Discovering novel antimalarials to block parasite invasion of human cells

Drugs are the main weapons used to combat malaria infection, but parasites are becoming resistant and new medicines and drug targets are needed. We are developing new antimalarials that prevent the parasite from entering the host red blood cell. If the parasite cannot invade, it cannot cause disease. We use our extensive history in deciphering the invasion process of malaria parasites to inform drug discovery.

Objective 

We seek to better understand how the malaria parasite enters red blood cells, and to use this knowledge to discover and develop novel therapeutics.

Timeline

2003–ongoing.

Approach

We are pioneers in using live cell microscopy to investigate how malaria parasites get into host red blood cells. We use this specialised technique to aid in our discovery of novel antimalarial compounds that inhibit this process.

Community impact

Better, safer and cheaper antimalarial drugs would benefit endemic communities around the world and could accelerate malaria elimination. The research will also provide new knowledge about parasite biology that could inform future treatment options.