Publications & Reports

NF-kappaB subunit specificity in hemopoiesis.

Gerondakis S, Banerjee A, Grigoriadis G, Vasanthakumar A, Gugasyan R, Sidwell T, Grumont RJ
Burnet Institute, Prahran, Vic., Australia. [email protected] and


Although the diverse functions served by the nuclear factor-kappaB (NF-kappaB) pathway in virtually all cell types are typically employed to deal with stress responses, NF-kappaB transcription factors also play key roles in the development of hemopoietic cells. This review focuses on how NF-kappaB transcription factors control various aspects of thymic T-cell and myeloid cell differentiation that include its roles in hemopoietic precursors, conventional alphabeta T cells, CD4(+) regulatory T cells, natural killer T cells, gammadelta T cells, macrophages, and dendritic cells.


  • Journal: Immunological Reviews
  • Published: 01/03/2012
  • Volume: 246
  • Issue: 1
  • Pagination: 272-285