Background
Having previously worked in molecular biology orientated laboratories in both Hamburg and Melbourne, Christine is now responsible for the electron microscopy work that is being done within Professor James Beeson’s laboratory.
She uses Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) to answer specific questions about the malaria parasite.
These include understanding cell surface morphology of malaria cell lines, describing interactions between different cell types; showing changes to the morphology of cell compartments in genetic manipulated cell lines or tracking specific antigens with the help of immunolabelling.
Positions
- 2011: Research Assistant, Beeson Laboratory, Burnet Institute, Melbourne, Australia
- 2010-2011: Research Assistant, Beeson Laboratory, Walter and Eliza Hall Institute
- 2007-2010: Research Assistant with Professor Alan Cowman in the Division of Infection and Immunity, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
- 2003-2007: Research Assistant with Professor Tim W. Gilberger, Malaria II at the Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
- 2002-2003: Research Assistant with Professor R.D Walter, Biochemical Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Publications (33)
2020 (1)
- Infectious KoRV-related retroviruses circulating in Australian bats.
Hayward JA, Tachedjian M, Kohl C, Johnson A, Dearnley M, Jesaveluk B, Langer C, Solymosi PD, Hille G, Nitsche A, Sánchez CA, Werner A, Kontos D, Crameri G, Marsh GA, Baker ML, Poumbourios P, Drummer HE, Holmes EC, Wang LF, Smith I, Tachedjian G
Proc Natl Acad Sci U S A. 2020 Apr; 117(7):9529–9536
2019 (1)
- IgM in human immunity to Plasmodium falciparum malaria.
Boyle MJ, Chan JA, Handayuni I, Reiling L, Feng G, Hilton A, Kurtovic L, Oyong D, Piera KA, Barber BE, William T, Eisen DP, Minigo G, Langer C, Drew DR, de Labastida Rivera F, Amante FH, Williams TN, Kinyanjui S, Marsh K, Doolan DL, Engwerda C, Fowkes FJI, Grigg MJ, Mueller I, McCarthy JS, Anstey NM, Beeson JG
Sci Adv. 2019 Sep; 5(9):eaax4489
2018 (3)
- Factors influencing the induction of high affinity antibodies to Plasmodium falciparum merozoite antigens and how affinity changes over time.
Tijani MK, Reddy SB, Langer C, Beeson JG, Wahlgren M, Nwuba RI, Persson KEM
Sci Rep. 2018 Jun; 8(1):9026
- Identifying Immune Correlates of Protection Against Plasmodium falciparum Through a Novel Approach to Account for Heterogeneity in Malaria Exposure.
Valmaseda A, Macete E, Nhabomba A, Guinovart C, Aide P, Bardají A, Bassat Q, Nhampossa T, Maculuve S, Casellas A, Quintó L, Sanz S, Jiménez A, Feng G, Langer C, Reiling L, Reddy KS, Pandey A, Chitnis CE, Chauhan VS, Aguilar R, Aponte JJ, Dobaño C, Beeson JG, Gaur D, Menéndez C, Alonso PL, Mayor A
Clin Infect Dis. 2018 Feb; 66(4):586-593
- Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays.
Hommel M, Chan JA, Umbers AJ, Langer C, Rogerson SJ, Smith JD, Beeson JG
Parasit Vectors. 2018 Jan; 11(1):69
2017 (4)
- Acquisition, maintenance and adaptation of invasion inhibitory antibodies against Plasmodium falciparum invasion ligands involved in immune evasion.
Tijani MK, Babalola OA, Odaibo AB, Anumudu CI, Asinobi AO, Morenikeji OA, Asuzu MC, Langer C, Reiling L, Beeson JG, Wahlgren M, Nwuba RI, Persson KEM
PLoS One. 2017 Aug; 12(8):e0182187
- Dichotomous miR expression and immune responses following primary blood-stage malaria.
Burel JG, Apte SH, Groves PL, Boyle MJ, Langer C, Beeson JG, McCarthy JS, Doolan DL
JCI Insight. 2017 Aug; 2(15)::e93434
- Host age and expression of genes involved in red blood cell invasion in Plasmodium falciparum field isolates.
Valmaseda A, Bassat Q, Aide P, Cisteró P, Jiménez A, Casellas A, Machevo S, Aguilar R, Sigaúque B, Chauhan VS, Langer C, Beeson J, Chitnis C, Alonso PL, Gaur D, Mayor A
Sci Rep. 2017 Jul; 7(1):4717
- Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort.
