Background

An ARC and NHMRC research fellow, and a public health physician, Professor Beeson completed his medical degree at Monash University in 1992.

Based at The Walter and Eliza Hall Institute of Medical Research with field work at the Queen Elizabeth Central Hospital and Wellcome Trust Clinical Research Program, Malawi his thesis titled ‘Mechanisms of placental infection by Plasmodium falciparum,’ commenced in February 1997 and passed in January 2001 through the University of Melbourne.

Following postgraduate specialty training as a public health physician in 2001, he headed a research group at the Walter and Eliza Hall Institute from 2004-2010. In January 2011 he joined Burnet Institute.

Professor Beeson has worked in malaria research in Africa and Asia for 20 years, including Malawi, Kenya, Papua New Guinea and Thailand.

His research group primarily focuses on understanding how malaria causes disease in people and how immunity to malaria develops, and on the development of interventions to reduce malaria such as vaccines or public health programs. Their research currently involves clinical and population studies in Papua New Guinea, Africa and Asia.

With a particular interest in the affects of malaria in pregnancy, and maternal health more broadly, Professor Beeson completed his PhD thesis on malaria in pregnancy, which included studies in Malawi, Central Africa.

This work has highlighted the challenge of improving maternal health in resource-poor countries with a high burden of disease, emphasising the need for programs and interventions that address multiple causes of poor maternal health rather than specific diseases in isolation.

Appointments

• 2017: Deputy Director (People), Burnet Institute
• 2014: Head, Centre for Biomedical Research, Burnet Institute
• 2013: Co-Head, Centre for Biomedical Research, Burnet Institute
• 2012: Adjunct Professor to the Department of Microbiology, Monash University
• 2011: Head, Centre for Immunology, Burnet Institute
• 2011: Principal, Maternal and Child Health, Burnet Institute
• 2011: Head, Beeson Laboratory, Burnet Institute

Qualifications

• 2001: PhD, University of Melbourne, Australia
• 1992: MB BS (Hon) Monash University, Australia
• 1990: B.Med.Sc. (Hon) Monash University, Australia

Professional Affiliations

• 2001: Fellow of the Australasian Faculty of Public Health Medicine, Royal Australasian College of Physicians, (Public Health Physician)
• 1998-2001: Advanced Fellowship Training Program. Admitted as a Fellow of the Faculty, April 2001.
• 1992: Registered Medical Practitioner, Medical Practitioners Board of Victoria
• Member of the Australasian Society of Infectious Diseases
• Member of the Australian Society for Parasitology
• Member of the American Society for Tropical Medicine and Hygiene

Awards

• 2007: Cosmos Science Magazine Bright Sparks Award (A listing of 10 leading Australian researchers under 40)
• 2006: Burnet Prize, Walter and Eliza Hall Institute
• 2002: Chancellors Prize for most outstanding PhD thesis, University of Melbourne,
• 2001: Premier’s Award for Medical Research, State Government of Victoria, Australia

Projects (12)

Current (11)

• Clinical studies on malaria
  The negative consequences of malaria and how to prevent them in children and pregnant women.
• Developing vaccines against malaria
  This project aims to identify key antigens and specific epitopes that are targets of protective immunity.
• Discovering the mechanisms and targets of immunity against malaria
  Identifying the key targets of protective immunity in people who live in malaria-endemic regions.
• Functional antibody responses to malaria vaccine candidates
  Understanding how functional immunity develops to potential malaria vaccine candidates.
• Healthy Mothers, Healthy Babies
  A collaborative research program aimed at providing life-saving health care for women and children in PNG.
• HMHB: The impact of nutrition, malaria and STIs on pregnant women and infants
  Determining the major preventable causes of poor maternal health and low birth weight of babies in PNG.
• IgG subclasses and immunity to malaria
  This project focuses on the importance of antibody subclass for immunity malaria.
• Immunity to malaria during pregnancy
  How are pregnant women affected by infectious diseases such as malaria?
• Major advances in understanding malaria immunity and biology
  Identifying key targets of immunity, the mechanisms mediating immunity, and how it is acquired.
• New treatments for malaria
  In response to the need for new anti-malarial drugs to combat drug resistance, identifying and developing novel compounds that inhibit replication of Plasmodium parasites is required.Full details to follow
• Vaccines against Plasmodium vivax and P. falciparum malaria
  This involves identifying and prioritising candidate antigens for vaccine development.

Past (1)

• Effectiveness of repellent on malaria incidence in SE Myanmar
  A project to determine whether repellent delivered by volunteers will reduce malaria incidence.

Publications (188)

2019 (3)

• Challenges and strategies for developing efficacious and long-lasting malaria vaccines.
  Beeson JG, Kurtovic L, Dobaño C, Opi DH, Chan JA, Feng G, Good MF, Reiling L, Boyle MJ
  Sci Transl Med. 2019 Jan; 11(474)
• Antibody Targets on the Surface of Plasmodium falciparum-Infected Erythrocytes That Are Associated With Immunity to Severe Malaria in Young Children.
  Chan JA, Boyle MJ, Moore KA, Reiling L, Lin Z, Hasang W, Avril M, Manning L, Mueller I, Laman M, Davis T, Smith JD, Rogerson SJ, Simpson JA, Fowkes FJI, Beeson JG
  J Infect Dis. 2019 Jan; Epub ahead of print
• Acquisition of Antibodies Against Endothelial Protein C Receptor-Binding Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Severe Malaria.
  Rambhatla JS, Turner L, Manning L, Laman M, Davis TME, Beeson JG, Mueller I, Warrel J, Theander TG, Lavstsen T, Rogerson SJ
  J Infect Dis. 2019 Jan; Epub ahead of print

2018 (20)

