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FcgammaRs have been the focus of extensive research due to their key role linking innate and humoral immunity and their implication in both inflammatory and infectious disease. Within the human FcgammaR family FcgammaRII (activatory FcgammaRIIa and FcgammaRIIc, and inhibitory FcgammaRIIb) are unique in their ability to signal independent of the common gamma chain. Through improved understanding of the structure of these receptors and how this affects their function we may be able to better understand how to target FcgammaR specific immune activation or inhibition, which will facilitate in the development of therapeutic monoclonal antibodies in patients where FcgammaRII activity may be desirable for efficacy. This review is focused on roles of the human FcgammaRII family members and their link to immunoregulation in healthy individuals and infection, autoimmunity and cancer.
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