Background
Linda completed her PhD in 2005 at the Institute for Tropical Medicine in Hamburg, Germany, investigating the role of heat shock proteins in Leishmania infections.
She then joined Professor James Beeson’s lab at the Walter and Eliza Hall Institute for Medical Research as a postdoctoral scientist before moving to the Burnet Institute in 2011 with the rest of the group.
Her work is focused on the role of invasion ligands and surface antigens of merozoites as targets of protective antibodies in acquired immunity against both Plasmodium falciparum and Plasmodium vivax malaria. Recent projects have focused on investigating the role of complement-activating antibodies in protective immunity and the identification of correlates of protection to inform vaccine development. She is also involved in projects aiming at identifying targets of functional antibodies against transmission-stage parasites that can interrupt the transmission to the mosquito vector or the subsequent development in the mosquito.
Appointments
- 2021: Honorary Fellow, Department of Medicine, University of Melbourne
- 2020: Adjunct Senior Research Fellow, Department of Immunology, Monash University
- 2018: Postdoctoral Fellow, Australian Centre for Research Excellence in Malaria Elimination
Positions
- 2011: Senior Research Scientist, Burnet Institute
- 2005: Postdoctoral Scientist, Walter and Eliza Hall Institute
Qualifications
- 2005: PhD, University of Hamburg, Bernhard Nocht Institute for Tropical Medicine
Projects (3)
Current (3)
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Developing vaccines against malaria
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Discovering the mechanisms and targets of immunity against malaria
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Serological surveillance to identify mosquito exposure and malaria transmission
Publications (38)
2021 (2)
- Reduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women.
Opi DH, Boyle MJ, McLean ARD, Reiling L, Chan JA, Stanisic DI, Ura A, Mueller I, Fowkes FJI, Rogerson SJ, Beeson JG
BMC Med. 2021 Aug; 19(1):201
- Novel Virus-Like Particle Vaccine Encoding the Circumsporozoite Protein of Plasmodium falciparum Is Immunogenic and Induces Functional Antibody Responses in Mice.
Kurtovic L, Wetzel D, Reiling L, Drew DR, Palmer C, Kouskousis B, Hanssen E, Wines BD, Hogarth PM, Suckow M, Jenzelewski V, Piontek M, Chan JA, Beeson JG
Front Immunol. 2021 Mar; 12:641421
2020 (1)
2019 (10)
- Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity.
Chan JA, Wetzel D, Reiling L, Miura K, Drew DR, Gilson PR, Anderson DA, Richards JS, Long CA, Suckow M, Jenzelewski V, Tsuboi T, Boyle MJ, Piontek M, Beeson JG
PLoS One. 2019 Sep; 14(9):e0221733
- Display of malaria transmission-blocking antigens on chimeric duck hepatitis B virus-derived virus-like particles produced in Hansenula polymorpha.
Wetzel D, Chan JA, Suckow M, Barbian A, Weniger M, Jenzelewski V, Reiling L, Richards JS, Anderson DA, Kouskousis B, Palmer C, Hanssen E, Schembecker G, Merz J, Beeson JG, Piontek M
PLoS One. 2019 Sep; 14(9):e0221394
- IgM in human immunity to Plasmodium falciparum malaria.
Boyle MJ, Chan JA, Handayuni I, Reiling L, Feng G, Hilton A, Kurtovic L, Oyong D, Piera KA, Barber BE, William T, Eisen DP, Minigo G, Langer C, Drew DR, de Labastida Rivera F, Amante FH, Williams TN, Kinyanjui S, Marsh K, Doolan DL, Engwerda C, Fowkes FJI, Grigg MJ, Mueller I, McCarthy JS, Anstey NM, Beeson JG
Sci Adv. 2019 Sep; 5(9):eaax4489
- The contribution of functional antimalarial immunity to measures of parasite clearance in therapeutic efficacy studies of artemisinin derivatives.
O'Flaherty K, Ataíde R, Zaloumis SG, Ashley EA, Powell R, Feng G, Reiling L, Dondorp AM, Day NP, Dhorda M, Fairhurst RM, Lim P, Amaratunga C, Pukrittayakamee S, Hien TT, Htut Y, Mayxay M, Faiz MA, Beeson JG, Nosten F, Simpson JA, White NJ, Fowkes FJI
J Infect Dis. 2019 Aug; 220(7):1178-1187
- Differential Patterns of IgG Subclass Responses to Plasmodium falciparum Antigens in Relation to Malaria Protection and RTS,S Vaccination.
Dobaño C, Santano R, Vidal M, Jiménez A, Jairoce C, Ubillos I, Dosoo D, Aguilar R, Williams NA, Díez-Padrisa N, Ayestaran A, Valim C, Asante KP, Owusu-Agyei S, Lanar D, Chauhan V, Chitnis C, Dutta S, Angov E, Gamain B, Coppel RL, Beeson JG, Reiling L, Gaur D, Cavanagh D, Gyan B, Nhabomba AJ, Campo JJ, Moncunill G
Front Immunol. 2019 Mar; 10:439
- Targets of complement-fixing antibodies in protective immunity against malaria in children.