• Effectiveness of repellent delivered through village health volunteers on malaria incidence in villages in South-East Myanmar: a stepped-wedge cluster-randomised controlled trial protocol.
  Win Han Oo, Cutts JC, Agius PA, Kyaw Zayar Aung, Poe Poe Aung, Aung Thi, Nyi Nyi Zaw, Htin Kyaw Thu, Wai Yan Min Htay, Ataide R, O'Flaherty K, Ai Pao Yawn, Aung Paing Soe, Beeson JG, Crabb B, Pasricha N, Fowkes FJI
  BMC Infect Dis. 2018 Dec; 18(1):663
• KILchip v1.0: A novel Plasmodium falciparum merozoite protein microarray to facilitate malaria vaccine candidate prioritization.
  Kamuyu G, Tuju J, Kimathi R, Mwai K, Mburu J, Kibinge N, Kwan MC, Hawkings S, Yaa R, Chepsat E, Njunge JM, Chege T, Guleid F. Rosenkranz M, Kariuki CK, Frank R, Kinyanjui SM, Murungi LM, Bejon P, Farnert A, Tetteh KKA, Beeson JG, Conway DJ, Marsh K, Rayner JC, Osier FHA
  Front Immunol. 2018 Dec; 9:2866
• Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia.
  Oyong DA, Kenangalem E, Poespoprodjo JR, Beeson JG, Anstey NM, Price RN, Boyle MJ
  JCI Insight. 2018 Nov; 3(22):e124854
• Iron deficiency during pregnancy is associated with a reduced risk of adverse birth outcomes in a malaria-endemic area in a longitudinal cohort study.
  Fowkes FJI, Moore KA, Opi DH, Simpson JA, Langham F, Stanisic DI, Ura A, King CL, Siba PM, Mueller I, Rogerson SJ, Beeson JG
  BMC Med. 2018 Sep; 16(1):156
• Multiple morbidities in pregnancy: Time for research, innovation, and action.
  Beeson JG, Homer CSE, Morgan C, Menendez C
  PLoS Med. 2018 Sep; 15(9):e1002665
• Cellular dissection of malaria parasite invasion of human erythrocytes using viable Plasmodium knowlesi merozoites.
  Lyth O, Vizcay-Barrena G, Wright KE, Haase S, Mohring F, Najer A, Henshall IG, Ashdown GW, Bannister LH, Drew DR, Beeson JG, Fleck RA, Moon RW, Wilson DW, Baum J
  Sci Rep. 2018 Jul; 8(1):10165
• Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial.
  Jagannathan P, Kakuru A, Okiring J, Muhindo MK, Natureeba P, Nakalembe M, Opira B, Olwoch P, Nankya F, Ssewanyana I, Tetteh K, Drakeley C, Beeson J, Reiling L, Clark TD, Rodriguez-Barraquer I, Greenhouse B, Wallender E, Aweeka F, Prahl M, Charlebois ED, Feeney ME, Havlir DV, Kamya MR, Dorsey G
  PLoS Med. 2018 Jul; 15(7):e1002606
• Factors influencing the induction of high affinity antibodies to Plasmodium falciparum merozoite antigens and how affinity changes over time.
  Tijani MK, Reddy SB, Langer C, Beeson JG, Wahlgren M, Nwuba RI, Persson KEM
  Sci Rep. 2018 Jun; 8(1):9026
• Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG1-4, IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies.
  Ubillos I, Jiménez A, Vidal M, Bowyer PW, Gaur D, Dutta S, Gamain B, Coppel R, Chauhan V, Lanar D, Chitnis C, Angov E, Beeson J, Cavanagh D, Campo JJ, Aguilar R, Dobaño C
  Malar J. 2018 Jun; 17(1):219
• The complement system contributes to functional antibody-mediated responses induced by immunization with Plasmodium falciparum malaria sporozoites.
  Behet MC, Kurtovic L, van Gemert GJ, Haukes CM, Siebelink-Stoter R, Graumans W, van de Vegte-Bolmer MG, Scholzen A, Langereis JD, Diavatopoulos DA, Beeson JG, Sauerwein RW
  Infect Immun. 2018 May; 86(7):e00920-17
• Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children.
  Kurtovic L, Behet MC, Feng G, Reiling L, Chelimo K, Dent AE, Mueller I, Kazura JW, Sauerwein RW, Fowkes FJI, Beeson JG
  BMC Med. 2018 Apr; 16(1):61
• Human immunization with a polymorphic malaria vaccine candidate induced antibodies to conserved epitopes that promote functional antibodies to multiple parasite strains.
  Feng G, Boyle MJ, Cross N, Chan JA, Reiling L, Osier F, Stanisic D, Mueller I, Anders RF, McCarthy JS, Richards JS, Beeson JG
  J Infect Dis. 2018 Mar; 218(1):35-43
• Proteome-wide mapping of immune features onto Plasmodium protein three-dimensional structures.
  Guy AJ, Irani V, Beeson JG, Webb B, Sali A, Richards JS, Ramsland PA
  Sci Rep. 2018 Mar; 8(1):4355
• Combating low birth weight due to malaria infection in pregnancy.
  Beeson JG, Scoullar MJL, Boeuf P
  Sci Transl Med. 2018 Mar; 10(431):eaat1506
• Effect of nutrient supplementation on the acquisition of humoral immunity to Plasmodium falciparum in young Malawian children.
  Barua P, Chandrasiri UP, Beeson JG, Dewey KG, Maleta K, Ashorn P, Rogerson SJ
  Malar J. 2018 Feb; 17(1):74
• Establishment of a yeast-based VLP platform for antigen presentation.
  Wetzel D, Rolf T, Suckow M, Kranz A, Barbian A, Chan JA, Leitsch J, Weniger M, Jenzelewski V, Kouskousis B, Palmer C, Beeson JG, Schembecker G, Merz J, Piontek M
  Microb Cell Fact. 2018 Feb; 17(1):17
• Functional conservation of the AMA1 host-cell invasion ligand between P. falciparum and P. vivax: a novel platform to accelerate vaccine and drug development.
  Drew DR, Sanders PR, Weiss G, Gilson PR, Crabb BS, Beeson JG
  J Infect Dis. 2018 Feb; 217(3):498-507
• Identifying Immune Correlates of Protection Against Plasmodium falciparum Through a Novel Approach to Account for Heterogeneity in Malaria Exposure.
  Valmaseda A, Macete E, Nhabomba A, Guinovart C, Aide P, Bardají A, Bassat Q, Nhampossa T, Maculuve S, Casellas A, Quintó L, Sanz S, Jiménez A, Feng G, Langer C, Reiling L, Reddy KS, Pandey A, Chitnis CE, Chauhan VS, Aguilar R, Aponte JJ, Dobaño C, Beeson JG, Gaur D, Menéndez C, Alonso PL, Mayor A
  Clin Infect Dis. 2018 Feb; 66(4):586-593
• Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays.
  Hommel M, Chan JA, Umbers AJ, Langer C, Rogerson SJ, Smith JD, Beeson JG
  Parasit Vectors. 2018 Jan; 11(1):69
• The potential of task shifting selected maternal interventions to auxiliary midwives in Myanmar: a mixed-method study.
  Than KK, Tin KN, La T, Thant KS, Myint T, Beeson JG, Luchters S, Morgan A
  BMC Public Health. 2018 Jan; 18(1):99

2017 (19)

• Sero-catalytic and antibody acquisition models to estimate differing malaria transmission intensities in Western Kenya.
  Weber GE, White MT, Babakhanyan A, Sumba PO, Vulule J, Ely D, John C, Angov E, Lanar D, Dutta S, Narum DL, Horii T, Cowman A, Beeson J, Smith J, Kazura JW, Dent AE
  Sci Rep. 2017 Dec; 7(1):16821
• Impaired placental autophagy in placental malaria.
  Dimasuay KG, Gong L, Rosario F, McBryde E, Spelman T, Glazier J, Rogerson SJ, Beeson JG, Jansson T, Devenish RJ, Boeuf P
  PLoS One. 2017 Nov; 12(11):e0187291
• Identification of heparin modifications and polysaccharide inhibitors of Plasmodium falciparum merozoite invasion that have potential for novel drug development.
  Boyle MJ, Skidmore M, Dickerman B, Cooper L, Devlin A, Yates E, Horrocks P, Freeman C, Chai W, Beeson JG
  Antimicrob Agents Chemother. 2017 Oct; 61(11): e00709-17
• Declining malaria transmission differentially impacts on the maintenance of humoral immunity to Plasmodium falciparum in children.
  Mugyenyi CK, Elliott SR, Yap XZ, Feng G, Boeuf P, Fegan G, Osier FFH, Fowkes FJI, Avril M, Williams TN, Marsh K, Beeson JG
  J Infect Dis. 2017 Oct; 216(7):887-898
• P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission.
  McLean ARD, Stanisic D, McGready R, Chotivanich K, Clapham C, Baiwog F, Pimanpanarak M, Siba P, Mueller I, King CL, Nosten F, Beeson JG, Rogerson S, Simpson JA, Fowkes FJI
  PLoS One. 2017 Oct; 12(10):e0186577
• Declining transmission and immunity to malaria and emerging artemisinin resistance in Thailand: A longitudinal study.
  Ataíde R, Powell R, Moore K, McLean A, Phyo AP, Nair S, White M, Anderson TJ, Beeson JG, Simpson JA, Nosten F, Fowkes FJI
  J Infect Dis. 2017 Sep; 216(6):723-731
• Patterns of protective associations differ for antibodies to P.falciparum-infected erythrocytes and merozoites in immunity against malaria in children.
  Chan JA, Stanisic DI, Duffy MF, Robinson LJ, Lin E, Kazura JW, King CL, Siba PM, Fowkes FJ, Mueller I, Beeson JG
  Eur J Immunol. 2017 Aug; 47(12):2124-2136
• Acquisition, maintenance and adaptation of invasion inhibitory antibodies against Plasmodium falciparum invasion ligands involved in immune evasion.
  Tijani MK, Babalola OA, Odaibo AB, Anumudu CI, Asinobi AO, Morenikeji OA, Asuzu MC, Langer C, Reiling L, Beeson JG, Wahlgren M, Nwuba RI, Persson KEM
  PLoS One. 2017 Aug; 12(8):e0182187
• Dichotomous miR expression and immune responses following primary blood-stage malaria.
  Burel JG, Apte SH, Groves PL, Boyle MJ, Langer C, Beeson JG, McCarthy JS, Doolan DL
  JCI Insight. 2017 Aug; 2(15)::e93434
• The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites.
  Charnaud SC, Dixon MWA, Nie CQ, Chappell L, Sanders PR, Nebl T, Hanssen E, Berriman M, Chan JA, Blanch AJ, Beeson JG, Rayner JC, Przyborski JM, Tilley L, Crabb BS, Gilson PR
  PLoS One. 2017 Jul; 12(7):e0181656
• Determinants of knowledge of critical danger signs, safe childbirth and immediate newborn care practices among auxiliary midwives: a cross sectional survey in Myanmar.
  Than KK, Morgan A, Pham MD, Beeson JG, Luchters S
  BMJ Open. 2017 Jul; 7(6):e017180
• Host age and expression of genes involved in red blood cell invasion in Plasmodium falciparum field isolates.
  Valmaseda A, Bassat Q, Aide P, Cisteró P, Jiménez A, Casellas A, Machevo S, Aguilar R, Sigaúque B, Chauhan VS, Langer C, Beeson J, Chitnis C, Alonso PL, Gaur D, Mayor A
  Sci Rep. 2017 Jul; 7(1):4717
• Prevention of postpartum haemorrhage by community-based auxiliary midwives in hard-to-reach areas of Myanmar: a qualitative inquiry into acceptability and feasibility of task shifting.
  Than KK, Mohamed Y, Oliver V, Myint T, La T, Beeson JG, Luchters S
  BMC Pregnancy Childbirth. 2017 May; 17(1):146
• Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.
  McCallum FJ, Persson KM, Fowkes FJ, Reiling L, Mugyenyi CK, Richards JS, Simpson JA, Williams TN, Gilson PR, Hodder AN, Sanders PR, Anders RF, Narum DL, Chitnis C, Crabb BS, Marsh K, Beeson JG.
  J Leukoc Biol. 2017 Apr; 101(4):913-925
• Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort.
  Ataide R, Ashley EA, Powell R, Chan JA, Malloy MJ, O'Flaherty K, Takashima E, Langer C, Tsuboi T, Dondorp AM, Day NP, Dhorda M, Fairhurst RM, Lim P, Amaratunga C, Pukrittayakamee S, Hien TT, Htut Y, Mayxay M, Faiz MA, Beeson JG, Nosten F, Simpson JA, White NJ, Fowkes FJ
  PNAS. 2017 Mar; 114(13):3515-3520
• Antibody responses to Plasmodium falciparum and Plasmodium vivax and prospective risk of Plasmodium spp. infection postpartum.
  McLean ARD, Boel M, McGready R, Ataide R, Drew D, Tsuboi T, James G. Beeson JG, Francois Nosten, Julie A. Simpson and Freya J. I. Fowkes
  Am J Trop Med Hyg. 2017 Mar; 96(5):1197-1204
• The potential benefit of scaling up malaria prevention to reduce low birth weight in Africa.
  Beeson JG, Simpson JA
  PLoS Med. 2017 Feb; 14(2):e1002244
• Plasmodium vivax vaccine research - we've only just begun.
  Tham WH, Beeson JG, Rayner JC
  Int J Parsitol. 2017 Feb; 47(2-3):111-118
• Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight.
  Dimasuay KG, Aitken EH, Rosario F, Njie M, Glazier J, Rogerson SJ, Fowkes FJ, Beeson JG, Powell T, Jansson T, Boeuf P
  BMC Med. 2017 Jan; 15(1):1

