Publications & Reports

To Include or Occlude: Rational Engineering of HCV Vaccines for Humoral Immunity.

Schlotthauer F, McGregor J, Drummer HE
Viral Entry and Vaccines Group, Burnet Institute, Melbourne, VIC 3004, Australia.


Direct-acting antiviral agents have proven highly effective at treating existing hepatitis C infections but despite their availability most countries will not reach the World Health Organization targets for elimination of HCV by 2030. A prophylactic vaccine remains a high priority. Whilst early vaccines focused largely on generating T cell immunity, attention is now aimed at vaccines that generate humoral immunity, either alone or in combination with T cell-based vaccines. High-resolution structures of hepatitis C viral glycoproteins and their interaction with monoclonal antibodies isolated from both cleared and chronically infected people, together with advances in vaccine technologies, provide new avenues for vaccine development.

Link to publisher’s web site


  • Journal: Viruses
  • Published: 30/04/2021
  • Volume: 13
  • Issue: 5
  • Pagination: 805