Reiling L, Boyle MJ, White MT, Wilson DW, Feng G, Weaver R, Opi DH, Persson KEM, Richards JS, Siba PM, Fowkes FJI, Takashima E, Tsuboi T, Mueller I, Beeson JG
Nat Commun. 2019 Feb; 10(1):610
- Antibody Responses to Antigenic Targets of Recent Exposure Are Associated With Low-Density Parasitemia in Controlled Human Plasmodium falciparum Infections.
van den Hoogen LL, Walk J, Oulton T, Reuling IJ, Reiling L, Beeson JG, Coppel RL, Singh SK, Draper SJ, Bousema T, Drakeley C, Sauerwein R, Tetteh KKA
Front Microbiol. 2019 Jan; 9:3300
- Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria.
Chan JA, Drew DR, Reiling L, Lisboa-Pinto A, Dinko B, Sutherland CJ, Dent AE, Chelimo K, Kazura JW, Boyle MJ, Beeson JG
Front Immunol. 2019 Jan; 9:3126
- Challenges and strategies for developing efficacious and long-lasting malaria vaccines.
Beeson JG, Kurtovic L, Dobaño C, Opi DH, Chan JA, Feng G, Good MF, Reiling L, Boyle MJ
Sci Transl Med. 2019 Jan; 11(474):eaau1458
- Antibody Targets on the Surface of Plasmodium falciparum-Infected Erythrocytes That Are Associated With Immunity to Severe Malaria in Young Children.
Chan JA, Boyle MJ, Moore KA, Reiling L, Lin Z, Hasang W, Avril M, Manning L, Mueller I, Laman M, Davis T, Smith JD, Rogerson SJ, Simpson JA, Fowkes FJI, Beeson JG
J Infect Dis. 2019 Jan; 219(5):819-828.
2018 (4)
- Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial.
Jagannathan P, Kakuru A, Okiring J, Muhindo MK, Natureeba P, Nakalembe M, Opira B, Olwoch P, Nankya F, Ssewanyana I, Tetteh K, Drakeley C, Beeson J, Reiling L, Clark TD, Rodriguez-Barraquer I, Greenhouse B, Wallender E, Aweeka F, Prahl M, Charlebois ED, Feeney ME, Havlir DV, Kamya MR, Dorsey G
PLoS Med. 2018 Jul; 15(7):e1002606
- Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children.
Kurtovic L, Behet MC, Feng G, Reiling L, Chelimo K, Dent AE, Mueller I, Kazura JW, Sauerwein RW, Fowkes FJI, Beeson JG
BMC Med. 2018 Apr; 16(1):61
- Human immunization with a polymorphic malaria vaccine candidate induced antibodies to conserved epitopes that promote functional antibodies to multiple parasite strains.
Feng G, Boyle MJ, Cross N, Chan JA, Reiling L, Osier F, Stanisic D, Mueller I, Anders RF, McCarthy JS, Richards JS, Beeson JG
J Infect Dis. 2018 Mar; 218(1):35-43
- Identifying Immune Correlates of Protection Against Plasmodium falciparum Through a Novel Approach to Account for Heterogeneity in Malaria Exposure.
Valmaseda A, Macete E, Nhabomba A, Guinovart C, Aide P, Bardají A, Bassat Q, Nhampossa T, Maculuve S, Casellas A, Quintó L, Sanz S, Jiménez A, Feng G, Langer C, Reiling L, Reddy KS, Pandey A, Chitnis CE, Chauhan VS, Aguilar R, Aponte JJ, Dobaño C, Beeson JG, Gaur D, Menéndez C, Alonso PL, Mayor A
Clin Infect Dis. 2018 Feb; 66(4):586-593
2017 (3)
- Acquisition, maintenance and adaptation of invasion inhibitory antibodies against Plasmodium falciparum invasion ligands involved in immune evasion.
Tijani MK, Babalola OA, Odaibo AB, Anumudu CI, Asinobi AO, Morenikeji OA, Asuzu MC, Langer C, Reiling L, Beeson JG, Wahlgren M, Nwuba RI, Persson KEM
PLoS One. 2017 Aug; 12(8):e0182187
- Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.
McCallum FJ, Persson KM, Fowkes FJ, Reiling L, Mugyenyi CK, Richards JS, Simpson JA, Williams TN, Gilson PR, Hodder AN, Sanders PR, Anders RF, Narum DL, Chitnis C, Crabb BS, Marsh K, Beeson JG.
J Leukoc Biol. 2017 Apr; 101(4):913-925
- Recent insights into humoral immunity targeting Plasmodium falciparum and Plasmodium vivax malaria.
Boyle MJ, Reiling L, Osier FH, Fowkes FJ
Int J Parasitol. 2017 Jan; 47(2-3):99-104
2016 (2)
- Evaluating complement-mediated humoral immunity to P. falciparum blood stages.