2016 (19)

• Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion.
  Johnson S, Rahmani R, Drew DR, Williams MJ, Wilkinson M, Tan YH, Huang JX, Tonkin CJ, Beeson JG, Baum J, Smith BJ, Baell JB
  J Med Chem. 2016 Dec; 59(24):10994-11005
• Evaluating complement-mediated humoral immunity to P. falciparum blood stages.
  Boyle MJ, Reiling L, Beeson JG
  eBiomedicine. 2016 Dec; 14:9-10
• Association between malaria immunity and pregnancy outcomes among Malawian pregnant women receiving nutrient supplementation.
  Chandrasiri UP, Fowkes FJ, Beeson JG, Richards JS, Kamiza S, Maleta K, Ashorn P, Rogerson SJ
  Malar J. 2016 Nov; 15(1):547
• A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens.
  Drew DR, Wilson DW, Elliott SR, Cross N, Terheggen U, Hodder AN, Siba PM, Chelimo K, Dent AE, Kazura JW, Mueller I, Beeson JG
  BMC Med. 2016 Sep; 14(1):144
• The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria.
  Weaver R, Reiling L, Feng G, Drew DR, Mueller I, Siba PM, Tsuboi T, Richards JS, Fowkes FJ, Beeson JG
  Sci Rep. 2016 Sep; 6:33094
• Antibody responses to Plasmodium falciparum and Plasmodium vivax blood-stage and sporozoite antigens in the postpartum period.
  McLean AR, Boel ME, McGready R, Ataide R, Drew D, Tsuboi T, Beeson JG, Nosten F, Simpson JA, Fowkes FJ
  Sci Rep. 2016 Aug; 6:32159
• Functional Antibodies and Protection against Blood-stage Malaria.
  Teo A, Feng G, Brown GV, Beeson JG, Rogerson SJ
  Trends Parasitol. 2016 Aug; 32(11):887-898
• The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact.
  Boeuf P, Drummer HE, Richards JS, Scoullar MJ, Beeson JG
  BMC Med. 2016 Aug; 14(1):112
• Structure-activity studies of beta-hairpin peptide inhibitors of the Plasmodium falciparum AMA1-RON2 interaction.
  Wang G, Drinkwater N, Drew DR, MacRaild CA, Chalmers DK, Mohanty B, Lim SS, Anders RF, Beeson JG, Thompson PE, McGowan S, Simpson JS, Norton RS, Scanlon MJ
  J Mol Biol. 2016 Jul; 428(20):3986-8
• A malaria vaccine in children with HIV.
  Beeson JG, Fowkes FJI
  Lancet Infect Dis. 2016 Jul; 16(10):1087-1089
• Infectivity of Plasmodium falciparum in malaria-naive individuals is related to knob expression and cytoadherence of the parasite.
  Stanisic DI, Gerrard J, Fink J, Griffin PM, Liu XQ, Sundac L, Sekuloski S, Rodriguez IB, Pingnet J, Yang Y, Zhou Y, Trenholme KR, Wang CY, Hackett H, Chan JA, Langer C, Hanssen E, Hoffman SL, Beeson JG, McCarthy JS, Good MF
  Infect Immun. 2016 Jul; 84(9):2689-2696
• A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies.
  Chan JA, Howell KB, Langer C, Maier AG, Hasang W, Rogerson SJ, Petter M, Chesson J, Stanisic DI, Duffy MF, Cooke BM, Siba PM, Mueller I, Bull PC, Marsh K, Fowkes FJ, Beeson JG
  Cell Mol Life Sci. 2016 May; 73(21):4141-4158
• Merozoite antigens of Plasmodium falciparum elicit strain-transcending opsonizing immunity.
  Hill DL, Wilson DW, Sampaio NG, Eriksson EM, Ryg-Cornejo V, Harrison GL, Uboldi AD, Robinson LJ, Beeson JG, Siba P, Cowman AF, Hansen DS, Mueller I, Schofield L
  Infect Immun. 2016 May; 84(8):2175-2184
• High resolution FTIR imaging provides automated discrimination and detection of single malaria parasite infected erythrocytes on glass.
  Perez-Guaita D, Andrew D, Heraud P, Beeson J, Anderson D, Richards J, Wood BR
  Faraday Discuss. 2016 Apr; 187:341-352
• Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2.
  Krishnarjuna B, Andrew D, MacRaild CA, Morales RA, Beeson JG, Anders RF, Richards JS, Norton RS
  Sci Rep. 2016 Feb; 6:20613
• Maternal-foetal transfer of Plasmodium falciparum and Plasmodium vivax antibodies in a low transmission setting.
  Charnaud SC, McGready R, Herten-Crabb A, Powell R, Guy A, Langer C, Richards JS, Gilson PR, Chotivanich K, Tsuboi T, Narum DL, Pimanpanarak M, Simpson JA, Beeson JG, Nosten F, Fowkes FJ
  Sci Rep. 2016 Feb; 6:20859
• Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria.
  Beeson JG, Drew DR, Boyle MJ, Feng G, Fowkes FJ, Richards JS
  FEMS Microbiol Rev. 2016 Jan; 40(3):343-372
• Immunity to malaria in an era of declining malaria transmission.
  Fowkes FJ, Boeuf P, Beeson JG
  Parasitology. 2016 Jan; 143(2):139-153
• Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort.
  Dent AE, Malhotra I, Wang X, Babineau D, Yeo KT, Anderson T, Kimmel RJ, Angov E, Lanar DE, Narum D, Dutta S, Richards J, Beeson JG, Crabb BS, Cowman AF, Horii T, Muchiri E, Mungai PL, King CL, Kazura JW
  Clin Vaccine Immunol. 2016 Jan; 23(2):104-116

2015 (20)

