Publications & Reports

The Ins and Outs of Plasmodium Rhoptries, Focusing on the Cytosolic Side.

Liffner B, Balbin JM, Wichers JS, Gilberger TW, Wilson DW
Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia.


Parasites of the genus Plasmodium cause human and animal malaria, leading to significant health and economic impacts. A key aspect of the complex life cycle of Plasmodium parasites is the invasion of the parasite into its host cell, which is mediated by secretory organelles. The largest of these organelles, the rhoptry, undergoes rapid and profound physiological changes when it secretes its contents during merozoite and sporozoite invasion of the host erythrocyte and hepatocyte, respectively. Here we discuss recent advancements in our understanding of the dynamic rhoptry biology during the parasite’s invasive stages, with a focus on the roles of cytosolically exposed rhoptry-interacting proteins (C-RIPs). We explore potential similarities between the molecular mechanisms driving merozoite and sporozoite rhoptry function.

Link to publisher’s web side


  • Journal: Trends in Parasitology
  • Published: 30/04/2021
  • Volume: 37
  • Issue: 7
  • Pagination: 638-650