Ataide R, Ashley EA, Powell R, Chan JA, Malloy MJ, O'Flaherty K, Takashima E, Langer C, Tsuboi T, Dondorp AM, Day NP, Dhorda M, Fairhurst RM, Lim P, Amaratunga C, Pukrittayakamee S, Hien TT, Htut Y, Mayxay M, Faiz MA, Beeson JG, Nosten F, Simpson JA, White NJ, Fowkes FJ
PNAS. 2017 Mar; 114(13):3515-3520
2016 (3)
- Infectivity of Plasmodium falciparum in malaria-naive individuals is related to knob expression and cytoadherence of the parasite.
Stanisic DI, Gerrard J, Fink J, Griffin PM, Liu XQ, Sundac L, Sekuloski S, Rodriguez IB, Pingnet J, Yang Y, Zhou Y, Trenholme KR, Wang CY, Hackett H, Chan JA, Langer C, Hanssen E, Hoffman SL, Beeson JG, McCarthy JS, Good MF
Infect Immun. 2016 Jul; 84(9):2689-2696
- A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies.
Chan JA, Howell KB, Langer C, Maier AG, Hasang W, Rogerson SJ, Petter M, Chesson J, Stanisic DI, Duffy MF, Cooke BM, Siba PM, Mueller I, Bull PC, Marsh K, Fowkes FJ, Beeson JG
Cell Mol Life Sci. 2016 May; 73(21):4141-4158
- Maternal-foetal transfer of Plasmodium falciparum and Plasmodium vivax antibodies in a low transmission setting.
Charnaud SC, McGready R, Herten-Crabb A, Powell R, Guy A, Langer C, Richards JS, Gilson PR, Chotivanich K, Tsuboi T, Narum DL, Pimanpanarak M, Simpson JA, Beeson JG, Nosten F, Fowkes FJ
Sci Rep. 2016 Feb; 6:20859
2015 (3)
- Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.
Wilson DW, Goodman CD, Sleebs BE, Weiss GE, de Jong NW, Angrisano F, Langer C, Baum J, Crabb BS, Gilson PR, McFadden GI, Beeson JG
BMC Biol. 2015 Jul; 13(1):52
- The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial.
Chandrasiri UP, Fowkes FJ, Richards JS, Langer C7, Fan YM, Taylor SM, Beeson JG, Dewey KG, Maleta K, Ashorn P, Rogerson SJ
Malar J. 2015 May; 14(1):193
- Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria.
Boyle MJ, Reiling L, Feng GQ, Langer C, Osier FH, Aspeling-Jones H, Cheng YS, Stubbs J, Tetteh KKA, Conway DJ, McCarthy JS, Muller I, Marsh K, Anders RF, Beeson JG
Immunity. 2015 Mar; 42(3):580-590
2014 (5)
- Export of virulence proteins by malaria-infected erythrocytes involves remodeling of host actin cytoskeleton.
Rug M, Cyrklaff M, Mikkonen A, Lemgruber L, Kuelzer S, Sanchez CP, Thompson J, Hanssen E, O'Neill M, Langer C, Lanzer M, Frischknecht F, Maier AG, Cowman AF
Blood. 2014 Nov; 124(23):3459-3468
- Subclass responses and their half-lives for antibodies against EBA175 and PfRh2 in naturally acquired immunity against Plasmodium falciparum malaria.
Ahmed Ismail H, Tijani MK, Langer C, Reiling L, White MT, Beeson JG, Wahlgren M, Nwuba R, Persson KE
Malar J. 2014 Nov; 13(1):425
- Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria.
Osier FH, Feng G, Boyle MJ, Langer C, Zhou J, Richards JS, McCallum FJ, Reiling L, Jaworowski A, Anders RF, Marsh K, Beeson JG
BMC Med. 2014 Jul; 12(1):108
- Decreasing malaria prevalence and its potential consequences for immunity in pregnant women.
Teo A, Hasang W, Randall LM, Feng G, Bell L, Unger H, Langer C, Beeson JG, Siba PM, Mueller I, Molyneux ME, Brown GV, Rogerson SJ.