• Insights into the Immunological Properties of Intrinsically Disordered Malaria Proteins Using Proteome Scale Predictions.
  Guy AJ, Irani V, MacRaild CA, Anders RF, Norton RS, Beeson JG, Richards JS, Ramsland PA
  PLoS One. 2015 Oct; 10(10):e0141729
• Designing malaria vaccines to circumvent antigen variability.
  Ouattara A, Barry AE, Dutta S, Remarque EJ, Beeson JG, Plowe CV
  Vaccine. 2015 Oct; 33(52):7506-7512
• Malaria and age variably but critically control Hepcidin throughout childhood in Kenya.
  Atkinson SH, Uyoga SM, Armitage AE, Khandwala S, Mugyenyi CK, Bejon P, Marsh K, Beeson JG, Prentice AM, Drakesmith H, Williams TN
  EBioMedicine. 2015 Oct; 2(10):1478-1486
• Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities.
  Helb DA, Tetteh KK, Felgner PL, Skinner J, Hubbard A, Arinaitwe E, Mayanja-Kizza H, Ssewanyana I, Kamya MR, Beeson JG, Tappero J, Smith DL, Crompton PD, Rosenthal PJ, Dorsey G, Drakeley CJ, Greenhouse B
  Proc Natl Acad Sci U S A. 2015 Jul; 112(32):E4438-E4447
• Malaria eradication and elimination: views on how to translate a vision into reality.
  Tanner M, Greenwood B, Whitty CJ, Ansah EK, Price RN, Dondorp AM, von Seidlein L, Baird JK, Beeson JG, Fowkes FJ, Hemingway J, Marsh K, Osier F
  BMC Med. 2015 Jul; 13:167
• Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.
  Wilson DW, Goodman CD, Sleebs BE, Weiss GE, de Jong NW, Angrisano F, Langer C, Baum J, Crabb BS, Gilson PR, McFadden GI, Beeson JG
  BMC Biol. 2015 Jul; 13(1):52
• CD14hi CD16+ monocytes phagocytose antibody-opsonised Plasmodium falciparum infected erythrocytes more efficiently than other monocyte subsets, and require CD16 and complement to do so.
  Zhou J, Feng G, Beeson J, Hogarth PM, Rogerson SJ, Yan Y, Jaworowski A.
  BMC Med. 2015 Jul; 13(1):154
• Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens.
  Reddy SB, Anders RF, Cross N, Mueller I, Senn N, Stanisic DI, Siba PM, Wahlgren M, Kironde F, Beeson JG, Persson KE
  BMC Microbiol. 2015 Jul; 15(1):133
• Acquisition of functional antibodies that block the binding of erythrocyte binding antigen 175 and protection against Plasmodium falciparum malaria in children.
  Irani V, Ramsland PA, Guy AJ, Siba PM, Mueller I, Richards JS, Beeson JG
  Clin Infect Dis. 2015 Jul; 61(8):1244-1252
• The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial.
  Chandrasiri UP, Fowkes FJ, Richards JS, Langer C7, Fan YM, Taylor SM, Beeson JG, Dewey KG, Maleta K, Ashorn P, Rogerson SJ
  Malar J. 2015 May; 14(1):193
• Maximizing antimalarial efficacy and the importance of dosing strategies.
  Beeson JG, Boeuf P, Fowkes FJ
  BMC Med. 2015 May; 13(1):110
• Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases.
  Irani V, Guy AJ, Andrew D, Beeson JG, Ramsland PA, Richards JS
  Mol Immunol. 2015 Apr; 67(2 Pt A):171-182
• Plasmodium vivax malaria: challenges in diagnosis, treatment, and elimination.
  Beeson JG, Chu C, Richards JS, Nosten F, Fowkes FJ
  Pediatr Infect Dis J. 2015 Mar; 34(5):529-531
• Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria.
  Boyle MJ, Reiling L, Feng GQ, Langer C, Osier FH, Aspeling-Jones H, Cheng YS, Stubbs J, Tetteh KKA, Conway DJ, McCarthy JS, Muller I, Marsh K, Anders RF, Beeson JG
  Immunity. 2015 Mar; 42(3):580-590
• Risk factors for malaria and adverse birth outcomes in a prospective cohort of pregnant women resident in a high malaria transmission area of Papua New Guinea.
  Stanisic DI, Moore KA, Baiwog F, Ura A, Clapham C, King CL, Siba PM, Beeson JG, Mueller I, Fowkes FJ, Rogerson SJ
  Trans R Soc Trop Med Hyg. 2015 Mar; 109(5):313-324
• Conformational dynamics and antigenicity in the disordered malaria antigen merozoite surface protein 2.
  MacRaild CA, Zachrdla M, Andrew D, Krishnarjuna B, Nováček J, Žídek L, Sklenář V, Richards JS, Beeson JG, Anders RF, Norton RS
  PLoS One. 2015 Mar; 10(3):e0119899
• Malaria and immunity during pregnancy and postpartum: a tale of two species.
  McLean ARD, Ataide R, Simpson JA, Beeson JG, Fowkes FJ
  Parasitology. 2015 Mar; 142(8):999-1015
• PfRH5 as a candidate vaccine for Plasmodium falciparum malaria.
  Drew DR, Beeson JG
  Trends Parasitol. 2015 Feb; 31(3):87-88
• APTEC: Aptamer-tethered enzyme capture as a novel rapid diagnostic test for malaria.
  Dirkzwager R, Kinghorn A, Richards JS, Tanner JA
  Chem Comm. 2015 Feb; 51(22):4697-4700
• Acquisition of antibodies against Plasmodium falciparum merozoites and malaria immunity in young children: influence of age, force of infection, and magnitude of response.
  Stanisic DI, Fowkes FJ, Koinari M, Javati S, Lin E, Kiniboro B, Richards JS, Robinson LJ, Schofield L, Kazura JW, King CL, Zimmerman P, Felger I, Siba PM, Mueller I, Beeson JG
  Infect Immun. 2015 Feb; 83(2):646-660

2014 (12)

• Subclass responses and their half-lives for antibodies against EBA175 and PfRh2 in naturally acquired immunity against Plasmodium falciparum malaria.
  Ahmed Ismail H, Tijani MK, Langer C, Reiling L, White MT, Beeson JG, Wahlgren M, Nwuba R, Persson KE
  Malar J. 2014 Nov; 13(1):425
• Research priorities for the development and implementation of serological tools for malaria surveillance
  Elliott SR, Fowkes FJI, Richards JS, Reiling L, Drew DR, Beeson JG
  F1000Prime Reports. 2014 Nov; 6:100
• Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines.
  Terheggen U, Drew DR, Hodder AN, Cross NJ, Mugyenyi CK, Barry AE, Anders RF, Dutta S, Osier F, Elliott SR, Senn N, Stanisic DI, Marsh K, Siba PM, Mueller I, Richards JS, Beeson JG
  BMC Med. 2014 Oct; 12(1):183
• Immunodampening to overcome diversity in the malarial vaccine candidate apical membrane antigen 1.
  Harris KS, Adda CG, Khore M, Drew DR, Valentini-Gatt A, Fowkes FJ, Beeson JG, Dutta S, Anders RF, Foley M
  Infect Immun. 2014 Aug; 82(11):4707-4711
• Immunological markers of P. vivax exposure and immunity: A Systematic Review and Meta-analysis
  Cutts J, Powell R, Agius PA, Beeson JG, Simpson JA, Fowkes FJI
  BMC Medicine. 2014 Aug; 12(1):150
• A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors.
  Devine SM, Lim SS, Chandrashekaran IR, MacRaild CA, Drew DR, Debono CO, Lam R, Anders RF, Beeson JG, Scanlon MJ, Scammellsa PJ, Norton RS
  Med Chem Comm. 2014 Jul; Epub ahead of print
• PTEX is an essential nexus for protein export in malaria parasites.
  Elsworth B, Matthews K, Nie CQ, Kalanon M, Charnaud SC, Sanders PR, Chisholm SA, Counihan NA, Shaw PJ, Pino P, Chan J-A, Azevedo MF, Rogerson SJ, Beeson JG, Crabb BS, Gilson PR, de Koning-Ward TF
  Nature. 2014 Jul; 511(7511):587-591
• Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria.
  Osier FH, Feng G, Boyle MJ, Langer C, Zhou J, Richards JS, McCallum FJ, Reiling L, Jaworowski A, Anders RF, Marsh K, Beeson JG
  BMC Med. 2014 Jul; 12(1):108
• Decreasing malaria prevalence and its potential consequences for immunity in pregnant women.
  Teo A, Hasang W, Randall LM, Feng G, Bell L, Unger H, Langer C, Beeson JG, Siba PM, Mueller I, Molyneux ME, Brown GV, Rogerson SJ.
  J Infect Dis. 2014 May; 210(9):1444-1455
• Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates.
  Chan JA, Fowkes FJ, Beeson JG
  Cell Mol Life Sci. 2014 Apr; 71(19):3633-3657
• Correlates of protection for Plasmodium falciparum malaria vaccine development: current knowledge and future research (Book Chapter)
  Beeson JG, Fowkes FJI, Reiling L, Osier FH, Drew DR, Brown GV
  Malaria Vaccine Development: Over 40 Years of Trials and Tribulations. 2014 Apr; Chapter 6:81-104
• Sequential processing of merozoite surface proteins during and after erythrocyte invasion by Plasmodium falciparum.
  Boyle MJ, Langer C, Chan JA, Hodder AN, Coppel RL, Anders RF, Beeson JG
  Infect Immun. 2014 Jan; 82(3):924-936

