Publications & Reports

The role of naive T-cells in HIV-1 pathogenesis: an emerging key player.

Khoury G, Rajasuriar R, Cameron PU, Lewin SR
Department of Medicine, Monash University, Melbourne Victoria, 3004, Australia.

Abstract

Functional naive T-cells are critical for an effective immune response to multiple pathogens.

HIV leads to a significant reduction in CD4+ naive T-cell number and impaired function and there is incomplete recovery following combination antiretroviral therapy (cART).

Here we review the basic homeostatic mechanisms that maintain naive CD4+ T-cells and discuss recent developments in understanding the impact of HIV infection on naive CD4+ T-cells.

Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of naive CD4+ T-cells.

Publication

  • Journal: Clinical Immunology
  • Published: 01/12/2011
  • Volume: 141
  • Issue: 3
  • Pagination: 253-267

Health Issue

Download