Drug resistance and mechanism of action studies

Drugs are the main weapons used to combat malaria infection, but parasites are becoming resistant and new medicines and drug targets are needed. Through a broad range of biochemical, cell biology and molecular biology methods we are deciphering how different novel antimalarials work. We work with medicinal chemists who improve the potency and specificity of a range of novel and repurposed drugs, to develop new antimalarials that are effective against already multi-drug resistant parasites.

Objective

We seek to repurpose commercial compounds for use against malaria parasites and investigate how parasites become resistant to current antimalarial compounds. 

Timeline

2015–completed.

Approach

We use state-of-the-art genetic modification tools, including CRISPR/Cas9, alongside whole genome sequencing and a range of biochemical and plate-based assays to decipher how antimalarial compounds we have discovered act to kill the parasites.

Community impact

Better, safer, and cheaper antimalarial drugs would benefit endemic communities around the world and could accelerate malaria elimination. The research will also provide new knowledge about parasite biology that could inform future treatment options.