2013 (12)

• Overcoming Antigenic Diversity by Enhancing the Immunogenicity of Conserved Epitopes on the Malaria Vaccine Candidate Apical Membrane Antigen-1.
  Dutta S, Dlugosz LS, Drew DR, Ge X, Ababacar D, Rovira YI, Moch JK, Shi M, Long CA, Foley M, Beeson JG, Anders RF, Miura K, Haynes JD, Batchelor AH
  PLoS Pathog. 2013 Dec; 9(12):e1003840
• Implications of the licensure of a partially efficacious malaria vaccine on evaluating second-generation vaccines.
  Fowkes FJ, Simpson JA, Beeson JG
  BMC Med. 2013 Oct; 11:232
• Antibodies to Polymorphic Invasion-Inhibitory and Non-Inhibitory Epitopes of Plasmodium falciparum Apical Membrane Antigen 1 in Human Malaria.
  Mugyenyi CK, Elliott SR, McCallum FJ, Anders RF, Marsh K, Beeson JG
  PLoS One. 2013 Jul; 8(7):e68304
• Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.
  Richards JS, Arumugam TU, Reiling L, Healer J, Hodder AN, Fowkes FJ, Cross N, Langer C, Takeo S, Uboldi AD, Thompson JK, Gilson PR, Coppel RL, Siba PM, King CL, Torii M, Chitnis CE, Narum DL, Mueller I, Crabb BS, Cowman AF, Tsuboi T, Beeson JG
  J Immunol. 2013 Jun; 191(2):795-809
• Erythrocyte-Binding Antigens of Plasmodium falciparum Are Targets of Human Inhibitory Antibodies and Function To Evade Naturally Acquired Immunity.
  Persson KE, Fowkes FJ, McCallum FJ, Gicheru N, Reiling L, Richards JS, Wilson DW, Lopaticki S, Cowman AF, Marsh K, Beeson JG
  J Immunol. 2013 Jun; 191(2):785-794
• Acquired antibodies to merozoite antigens in children from Uganda with uncomplicated or severe Plasmodium falciparum malaria.
  Ahmed Ismail H, Ribacke U, Reiling L, Normark J, Egwang T, Kironde F, Beeson JG, Wahlgren M, Persson KE
  Clin Vaccine Immunol. 2013 Jun; 20(8):1170-1180
• T-Helper Cell 2-Driven Immunity in Pregnancy as a Determinant of Antiplasmodial Antibody Half-life Through Regulation of Fc-Receptor-Mediated Clearance - Reply
  Fowkes FJ, Beeson JG
  J Infect Dis. 2013 May; 208(4):705-706
• Antibody boosting and longevity following tetanus immunization during pregnancy.
  Fowkes FJ, McGready R, Johnstone-Robertson S, Nosten F, Beeson JG
  Clin Infect Dis. 2013 Mar; 56(5):749-750
• PfEMP1 as a target of human immunity and a vaccine candidate against malaria.
  Beeson JG, Chan JA, Fowkes FJ
  Expert Rev Vaccines. 2013 Feb; 12(2):105-108
• Does malaria affect placental development? Evidence from in vitro models.
  Umbers AJ, Stanisic DI, Ome M, Wangnapi R, Hanieh S, Unger HW, Robinson LJ, Lufele E, Baiwog F, Siba PM, King CL, Beeson JG, Mueller I, Aplin JD, Glazier JD, Rogerson SJ
  PLoS One. 2013 Jan; 8(1):e55269
• Defining the timing of action of anti-malarial drugs against Plasmodium falciparum.
  Wilson DW, Langer C, Goodman CD, McFadden GI, Beeson JG
  Antimicrob Agents Chemother. 2013 Jan; 57(3):1455-1467
• New approaches to studying Plasmodium falciparum merozoite invasion and insights into invasion biology.
  Boyle MJ, Wilson DW, Beeson JG
  Int J Parasitol. 2013 Jan; 43(1):1-10

2012 (11)

• Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum.
  McMorran BJ, Wieczorski L, Drysdale KE, Chan JA, Huang HM, Smith C, Mitiku C, Beeson JG, Burgio G, Foote SJ
  Science. 2012 Dec; 338(6112):1348-1351
• Defining the Antigenic Diversity of Plasmodium falciparum Apical Membrane Antigen 1 and the Requirements for a Multi-Allele Vaccine against Malaria.
  Drew DR, Hodder AN, Wilson DW, Foley M, Mueller I, Siba PM, Dent AE, Cowman AF, Beeson JG
  PLoS One. 2012 Dec; 7(12):e51023
• Malaria Parasite Signal Peptide Peptidase is an ER-Resident Protease Required for Growth but not for Invasion.
  Marapana DS, Wilson DW, Zuccala ES, Dekiwadia CD, Beeson JG, Ralph SA, Baum J
  Traffic. 2012 Nov; 13(11):1457-1465
• The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria.
  Reiling L, Richards JS, Fowkes FJ, Wilson DW, Chokejindachai W, Barry AE, Tham WH, Stubbs J, Langer C, Donelson J, Michon P, Tavul L, Crabb BS, Siba PM, Cowman AF, Mueller I, Beeson JG
  PLoS One. 2012 Sep; 7(9):e45253
• New insights into acquisition, boosting and longevity of immunity to malaria in pregnant women.
  Fowkes FJ, McGready R, Cross NJ, Hommel M, Simpson JA, Elliott SR, Richards JS, Lackovic K, Viladpai-Nguen J, Narum D, Tsuboi T, Anders RF, Nosten F, Beeson JG
  J Infect Dis. 2012 Sep; 206(10):1612-1621
• Antigenic Characterisation of an Intrinsically Unstructured Protein: Plasmodium falciparum Merozoite Surface Protein 2.
  Adda CG, Macraild CA, Reiling L, Wycherley K, Boyle MJ, Kienzle V, Masendycz P, Foley M, Beeson JG, Norton RS, Anders RF
  Infect Immun. 2012 Sep; 80(12):4177-4185
• Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity.
  Chan JA, Howell KB, Reiling L, Ataide R, Mackintosh CL, Fowkes FJ, Petter M, Chesson JM, Langer C, Warimwe GM, Duffy MF, Rogerson SJ, Bull PC, Cowman AF, Marsh K, Beeson JG
  J Clin Invest. 2012 Sep; 122(9):3227-3238
• Perspectives: The missing pieces.
  Crabb BS, Beeson JG, Amino R, Ménard R, Waters A, Winzeler EA, Wahlgren M, Fidock DA, Nwaka S
  Nature. 2012 Apr; 484(7395):S22-S23
• Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial.
  Senn N, Rarau P, Stanisic DI, Robinson L, Barnadas C, Manong D, Salib M, Iga J, Tarongka N, Ley S, Rosanas-Urgell A, Aponte JJ, Zimmerman PA, Beeson JG, Schofield L, Siba P, Rogerson SJ, Reeder JC, Mueller I
  PLoS Med. 2012 Mar; 9(3):e1001195
• High affinity antibodies to Plasmodium falciparum merozoite antigens are associated with protection from malaria.
  Reddy SB, Anders RF, Beeson JG, Färnert A, Kironde F, Berenzon SK, Wahlgren M, Linse S, Persson KE
  PLoS One. 2012 Feb; 7(2):e32242
• Antibody to P. falciparum in Pregnancy Varies with Intermittent Preventive Treatment Regime and Bed Net Use.
  Aitken EH, Mbewe B, Luntamo M, Kulmala T, Beeson JG, Ashorn P, Rogerson SJ
  PLoS One. 2012 Jan; 7(1):e29874

2011 (9)