J Infect Dis. 2014 May; 210(9):1444-1455
- Sequential processing of merozoite surface proteins during and after erythrocyte invasion by Plasmodium falciparum.
Boyle MJ, Langer C, Chan JA, Hodder AN, Coppel RL, Anders RF, Beeson JG
Infect Immun. 2014 Jan; 82(3):924-936
2013 (2)
- Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.
Richards JS, Arumugam TU, Reiling L, Healer J, Hodder AN, Fowkes FJ, Cross N, Langer C, Takeo S, Uboldi AD, Thompson JK, Gilson PR, Coppel RL, Siba PM, King CL, Torii M, Chitnis CE, Narum DL, Mueller I, Crabb BS, Cowman AF, Tsuboi T, Beeson JG
J Immunol. 2013 Jun; 191(2):795-809
- Defining the timing of action of anti-malarial drugs against Plasmodium falciparum.
Wilson DW, Langer C, Goodman CD, McFadden GI, Beeson JG
Antimicrob Agents Chemother. 2013 Jan; 57(3):1455-1467
2012 (3)
- The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria.
Reiling L, Richards JS, Fowkes FJ, Wilson DW, Chokejindachai W, Barry AE, Tham WH, Stubbs J, Langer C, Donelson J, Michon P, Tavul L, Crabb BS, Siba PM, Cowman AF, Mueller I, Beeson JG
PLoS One. 2012 Sep; 7(9):e45253
- Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity.
Chan JA, Howell KB, Reiling L, Ataide R, Mackintosh CL, Fowkes FJ, Petter M, Chesson JM, Langer C, Warimwe GM, Duffy MF, Rogerson SJ, Bull PC, Cowman AF, Marsh K, Beeson JG
J Clin Invest. 2012 Sep; 122(9):3227-3238
- PfSET10, a Plasmodium falciparum methyltransferase, maintains the active var gene in a poised state during parasite division.
Volz JC, Bártfai R, Petter M, Langer C, Josling GA, Tsuboi T, Schwach F, Baum J, Rayner JC, Stunnenberg HG, Duffy MF, Cowman AF
Cell Host Microbe. 2012 Jan; 11(1):7-18
2010 (1)
2009 (2)
- Identification of rhoptry trafficking determinants and evidence for a novel sorting mechanism in the malaria parasite Plasmodium falciparum.
Richard D, Kats LM, Langer C, Black CG, Mitri K, Boddey JA, Cowman AF, Coppel RL
PLoS Pathog. 2009 Mar; 5(3):e1000328
- Sequence requirements for the export of the Plasmodium falciparum Maurer's clefts protein REX2.
Haase S, Herrmann S, Grüring C, Heiber A, Jansen PW, Langer C, Treeck M, Cabrera A, Bruns C, Struck NS, Kono M, Engelberg K, Ruch U, Stunnenberg HG, Gilberger TW, Spielmann T
Mol Microbiol. 2009 Feb; 71(4):1003-1017
2008 (3)
- Plasmodium falciparum possesses two GRASP proteins that are differentially targeted to the Golgi complex via a higher- and lower-eukaryote-like mechanism.
Struck NS, Herrmann S, Langer C, Krueger A, Foth BJ, Engelberg K, Cabrera AL, Haase S, Treeck M, Marti M, Cowman AF, Spielmann T, Gilberger TW
J Cell Sci. 2008 Jul; 121(Pt 13):2123-2129
- Spatial dissection of the cis- and trans-Golgi compartments in the malaria parasite Plasmodium falciparum.
Struck NS, Herrmann S, Schmuck-Barkmann I, de Souza Dias S, Haase S, Cabrera AL, Treeck M, Bruns C, Langer C, Cowman AF, Marti M, Spielmann T, Gilberger TW
Mol Microbiol. 2008 Mar; 67(6):1320-1330
- Characterization of a conserved rhoptry-associated leucine zipper-like protein in the malaria parasite Plasmodium falciparum.
Haase S, Cabrera A, Langer C, Treeck M, Struck N, Herrmann S, Jansen PW, Bruchhaus I, Bachmann A, Dias S, Cowman AF, Stunnenberg HG, Spielmann T, Gilberger TW
Infect Immun. 2008 Mar; 76(3):879-887
2006 (1)
2005 (1)
News Articles (4)
2020 (1)
2019 (1)
2013 (1)
2012 (1)