Boyle MJ, Reiling L, Beeson JG
eBiomedicine. 2016 Dec; 14:9-10
- The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria.
Weaver R, Reiling L, Feng G, Drew DR, Mueller I, Siba PM, Tsuboi T, Richards JS, Fowkes FJ, Beeson JG
Sci Rep. 2016 Sep; 6:33094
2015 (1)
- Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria.
Boyle MJ, Reiling L, Feng GQ, Langer C, Osier FH, Aspeling-Jones H, Cheng YS, Stubbs J, Tetteh KKA, Conway DJ, McCarthy JS, Muller I, Marsh K, Anders RF, Beeson JG
Immunity. 2015 Mar; 42(3):580-590
2014 (4)
- Subclass responses and their half-lives for antibodies against EBA175 and PfRh2 in naturally acquired immunity against Plasmodium falciparum malaria.
Ahmed Ismail H, Tijani MK, Langer C, Reiling L, White MT, Beeson JG, Wahlgren M, Nwuba R, Persson KE
Malar J. 2014 Nov; 13(1):425
- Research priorities for the development and implementation of serological tools for malaria surveillance
Elliott SR, Fowkes FJI, Richards JS, Reiling L, Drew DR, Beeson JG
F1000Prime Reports. 2014 Nov; 6:100
- Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria.
Osier FH, Feng G, Boyle MJ, Langer C, Zhou J, Richards JS, McCallum FJ, Reiling L, Jaworowski A, Anders RF, Marsh K, Beeson JG
BMC Med. 2014 Jul; 12(1):108
- Correlates of protection for Plasmodium falciparum malaria vaccine development: current knowledge and future research (Book Chapter)
Beeson JG, Fowkes FJI, Reiling L, Osier FH, Drew DR, Brown GV
Malaria Vaccine Development: Over 40 Years of Trials and Tribulations. 2014 Apr; Chapter 6:81-104
2013 (3)
- Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.
Richards JS, Arumugam TU, Reiling L, Healer J, Hodder AN, Fowkes FJ, Cross N, Langer C, Takeo S, Uboldi AD, Thompson JK, Gilson PR, Coppel RL, Siba PM, King CL, Torii M, Chitnis CE, Narum DL, Mueller I, Crabb BS, Cowman AF, Tsuboi T, Beeson JG
J Immunol. 2013 Jun; 191(2):795-809
- Erythrocyte-Binding Antigens of Plasmodium falciparum Are Targets of Human Inhibitory Antibodies and Function To Evade Naturally Acquired Immunity.
Persson KE, Fowkes FJ, McCallum FJ, Gicheru N, Reiling L, Richards JS, Wilson DW, Lopaticki S, Cowman AF, Marsh K, Beeson JG
J Immunol. 2013 Jun; 191(2):785-794
- Acquired antibodies to merozoite antigens in children from Uganda with uncomplicated or severe Plasmodium falciparum malaria.
Ahmed Ismail H, Ribacke U, Reiling L, Normark J, Egwang T, Kironde F, Beeson JG, Wahlgren M, Persson KE
Clin Vaccine Immunol. 2013 Jun; 20(8):1170-1180
2012 (3)
- The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria.
Reiling L, Richards JS, Fowkes FJ, Wilson DW, Chokejindachai W, Barry AE, Tham WH, Stubbs J, Langer C, Donelson J, Michon P, Tavul L, Crabb BS, Siba PM, Cowman AF, Mueller I, Beeson JG
PLoS One. 2012 Sep; 7(9):e45253
- Antigenic Characterisation of an Intrinsically Unstructured Protein: Plasmodium falciparum Merozoite Surface Protein 2.
Adda CG, Macraild CA, Reiling L, Wycherley K, Boyle MJ, Kienzle V, Masendycz P, Foley M, Beeson JG, Norton RS, Anders RF
Infect Immun. 2012 Sep; 80(12):4177-4185
- Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity.
Chan JA, Howell KB, Reiling L, Ataide R, Mackintosh CL, Fowkes FJ, Petter M, Chesson JM, Langer C, Warimwe GM, Duffy MF, Rogerson SJ, Bull PC, Cowman AF, Marsh K, Beeson JG
J Clin Invest. 2012 Sep; 122(9):3227-3238
2010 (2)
- Evidence that the erythrocyte invasion ligand PfRh2 is a target of protective immunity against Plasmodium falciparum malaria.
Reiling L, Richards JS, Fowkes FJ, Barry AE, Triglia T, Chokejindachai W, Michon P, Tavul L, Siba PM, Cowman AF, Mueller I, Beeson JG
J Immunol. 2010 Nov; 185(10):6157-6167
- Overexpression of a single Leishmania major gene enhances parasite infectivity in vivo and in vitro.
Reiling L, Chrobak M, Schmetz C, Clos J
Mol Microbiol. 2010 Jun; 76(5):1175-1190
2009 (1)
2008 (1)
2006 (1)
News Articles (10)
2020 (1)
2019 (4)
2018 (2)
2014 (1)
2013 (1)
2012 (1)
