Publications & Reports

Association of haptoglobin levels with age, parasite density, and haptoglobin genotype in a malaria-endemic area of Gabon.

Freya J I Fowkes, Heather Imrie, Florence Migot-Nabias, Pascal Michon, Anita Justice, Phillipe Deloron, Adrian J F Luty, Karen P Day
Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom. freya.fowkes@med.nyu.edu

Abstract

Haptoglobin (Hp) levels were investigated in relation to host genotype in a malaria-endemic area in Gabon. A cross-sectional study of 1-12-year-old children was conducted in the rainy season, a period of high malaria transmission, to examine this relationship. Variables that influenced Hp levels were Hp genotype, location, and age interacting with parasite density. At low parasite densities, there was a negative correlation between Hp levels and age. At higher densities, there was a positive correlation with age. This suggests that in the presence of greater parasite-induced hemolysis, older children are capable of increased production of Hp. Sickle cell trait and ABO blood group was not associated with Hp levels in this population.

Publication

  • Journal: The American journal of tropical medicine and hygiene
  • Published: 01/01/2006
  • Volume: 74
  • Issue: 1
  • Pagination: 26-30

Author

Health Issue