• Quantifying the importance of MSP1-19 as a target of growth-inhibitory and protective antibodies against Plasmodium falciparum in humans.
  Wilson DW, Fowkes FJ, Gilson PR, Elliott SR, Tavul L, Michon P, Dabod E, Siba PM, Mueller I, Crabb BS, Beeson JG
  PLoS One. 2011 Nov; 6(11):e27705
• Discovery of GAMA, a Plasmodium falciparum merozoite micronemal protein, as a novel blood-stage vaccine candidate antigen.
  Arumugam TU, Takeo S, Yamasaki T, Thonkukiatkul A, Miura K, Otsuki H, Zhou H, Long CA, Sattabongkot J, Thompson J, Wilson DW, Beeson JG, Healer J, Crabb BS, Cowman AF, Torii M, Tsuboi T
  Infect Immun. 2011 Nov; 79(11):4523-4532
• A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with Montanide(R) ISA 720.
  McCarthy JS, Marjason J, Elliott S, Fahey P, Bang G, Malkin E, Tierney E, Aked-Hurditch H, Adda C, Cross N, Richards JS, Fowkes FJ, Boyle MJ, Long C, Druilhe P, Beeson JG, Anders RF
  PLoS One. 2011 Sep; 6(9):e24413
• IgG against Plasmodium falciparum variant surface antigens and growth inhibitory antibodies in Mozambican children receiving intermittent preventive treatment with sulfadoxine-pyrimethamine.
  Diana Quelhas, Alfons Jimenez, Llorenc Quinto, Elisa Serra-Casas, Alfredo Mayor, Pau Cistero, Laura Puyol, Danny W Wilson, Jack S Richards, Tacilta Nhampossa, Eusebio Macete, Pedro Aide, Inacio Mandomando, Sergi Sanz, John J Aponte, Pedro L Alonso, James G Beeson, Clara Menendez, Carlota Dobano
  Immunobiology. 2011 Jul; 216(7):793-802
• Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasites.
  Sash Lopaticki, Alexander G Maier, Jennifer Thompson, Danny W Wilson, Wai-Hong Tham, Tony Triglia, Alex Gout, Terence P Speed, James G Beeson, Julie Healer, Alan F Cowman
  Infect Immun. 2011 Mar; 79(3):1107-1117
• Placental malaria-associated inflammation disturbs the insulin-like growth factor axis of fetal growth regulation.
  Alexandra J Umbers, Philippe Boeuf, Caroline Clapham, Danielle I Stanisic, Francesca Baiwog, Ivo Mueller, Peter Siba, Christopher L King, James G Beeson, Jocelyn Glazier, Stephen J Rogerson
  J Infect Dis. 2011 Feb; 203(4):561-569
• Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates.
  Marion Avril, Marianne J Hathaway, Anand Srivastava, Sebastien Dechavanne, Mirja Hommel, James G Beeson, Joseph D Smith, Benoit Gamain
  PLoS One. 2011 Feb; 6(2):e16622
• Intermittent preventive treatment to reduce the burden of malaria in children: new evidence on integration and delivery.
  Beeson JG, Rogerson SJ, Mueller I, Richards JS, Fowkes FJI
  PLoS Med. 2011 Feb; 8(2):e1000410
• Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte.
  Riglar DT, Richard D, Wilson DW, Boyle MJ, Dekiwadia C, Turnbull L, Angrisano F, Marapana DS, Rogers KL, Whitchurch CB, Beeson JG, Cowman AF, Ralph SA, Baum J
  Cell Host Microbe. 2011 Jan; 9(1):9-20

2010 (12)

• Evidence that the erythrocyte invasion ligand PfRh2 is a target of protective immunity against Plasmodium falciparum malaria.
  Reiling L, Richards JS, Fowkes FJ, Barry AE, Triglia T, Chokejindachai W, Michon P, Tavul L, Siba PM, Cowman AF, Mueller I, Beeson JG
  J Immunol. 2010 Nov; 185(10):6157-6167
• Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia.
  Richards JS, Stanisic DI, Fowkes FJ, Tavul L, Dabod E, Thompson JK, Kumar S, Chitnis CE, Narum DL, Michon P, Siba PM, Cowman AF, Mueller I, Beeson JG
  Clin Infect Dis. 2010 Oct; 51(8):e50-e60
• Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand.
  Wai-Hong Tham, Danny W Wilson, Sash Lopaticki, Christoph Q Schmidt, Patience B Tetteh-Quarcoo, Paul N Barlow, Dave Richard, Jason E Corbin, James G Beeson, Alan F Cowman
  Proc Natl Acad Sci U S A. 2010 Oct; 107(40):17327-17332
• Minimal association of common red blood cell polymorphisms with Plasmodium falciparum infection and uncomplicated malaria in Papua New Guinean school children.
  Enmoore Lin, Livingstone Tavul, Pascal Michon, Jack S Richards, Elijah Dabod, James G Beeson, Christopher L King, Peter A Zimmerman, Ivo Mueller
  Am J Trop Med Hyg. 2010 Oct; 83(4):828-833
• Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development.
  Michelle J Boyle, Danny W Wilson, Jack S Richards, David T Riglar, Kevin K A Tetteh, David J Conway, Stuart A Ralph, Jake Baum, James G Beeson
  Proc Natl Acad Sci U S A. 2010 Aug; 107(32):14378-14383
• Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays.
  Wilson DW, Crabb BS, Beeson JG
  Malar J. 2010 Jun; 9:152
• Interactions with heparin-like molecules during erythrocyte invasion by Plasmodium falciparum merozoites.
  Boyle MJ, Richards JS, Gilson PR, Chai W, Beeson JG
  Blood. 2010 Jun; 115(22):4559-4568
• Using an improved phagocytosis assay to evaluate the effect of HIV on specific antibodies to pregnancy-associated malaria.
  Ricardo Ataide, Wina Hasang, Danny W Wilson, James G Beeson, Victor Mwapasa, Malcolm E Molyneux, Steven R Meshnick, Stephen J Rogerson
  PLoS One. 2010 May; 5(5):e10807
• Antibodies to chondroitin sulfate A-binding infected erythrocytes: dynamics and protection during pregnancy in women receiving intermittent preventive treatment.
  Elizabeth H Aitken, Bernard Mbewe, Mari Luntamo, Ken Maleta, Teija Kulmala, Marc-James Friso, Freya J I Fowkes, James G Beeson, Per Ashorn, Stephen J Rogerson
  J Infect Dis. 2010 May; 201(9):1316-1325
• Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women.
  Mirja Hommel, Salenna R Elliott, Viju Soma, Greg Kelly, Freya J I Fowkes, Joanne M Chesson, Michael F Duffy, Joseph Bockhorst, Marion Avril, Ivo Mueller, Andrew Raiko, Danielle I Stanisic, Stephen J Rogerson, Joseph D Smith, James G Beeson
  Infect Immun. 2010 May; 78(5):1963-1978
• Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes.
  Marion Avril, Megan M Cartwright, Marianne J Hathaway, Mirja Hommel, Salenna R Elliott, Kathryn Williamson, David L Narum, Patrick E Duffy, Michal Fried, James G Beeson, Joseph D Smith
  Infect Immun. 2010 May; 78(5):2248-2256
• The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis.
  Freya J I Fowkes, Jack S Richards, Julie A Simpson, James G Beeson
  PLoS Med. 2010 Jan; 7(1):e1000218

2009 (7)

• Strain-specific duffy binding protein antibodies correlate with protection against infection with homologous compared to heterologous plasmodium vivax strains in Papua New Guinean children.
  Jennifer L Cole-Tobian, Pascal Michon, Moses Biasor, Jack S Richards, James G Beeson, Ivo Mueller, Christopher L King
  Infect Immun. 2009 Sep; 77(9):4009-4017
• The future for blood-stage vaccines against malaria.
  Jack S Richards, James G Beeson
  Immunol Cell Biol. 2009 Jul; 87(5):377-390
• Cellular tumor necrosis factor, gamma interferon, and interleukin-6 responses as correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea.
  Leanne J Robinson, Marthe C D'Ombrain, Danielle I Stanisic, Jack Taraika, Nicholas Bernard, Jack S Richards, James G Beeson, Livingstone Tavul, Pascal Michon, Ivo Mueller, Louis Schofield
  Infect Immun. 2009 Jul; 77(7):3033-3043
• Antibodies to reticulocyte binding protein-like homologue 4 inhibit invasion of Plasmodium falciparum into human erythrocytes.
  Wai-Hong Tham, Danny W Wilson, Linda Reiling, Lin Chen, James G Beeson, Alan F Cowman
  Infect Immun. 2009 Jun; 77(6):2427-2435
• Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum.
  Christopher J Tonkin, Celine K Carret, Manoj T Duraisingh, Till S Voss, Stuart A Ralph, Mirja Hommel, Michael F Duffy, Liliana Mancio da Silva, Artur Scherf, Alasdair Ivens, Terence P Speed, James G Beeson, Alan F Cowman
  PLoS Biol. 2009 Apr; 7(4):e84
• Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illness.
  Danielle I Stanisic, Jack S Richards, Fiona J McCallum, Pascal Michon, Christopher L King, Sonja Schoepflin, Paul R Gilson, Vincent J Murphy, Robin F Anders, Ivo Mueller, James G Beeson
  Infect Immun. 2009 Mar; 77(3):1165-1174
• Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum.
  Jake Baum, Lin Chen, Julie Healer, Sash Lopaticki, Michelle Boyle, Tony Triglia, Florian Ehlgen, Stuart A Ralph, James G Beeson, Alan F Cowman
  Int J Parasitol. 2009 Feb; 39(3):371-380

