Publications & Reports

Non-canonical peptides bound to MHC.

Day SL, Ramsland PA, Apostolopoulos V
Macfarlane Burnet Institute for Medical Research, Centre for Immunology, Immunology and Vaccine, and Structural Immunology Laboratories, VIC, Australia.

Abstract

Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic peptide. T cell receptors (TCR) have programmed specificity for particular peptide/MHC complexes, which ensures focused immune responses are generated against the antigen source. To design effective peptide based vaccines a comprehensive understanding of the specific interactions between MHC molecules and peptide, and of TCR recognition of MHC/peptide is valuable. We place particular emphasis on non-canonical bound peptides and their use in immunotherapy studies.

Publication

  • Journal: Current Pharmaceutical Design
  • Published: 28/10/2009
  • Volume: 15
  • Issue: 28
  • Pagination: 3274-3282