary Report is available online now.
CT2 study protocol paper has been published at the peer-reviewed journal JMIR.
Further publications covering the results of this study was made available in 2021. Download and read the CT2 Study Summary Report here.
- Unitaid through the Foundation of Innovative and New Diagnostic (FIND)
- Myanmar Liver Foundation
- National Hepatitis Control Program
- Ministry of Health and Sports
Meet the project team. Together, we are translating research into better health, for all.