2008 (10)

• Recent insights into humoral and cellular immune responses against malaria.
  James G Beeson, Faith H A Osier, Christian R Engwerda
  Trends Parasitol. 2008 Dec; 24(12):578-584
• Acquisition of growth-inhibitory antibodies against blood-stage Plasmodium falciparum.
  Fiona J McCallum, Kristina E M Persson, Cleopatra K Mugyenyi, Freya J I Fowkes, Julie A Simpson, Jack S Richards, Thomas N Williams, Kevin Marsh, James G Beeson
  PLoS One. 2008 Oct; 3(10):e3571
• Antibody-mediated growth inhibition of Plasmodium falciparum: relationship to age and protection from parasitemia in Kenyan children and adults.
  Arlene E Dent, Elke S Bergmann-Leitner, Danny W Wilson, Daniel J Tisch, Rhonda Kimmel, John Vulule, Peter Odada Sumba, James G Beeson, Evelina Angov, Ann M Moormann, James W Kazura
  PLoS One. 2008 Oct; 3(10):e3557
• Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes.
  Alexander G Maier, Melanie Rug, Matthew T O'Neill, Monica Brown, Srabasti Chakravorty, Tadge Szestak, Joanne Chesson, Yang Wu, Katie Hughes, Ross L Coppel, Chris Newbold, James G Beeson, Alister Craig, Brendan S Crabb, Alan F Cowman
  Cell. 2008 Jul; 134(1):48-61
• Characteristics of Plasmodium falciparum-infected-erythrocyte adhesion to chondroitin sulfate.
  James G Beeson
  Infect Immun. 2008 Jun; 76(6):2808; author reply 2808-2808; author reply 2809
• Estimating the burden of global mortality in children aged <5 years by pathogen-specific causes.
  Salenna R Elliott, James G Beeson
  Clin Infect Dis. 2008 Jun; 46(11):1794-1795
• Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development.
  Tania F de Koning-Ward, Damien R Drew, Joanne M Chesson, James G Beeson, Brendan S Crabb
  Mol Biochem Parasitol. 2008 May; 159(1):69-72
• Polymorphic and conserved targets of antibodies against Plasmodium falciparum during pregnancy.
  James G Beeson, Salenna R Elliott, Mirja Hommel
  J Infect Dis. 2008 May; 197(9):1350-1; author reply 1351
• Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line.
  Francisca Yosaatmadja, Katherine T Andrews, Michael F Duffy, Graham V Brown, James G Beeson, Stephen J Rogerson
  Malar J. 2008 Mar; 7:51
• Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies.
  Kristina E M Persson, Fiona J McCallum, Linda Reiling, Nicole A Lister, Janine Stubbs, Alan F Cowman, Kevin Marsh, James G Beeson
  J Clin Invest. 2008 Jan; 118(1):342-351

2007 (6)

• Towards a vaccine against Plasmodium vivax malaria.
  James G Beeson, Brendan S Crabb
  PLoS Med. 2007 Dec; 4(12):e350
• Serum lipoproteins promote efficient presentation of the malaria virulence protein PfEMP1 at the erythrocyte surface.
  Sarah Frankland, Salenna R Elliott, Francisca Yosaatmadja, James G Beeson, Stephen J Rogerson, Akinola Adisa, Leann Tilley
  Eukaryot Cell. 2007 Sep; 6(9):1584-1594
• Structural basis for binding of Plasmodium falciparum erythrocyte membrane protein 1 to chondroitin sulfate and placental tissue and the influence of protein polymorphisms on binding specificity.
  James G Beeson, Katherine T Andrews, Michelle Boyle, Michael F Duffy, Ee Ken Choong, Tim J Byrne, Joanne M Chesson, Alexander M Lawson, Wengang Chai
  J Biol Chem. 2007 Aug; 282(31):22426-22436
• Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa.
  James G Beeson, Francis Ndungu, Kristina E M Persson, Joanne M Chesson, Greg L Kelly, Sophie Uyoga, Sandra L Hallamore, Thomas N Williams, John C Reeder, Graham V Brown, Kevin Marsh
  Am J Trop Med Hyg. 2007 Jul; 77(1):22-28
• The risk of malarial infections and disease in Papua New Guinean children.
  Pascal Michon, Jennifer L Cole-Tobian, Elijah Dabod, Sonja Schoepflin, Jennifer Igu, Melinda Susapu, Nandao Tarongka, Peter A Zimmerman, John C Reeder, James G Beeson, Louis Schofield, Christopher L King, Ivo Mueller
  Am J Trop Med Hyg. 2007 Jun; 76(6):997-1008
• Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface.
  Alexander G Maier, Melanie Rug, Matthew T O'Neill, James G Beeson, Matthias Marti, John Reeder, Alan F Cowman
  Blood. 2007 Feb; 109(3):1289-1297

2006 (3)

• Development and optimization of high-throughput methods to measure Plasmodium falciparum-specific growth inhibitory antibodies.
  Kristina E M Persson, Chee T Lee, Kevin Marsh, James G Beeson
  J Clin Microbiol. 2006 May; 44(5):1665-1673
• Antigenic differences and conservation among placental Plasmodium falciparum-infected erythrocytes and acquisition of variant-specific and cross-reactive antibodies.
  James G Beeson, Emily J Mann, Timothy J Byrne, Aphrodite Caragounis, Salenna R Elliott, Graham V Brown, Stephen J Rogerson
  J Infect Dis. 2006 Mar; 193(5):721-730
• A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria.
  Till S Voss, Julie Healer, Allison J Marty, Michael F Duffy, Jennifer K Thompson, James G Beeson, John C Reeder, Brendan S Crabb, Alan F Cowman
  Nature. 2006 Feb; 439(7079):1004-1008

2005 (5)

• Promising functional readouts of immunity in a blood-stage malaria vaccine trial.
  Brendan S Crabb, James G Beeson
  PLoS Med. 2005 Nov; 2(11):e380
• Targets of protective antibodies to malaria during pregnancy.
  James G Beeson, Stephen J Rogerson, Salenna R Elliott, Michael F Duffy
  J Infect Dis. 2005 Nov; 192(9):1647-1650
• Placental malaria induces variant-specific antibodies of the cytophilic subtypes immunoglobulin G1 (IgG1) and IgG3 that correlate with adhesion inhibitory activity.
  Salenna R Elliott, Amy K Brennan, James G Beeson, Eyob Tadesse, Malcolm E Molyneux, Graham V Brown, Stephen J Rogerson
  Infect Immun. 2005 Sep; 73(9):5903-5907
• Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected erythrocytes are associated with transcription of var2csa.
  Salenna R Elliott, Michael F Duffy, Timothy J Byrne, James G Beeson, Emily J Mann, Danny W Wilson, Stephen J Rogerson, Graham V Brown
  Infect Immun. 2005 May; 73(5):2848-2856
• Broad analysis reveals a consistent pattern of var gene transcription in Plasmodium falciparum repeatedly selected for a defined adhesion phenotype.
  Michael F Duffy, Timothy J Byrne, Salenna R Elliott, Danny W Wilson, Stephen J Rogerson, James G Beeson, Rintis Noviyanti, Graham V Brown
  Mol Microbiol. 2005 May; 56(3):774-788

2004 (6)

