We aim to understand the biology underpinning malaria parasite virulence and use this knowledge to aid our discovery and development of novel antimalarials that reduce the parasites’ ability to harm its human host.
2009–ongoing
We perform a range of biochemical, cell biological and plate-based assays to understand basic parasite biology and virulence. We have developed a novel luminescence-based screening platform to discover novel antimalarials that target parasite components that are essential for parasite survival.
Better, safer, and cheaper antimalarial drugs would benefit endemic communities around the world and could accelerate malaria elimination. The research will also provide new knowledge about parasite biology that could inform future treatment options.
Associate Professor Paul Gilson
Contact Associate Professor Paul Gilson for more information about this project.
Funding
Partners
- National Health and Medical Research Council (NHMRC)
Partners +
Collaborators
- Deakin University (Tania de Koning-Ward)
- WEHI (Brad Sleebs, William Nguyen)
- Deakin University/Burnet Institute (Alyssa Barry)
- Monash University (Darren Creek, Ghizal Siddiqui)
Project
Team
Meet the project team. Together, we are translating research into better health, for all.
Publications
VIEW ALL RESEARCHGabriela M, Barnes CBG, Leong D, Sleebs BE, Schneider MP, Littler DR, Crabb BS, de Koning-Ward TF, Gilson PR
- 05 Nov 2023
Jonsdottir TK, Elsworth B, Cobbold S, Gabriela M, Ploeger E, Parkyn Schneider M, Charnaud SC, Dans MG, McConville M, Bullen HE, Crabb BS, Gilson PR
- PLoS pathogens
- 31 Jul 2023
Schneider MP, Looker O, Rebelo M, Khoury DS, Dixon MWA, Oeuvray C, Crabb BS, McCarthy J, Gilson PR
- Frontiers in cellular and infection microbiology
- 29 Jun 2023
Ling DB, Nguyen W, Looker O, Razook Z, McCann K, Barry AE, Scheurer C, Wittlin S, Famodimu MT, Delves MJ, Bullen HE, Crabb BS, Sleebs BE, Gilson PR
- ACS infectious diseases
- 28 Aug 2023
Gabriela M, Matthews KM, Boshoven C, Kouskousis B, Jonsdottir TK, Bullen HE, Modak J, Steer DL, Sleebs BE, Crabb BS, de Koning-Ward TF, Gilson PR
- PLoS pathogens
- 22 Feb 2022
Bullen HE, Sanders PR, Dans MG, Jonsdottir TK, Riglar DT, Looker O, Palmer CS, Kouskousis B, Charnaud SC, Triglia T, Gabriela M, Parkyn Schneider M, Chan JA, de Koning-Ward TF, Baum J, Kazura JW, Beeson JG, Cowman AF, Gilson PR, Crabb BS
- Molecular microbiology
- 25 Apr 2022
Looker O, Dans MG, Bullen HE, Sleebs BE, Crabb BS, Gilson PR
- Traffic (Copenhagen, Denmark)
- 15 Aug 2022
Jonsdottir TK, Counihan NA, Modak JK, Kouskousis B, Sanders PR, Gabriela M, Bullen HE, Crabb BS, de Koning-Ward TF, Gilson PR
- Cellular microbiology
- 03 May 2021
Jonsdottir TK, Gabriela M, Crabb BS, F de Koning-Ward T, Gilson PR
- Trends in parasitology
- 10 May 2021
Jonsdottir TK, Gabriela M, Gilson PR
- Advances in experimental medicine and biology
- 28 Sep 2021
Sanders PR, Dickerman BK, Charnaud SC, Ramsland PA, Crabb BS, Gilson PR
- Journal of biochemistry
- 03 Apr 2019
Chisholm SA, Kalanon M, Nebl T, Sanders PR, Matthews KM, Dickerman BK, Gilson PR, de Koning-Ward TF
- The FEBS journal
- 20 Apr 2018
Charnaud SC, Jonsdottir TK, Sanders PR, Bullen HE, Dickerman BK, Kouskousis B, Palmer CS, Pietrzak HM, Laumaea AE, Erazo AB, McHugh E, Tilley L, Crabb BS, Gilson PR
- Traffic (Copenhagen, Denmark)
- 23 May 2018
Marapana DS, Dagley LF, Sandow JJ, Nebl T, Triglia T, Pasternak M, Dickerman BK, Crabb BS, Gilson PR, Webb AI, Boddey JA, Cowman AF
- Nature microbiology
- 20 Aug 2018
Charnaud SC, Kumarasingha R, Bullen HE, Crabb BS, Gilson PR
- PloS one
- 15 Nov 2018