Background
After completing her Bachelor of Biomedical Science degree in 2006, Hayley went on to pursue her Honours and PhD degrees in the laboratory of Professor Brendan Crabb at the Walter and Eliza Hall Institute and later at the Burnet Institute. Her work centered on deciphering the roles of novel membrane protein complexes in the malaria parasite Plasmodium falciparum, specifically the export machinery termed PTEX.
After completing her PhD studies, Hayley moved to the laboratory of Professor Dominique Soldati-Favre at the University of Geneva, Switzerland where she continued her research on model Apicomplexan parasite Toxoplasma gondii. Her she deciphered the signaling mechanisms underpinning a key step in the invasion process of T. gondii.
In late 2015 Hayley moved back to the Burnet Institute in the laboratory of Professor Brendan Crabb and Dr Paul Gilson, whereupon she initiated mechanism of action studies on the WEB series of compounds, and investigations into novel aspect of protein export.
Qualifications
- 2012: PhD in parasitology (Plasmodium falciparum) Burnet Institute and WEHI, Victoria, Australia.
- 2015: Masters in Public Health, The University of Newcastle
- 2007: Bachelor of Science (Honours), WEHI
- 2006: Bachelor of Biomedical Science, The University of Melbourne
Awards
- 2021: FREDA funding
- 2021: Margaret Harrison Parental Leave Grant
- 2020: Beever Fellowship
- 2020: NHMRC Ideas grant–Discovering how a novel anti-malarial drug series rapidly kills parasites
- 2019: Geoffrey Connard Travel Award
- 2015: Fondation Gertrude von Meissner award (not accepted)
- 2014: EMBO short term fellowship (not accepted)
- 2012: OzeMalAR travel fellowship
- 2011: Australian Society for Parasitology student travel award
- 2011: Miller foundation biomedical research travel award-Burnet Institute
- 2010: Victorian Infection and Immunity network student symposium best speaker award
- 2009: Australian Society for Parasitology student travel award
- 2008-2012: Australian Postgraduate Award-University of Melbourne
- 2007: Alan W. Harris Honors scholarship- The Walter and Eliza Hall Institute
- 2007: The University of Melbourne Honors scholarship
Publications (20)
2022 (3)
- The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites.
Looker O, Dans MG, Bullen HE, Sleebs BE, Crabb BS, Gilson PR
Traffic. 2022 Sep; 23(9):442-461
- The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture.
Bullen HE, Sanders PR, Dans MG, Jonsdottir TK, Riglar DT, Looker O, Palmer CS, Kouskousis B, Charnaud SC, Triglia T, Gabriela M, Schneider MP, Chan JA, de Koning-Ward TF, Baum J, Kazura JW, Beeson JG, Cowman AF, Gilson PR, Crabb BS
Mol Microbiol. 2022 Apr; 117(5):1245-1262
- A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell.
Gabriela M, Matthews KM, Boshoven C, Kouskousis B, Jonsdottir TK, Bullen HE, Modak J, Steer DL, Sleebs BE, Crabb BS, Koning-Ward TF, Gilson PR
PLoS Pathog. 2022 Feb; 18(2):e1009977
2021 (2)
- Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity.
Ashton TD, Ngo A, Favuzza P, Bullen HE, Gancheva MR, Romeo O, Parkyn Schneider M, Nguyen N, Steel RWJ, Duffy S, Lowes KN, Sabroux HJ, Avery VM, Boddey JA, Wilson DW, Cowman AF, Gilson PR, Sleebs BE
Bioorg Chem. 2021 Sep; 117:105359
- Characterisation of complexes formed by parasite proteins exported into the host cell compartment of Plasmodium falciparum infected red blood cells.
Jonsdottir TK, Counihan NA, Modak JK, Kouskousis B, Sanders PR, Gabriela M, Bullen HE, Crabb BS, de Koning-Ward TF, Gilson PR
Cell Microbiol. 2021 Mar; 23(8):e13332
2019 (3)
- Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes.
