Publications & Reports

Maternal clinical predictors of preterm birth in twin pregnancies: A systematic review involving 2,930,958 twin pregnancies.

Marleen S, Hettiarachchi J, Dandeniya R, Macgreggor R, Aquilina J, Khalil A, Vogel J, Betrán AP, Thangaratinam S

Abstract

In twin pregnancies, which are at high risk of preterm birth, it is not known if maternal clinical characteristics pose additional risks. We undertook a systematic review to assess the risk of both spontaneous and iatrogenic early ( 35 (OR 1.63, 95% CI 1.30-2.05, I(2) = 52%), nulliparous (OR 1.51, 95% CI 1.38-1.65, I(2) = 73%), non-white vs. white (OR 1.31, 95% CI 1.20-1.43, I(2) = 0%), black vs. non-black (OR 1.38, 95% CI 1.07-1.77, I(2) = 98%), diabetes (OR 1.73, 95% CI 1.29-2.33, I(2) = 0%) and smokers (OR 1.30, 95% CI 1.23-1.37, I(2) = 0%). The odds of late preterm birth were also increased in women with history of preterm birth (OR 3.08, 95% CI 2.10-4.51, I(2) = 73%), teenagers (OR 1.36, 95% CI 1.18-1.57, I(2) = 57%), BMI > 35 (OR 1.18, 95% CI 1.02-1.35, I(2) = 46%), nulliparous (OR 1.41, 95% CI 1.23-1.62, I(2) = 68%), diabetes (OR 1.44, 95% CI 1.05-1.98, I(2) = 55%) and hypertension (OR 1.49, CI 1.20-1.86, I(2) = 52%). The additional risks posed by maternal clinical characteristics for early and late preterm birth should be taken into account while counseling and managing women with twin pregnancies.

Link to publisher’s web site

Publication

  • Journal: European Journal of Obstetrics, Gynecology, and Reproductive Biology
  • Published: 01/11/2018
  • Volume: 230
  • Pagination: 159-171

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