How ‘Simply B’ is simplifying hepatitis B treatment

A Burnet Institute study into novel treatments for hepatitis B will benefit from AUD$190,000 in funding from Gilead Sciences’ TREAT HBV international grant program.

Conducted in partnership with St Vincent’s Hospital and community primary healthcare services in Melbourne, the ‘Simply B’ study is piloting a novel e-decision support tool to simplify hepatitis B treatment to enable GPs to treat in the community.

Burnet Senior Research Fellow and Simply B Study Lead, Dr Jess Howell said almost all treatment for hepatitis B in Australia occurs in hospitals, but the rate of treatment to prevent complications of hepatitis B, such as cirrhosis and liver cancer, is low.

“It provides immediate feedback based on clinical parameters and blood tests for GPs to have a treatment decision while they're with the patient, to allow them to either treat or monitor the patient.

“And then it also links to the hospital, so the hospital follows up with the GP within 24 hours to provide the specialist support they require.”

Dr Howell said e-decision support tools are not uncommon, but the difference in this case is how it will significantly simplify the treatment algorithm for GPs.

“We know from previous work we've done that the treatment guidelines are very complicated,” Dr Howell said.

“It's very difficult for GPs to know what to do with hepatitis B patients in the community, so they tend to refer them all into hospital.

“This system provides simplified treatment and a really clear pathway for the GP to either treat, or monitor the patient, backed-up with specialist support.”

A handful of general practices in suburban Melbourne are taking part in the pilot study with support from St Vincent’s Hospital, though Dr Howell believes there’s scope to expand the study nationally and potentially into the Asia-Pacific region.

Hepatitis B is treatable and preventable

Of the more than 250,000 people in Australia living with hepatitis B – which includes a high proportion of Indigenous Australians and people from culturally and linguistically diverse communities – less than 10 percent are on treatment.

Hepatitis B causes significant liver cirrhosis and liver failure, and is a key cause of liver cancer.

Learn more about our Hepatitis B work