Publications & Reports

Linkage and retention in HCV care for HIV-infected populations: early data from the DAA era.

Sacks-Davis R, Doyle JS, Rauch A, Beguelin C, Pedrana AE, Matthews GV, Prins M, van der Valk M, Klein MB, Saeed S, Lacombe K, Chkhartishvili N, Altice FL, Hellard ME
Disease Elimination Program, Burnet Institute, Melbourne, Australia.

Abstract

INTRODUCTION: There is currently no published data on the effectiveness of DAA treatment for elimination of HCV infection in HIV-infected populations at a population level. However, a number of relevant studies and initiatives are emerging. This research aims to report cascade of care data for emerging HCV elimination initiatives and studies that are currently being evaluated in HIV/HCV co-infected populations in the context of implementation science theory. METHODS: HCV elimination initiatives and studies in HIV co-infected populations that are currently underway were identified. Context, intervention characteristics and cascade of care data were synthesized in the context of implementation science frameworks. RESULTS: Seven HCV elimination initiatives and studies were identified in HIV co-infected populations, mainly operating in high-income countries. Four were focused mainly on HCV elimination in HIV-infected gay and bisexual men (GBM), and three included a combination of people who inject drugs (PWID), GBM and other HIV-infected populations. None were evaluating treatment delivery in incarcerated populations. Overall, HCV RNA was detected in 4894 HIV-infected participants (range within studies: 297 to 994): 48% of these initiated HCV treatment (range: 21% to 85%; within studies from a period where DAAs were broadly available the total is 57%, range: 36% to 74%). Among studies with treatment completion data, 96% of 1109 initiating treatment completed treatment (range: 94% to 99%). Among those who could be assessed for sustained virological response at 12 weeks (SVR12), 1631 of 1757 attained SVR12 (93%, range: 86% to 98%). CONCLUSIONS: Early results from emerging research on HCV elimination in HIV-infected populations suggest that HCV treatment uptake is higher than reported levels prior to DAA treatment availability, but approximately half of patients remain untreated. These results are among diagnosed populations and additional effort is required to increase diagnosis rates. Among those who have initiated treatment, completion and SVR rates are promising. More data are required in order to evaluate the effectiveness of these elimination programmes in the long term, assess which intervention components are effective, and whether they need to be tailored to particular population groups.

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Co-EC is funded by BMS. HCVree is funded by MSD. The Swiss HIV Cohort study is funded by the Swiss National Science Foundation (grant no. 148522), and by the SHCS Research Foundation. CEASE is funded by Gilead Sciences and BMS. MC Free is funded by Abbvie, Gilead Sciences, Johnson & Johnson, Merck Sharp & Dohme, and Roche. The Canadian Co-infection Cohort Study is funded by the Canadian Institutes of Health Research (CIHR; FDN-143270), the CIHR Canadian HIV Trials Network (CTN-222) and the Fonds de recherche Quebec- Sante, Reseau SIDA/maladies infectieuses (FRQ-S). Georgian AIDSHIS is co-funded by the Georgian national HIV/AIDS Management Program and the Global Fund to Fight AIDS, Tuberculosis and Malaria. ANRS CO13 HEPAVIH is funded by the French National Agency for Research on AIDS and Viral Hepatitis (ANRS) and also receives funding from Roche, Schering-Plough, GSK, BMS, and Merck-Serono. RSD is supported by an Early Career Fellowship from the Australian National Health and Medical Research Council. JD is supported by a Clinical Fellowship from the Australian National Health and Medical Research Council. MBK is supported by a Chercheur National career award from the FRQ-S. MH is supported by a Principal Research Fellowship from the Australian National Health and Medical Research Council. The Burnet Institute is supported by the Victorian Operational Infrastructure Support Program

Publication

  • Journal: Journal of the International AIDS Society
  • Published: 01/04/2018
  • Volume: 21 Suppl 2
  • Pagination: e25051

Authors

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