Working groups
After completing her Bachelor of Biomedical Science degree in 2006, Hayley went on to pursue her Honours and PhD degrees in the laboratory of Professor Brendan Crabb and Associate Professor Paul Gilson at the Walter and Eliza Hall Institute and later at the Burnet Institute. Her work centred on deciphering the roles of novel membrane protein complexes in the malaria parasite Plasmodium falciparum, specifically the export machinery termed PTEX.
After completing her PhD studies, Hayley moved to the laboratory of Professor Dominique Soldati-Favre at the University of Geneva, Switzerland where she continued her research on model Apicomplexan parasite Toxoplasma gondii. Here she deciphered the signalling mechanisms underpinning a key step in the invasion process of T. gondii.
In late 2015 Hayley moved back to the Burnet Institute in the laboratory of Professor Brendan Crabb and Associate Professor Paul Gilson, whereupon she initiated antimalarial mechanism of action and resistance studies, and investigations into novel aspect of malaria protein export.
ACS Infectious Diseases
Dawson B. Ling, Oliver Looker, Zahra Razook, Kirsty McCann, Alyssa E. Barry, Hayley E. Bullen, Brendan S. Crabb, Paul R. Gilson
PLoS Pathogens
Thorey K. Jonsdottir, Brendan Elsworth, Mikha Gabriela, Ellen Ploeger, Molly Parkyn Schneider, Sarah C. Charnaud, Madeline G. Dans, Hayley E. Bullen, Brendan S. Crabb, Paul R. Gilson
Trends in Parasitology
Fiona Angrisano, Hayley E. Bullen
Drugs are the main weapons used to combat malaria infection. However, parasites are becoming resistant and new medicines and drug targets are needed.
This project aims to understand how novel mutations will affect malaria parasites from West Africa.
Drugs are the main weapons used to combat malaria infection, but parasites are becoming resistant and new medicines and drug targets are needed.
We work with medicinal chemists to develop new antimalarials that are effective against already multi-drug resistant parasites.