Wilde ML, Triglia T, Marapana D, Thompson JK, Kouzmitchev AA, Bullen HE, Gilson PR, Cowman AF, Tonkin CJ
MBio. 2019 Oct; 10(5):e01972-19
- A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4.
Gilson PR, Kumarasingha R, Thompson J, Zhang X, Penington JS, Kalhor R, Bullen HE, Lehane AM, Dans MG, de Koning-Ward TF, Holien JK, Soares da Costa TP, Hulett MD, Buskes MJ, Crabb BS, Kirk K, Papenfuss AT, Cowman AF, Abbott BM
Sci Rep. 2019 Jul; 9(1):10292
- The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid.
Bullen HE, Bisio H, Soldati-Favre D
PLoS Pathog. 2019 May; 15(5):e1007670
2018 (2)
- Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export.
Charnaud SC, Kumarasingha R, Bullen HE, Crabb BS, Gilson PR
PLoS One. 2018 Nov; 13(11):e0204785
- Spatial organisation of protein export in malaria parasite blood stages.
Charnaud SC, Jonsdottir TK, Sanders PR, Bullen HE, Dickerman BK, Kouskousis B, Palmer CS, Pietrzak HM, Laumaea AE, Erazo AB, McHugh E, Tilley L, Crabb BS, Gilson PR
Traffic. 2018 Apr; 19(8):605-623
2017 (2)
- Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate.
Counihan N, Chisholm SA, Bullen HE, Srivastava A, Sanders PR, Jonsdottir TK, Weiss GE, Ghosh S, Crabb BS, Creek DJ, Gilson PR, de Koning-Ward TF
eLife. 2017 Mar; 6(pii):e23217
- Optimization of 2-anilino 4-amino substituted quinazolines into potent antimalarial agents with oral in vivo activity.
Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Sabroux H, Crabb BS, Avery VM, Cowman AF, Sleebs BE
J Med Chem. 2017 Jan; 60(3):1171-1188
2016 (3)
- Disrupting the allosteric interaction between the Plasmodium falciparum cAMP-dependent kinase and its regulatory subunit.
Littler DR, Bullen HE, Harvey KL, Beddoe T, Crabb BS, Rossjohn J, Gilson PR
J Biol Chem. 2016 Dec; 291(49):25375-25386
- A central role for phosphatidic acid as a lipid mediator of regulated exocytosis in Apicomplexa.
Bullen HE, Soldati-Favre D
FEBS Lett. 2016 Jul; 590(15):2469-2481
- Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150.
Elsworth B, Sanders PR, Nebl T, Batinovic S, Kalanon M, Nie CQ, Charnaud SC, Bullen HE, de Koning Ward TF, Tilley L, Crabb BS, Gilson PR
Cell Microbiol. 2016 Mar; 18(11):1551-1569
2013 (2)
- Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes.
Riglar DT, Rogers KL, Hanssen E, Turnbull L, Bullen HE, Charnaud SC, Przyborski J, Gilson PR, Whitchurch CB, Crabb BS, Baum J, Cowman AF
Nat Commun. 2013 Jan; 4:1415
- Host cell remodelling and protein trafficking.
Haase S, Bullen HE, Charnaud SC, Crabb BS, Gilson PR, de Koning-Ward TF
in Malaria Parasites: Comparative Genomics , Evolution and Molecular Biology Ed. Carlton JM, Perkins SL, Deitsch KW. 2013 Jan; pp:199-219
2012 (2)
- Recent insights into the export of PEXEL/HTS-motif containing proteins in Plasmodium parasites.
Bullen HE, Crabb BS, Gilson PR
Curr Opin Microbiol. 2012 Oct; 152(6):699-704
- Biosynthesis, localisation and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins; PTEX.
Bullen HE, Charnaud SC, Kalanon M, Riglar DT, Dekiwadia C, Kangwanrangsan N, Torii M, Tsuboi T, Baum J, Ralph SA, Cowman AF, de Koning-Ward TF, Crabb BS, Gilson PR
J Biol Chem. 2012 Jan; 287(11):7871-7884
2009 (1)
News Articles (5)
2022 (2)
2020 (2)
2019 (1)