• Clinical features and pathogenesis of severe malaria.
  Claire L Mackintosh, James G Beeson, Kevin Marsh
  Trends Parasitol. 2004 Dec; 20(12):597-603
• Malaria in pregnancy and the endemicity spectrum: what can we learn?
  Francois Nosten, Stephen J Rogerson, James G Beeson, Rose McGready, Theonest K Mutabingwa, Bernard Brabin
  Trends Parasitol. 2004 Sep; 20(9):425-432
• Impairment of humoral immunity to Plasmodium falciparum malaria in pregnancy by HIV infection.
  Adele M Mount, Victor Mwapasa, Salenna R Elliott, James G Beeson, Eyob Tadesse, Valentino M Lema, Malcolm E Molyneux, Steven R Meshnick, Stephen J Rogerson
  Lancet. 2004 Jun; 363(9424):1860-1867
• Phenotypes of Plasmodium falciparum from the peripheral blood of pregnant women.
  James G Beeson, Stephen J Rogerson
  Infect Immun. 2004 Mar; 72(3):1841
• Antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes and adhesion inhibitory antibodies are associated with placental malaria and have overlapping and distinct targets.
  James G Beeson, Emily J Mann, Salenna R Elliott, Valentino M Lema, Eyob Tadesse, Malcolm E Molyneux, Graham V Brown, Stephen J Rogerson
  J Infect Dis. 2004 Feb; 189(3):540-551
• Plasmodium falciparum-infected erythrocytes demonstrate dual specificity for adhesion to hyaluronic acid and chondroitin sulfate A and have distinct adhesive properties.
  James G Beeson, Graham V Brown
  J Infect Dis. 2004 Jan; 189(2):169-179

2002 (4)

• Selective accumulation of mature asexual stages of Plasmodium falciparum-infected erythrocytes in the placenta.
  James G Beeson, Nishal Amin, Maxwell Kanjala, Stephen J Rogerson
  Infect Immun. 2002 Oct; 70(10):5412-5415
• Evaluating specific adhesion of Plasmodium falciparum-infected erythrocytes to immobilised hyaluronic acid with comparison to binding of mammalian cells.
  James G Beeson, Stephen J Rogerson, Graham V Brown
  Int J Parasitol. 2002 Sep; 32(10):1245-1252
• The structural motif in chondroitin sulfate for adhesion of Plasmodium falciparum-infected erythrocytes comprises disaccharide units of 4-O-sulfated and non-sulfated N-acetylgalactosamine linked to glucuronic acid.
  Wengang Chai, James G Beeson, Alexander M Lawson
  J Biol Chem. 2002 Jun; 277(25):22438-22446
• Expanding the paradigms of placental malaria.
  James G Beeson, Brian M Cooke, J Alexandra Rowe, Stephen J Rogerson
  Trends Parasitol. 2002 Apr; 18(4):145-147

2001 (4)

• Parasite adhesion and immune evasion in placental malaria.
  J G Beeson, J C Reeder, S J Rogerson, G V Brown
  Trends Parasitol. 2001 Jul; 17(7):331-337
• Sticky rings: challenging the cytoadherence dogma.
  B M Cooke, J G Beeson, S J Rogerson
  Trends Parasitol. 2001 Feb; 17(2):61
• New agents to combat malaria.
  J G Beeson, P A Winstanley, G I McFadden, G V Brown
  Nat Med. 2001 Feb; 7(2):149-150
• Inhibition of adhesion of Plasmodium falciparum-infected erythrocytes by structurally defined hyaluronic acid dodecasaccharides.
  W Chai, J G Beeson, H Kogelberg, G V Brown, A M Lawson
  Infect Immun. 2001 Jan; 69(1):420-425

2000 (3)

• Identification of glycosaminoglycan binding domains in Plasmodium falciparum erythrocyte membrane protein 1 of a chondroitin sulfate A-adherent parasite.
  J C Reeder, A N Hodder, J G Beeson, G V Brown
  Infect Immun. 2000 Jul; 68(7):3923-3926
• Plasmodium falciparum rosette formation is uncommon in isolates from pregnant women.
  S J Rogerson, J G Beeson, C G Mhango, F K Dzinjalamala, M E Molyneux
  Infect Immun. 2000 Jan; 68(1):391-393
• Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria.
  J G Beeson, S J Rogerson, B M Cooke, J C Reeder, W Chai, A M Lawson, M E Molyneux, G V Brown
  Nat Med. 2000 Jan; 6(1):86-90

1999 (3)

• The placenta in malaria: mechanisms of infection, disease and foetal morbidity.
  S J Rogerson, J G Beeson
  Ann Trop Med Parasitol. 1999 Dec; 93 Suppl 1:S35-S42
• Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic properties.
  J G Beeson, G V Brown, M E Molyneux, C Mhango, F Dzinjalamala, S J Rogerson
  J Infect Dis. 1999 Aug; 180(2):464-472
• The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1.
  J C Reeder, A F Cowman, K M Davern, J G Beeson, J K Thompson, S J Rogerson, G V Brown
  Proc Natl Acad Sci U S A. 1999 Apr; 96(9):5198-5202

News Articles (79)

2019 (1)

• The path to an effective malaria vaccine

2018 (19)

• Cosmos' insights into stunting
• Major milestone for Healthy Mothers, Healthy Babies
• HMHB researcher wins award
• Focus on malaria immunity
• Solutions for maternal mortality
• Malaria elimination to be stepped up, and fast
• Using malaria eradication to boost health security
• 1st Malaria World Congress opens
• Working to beat malaria drug resistance
• Malaria Dialogues: Join the discussion
• Map-building workshop is streets ahead
• Baby Tessie lost her mum post-childbirth
• Burnet research opens new malaria vaccine pathway
• Global Health Security: Why Malaria Elimination is a Priority
• Healthy Mothers, Healthy Babies: On the road with Kerryanne Tokmun
• Optimism on World Malaria Day
• More R&D needed in maternal and newborn health
• Bill Gates calls for Australia to lead fight against malaria
• Vaccine hope as Burnet research unlocks malaria secrets

2017 (10)

• Burnet excels in NHMRC funding
• Key partnership to improve health for Papua New Guineans
• Leading roles for Burnet in NHMRC Malaria CRE
• New insights into malaria immunity
• Lead roles for Burnet malaria researchers
• Burnet research at World Congress on Public Health
• Immunity's key role in emergence of drug-resistant malaria
• Malaria link to low birth weight babies identified
• Precious HMHB samples make pre-Christmas dash to Melbourne
• Burnet Institute and GeoVax join forces to develop malaria vaccine

2016 (9)

• Burnet tall poppy scoops three honours
• HMHB a healthcare innovator
• New tests expand malaria vaccine horizons
• Zika impact may be hidden: study
• This Mother's Day spare a thought for mums in PNG
• From heartbreak to hope: A personal insight from Kokopo
• The quest for a malaria vaccine
• HMHB attracts Principal Supporter
• Mefloquine under scrutiny

2015 (18)

• 2015 in Review: July - December
• MRDC supporting HMHB program
• Fenner Award for Professor James Beeson
• Research award acknowledges team effort
• Achieving malaria elimination: the challenges ahead
• Next step for world's first malaria vaccine
• AMREP Prize for Burnet research
• NHMRC Award for Burnet researchers
• Burnet takes malaria tests to new frontiers
• New measure for malaria exposure
• Malaria elimination demands multiple targets
• Burnet research identifies malaria predator
• New insights into immune system attack on malaria
• Healthy Mothers, Healthy Babies lab officially opened in Kokopo
• This Mother's Day spare a thought for mums and their babies in PNG
• Help us fit out Kokopo lab
• Discovery of malaria-blocking immune response opens door for vaccine
• Dame Carol Kidu Patron for HMHB

2014 (10)

• 2014 in Review: January - June
• 2014 In Review: July - December
• Burnet researchers uncover proteins crucial for effective malaria vaccines
• Burnet collaborator wins top science award
• Study advances understanding of malaria immunity
• Collaboration will advance malaria vaccine development
• World's leading vaccine experts in Melbourne
• ABC News 24 features Burnet's malaria work
• Global burden of vector-borne diseases the focus of World Health Day 2014
• Burnet researchers reveal weakness in malaria's coat

2013 (2)

• Eliminating malaria: vaccines, treatment and prevention.
• Children help researchers solve malaria vaccine puzzle

2012 (9)

• Discovery may lead to pregnancy-specific malaria vaccine
• Research support a key weapon in fight against malaria drug resistance
• Burnet NHMRC grants announcement
• Lifting malaria's deadly veil: mystery solved in quest for vaccine
• Appeal - just $50,000 from reaching our target
• Burnet Institute receives Gates Foundation Grant
• The 'missing pieces' of malaria research
• Malaria caused thousands of ANZAC deaths
• Combination drug treatment can cut malaria by 30 per cent

2011 (1)

• Dr James Beeson joins Burnet Institute