Publications & Reports

Analysis of a previously identified 'pain protective' haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: a genetic association study.

Wadley AL, Lombard Z, Cherry CL, Price P, Kamerman PR
Brain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, Division of Human Genetics, School of Pathology, , National Health Laboratory Service and University of the Witwatersrand, Johannesburg, Center for Virolog


We analysed GCH1 in symptomatic HIV-associated sensory neuropathy (HIV-SN) in Southern Africans including a ‘pain protective’ 3-SNP haplotype and 6 SNPs, analysed individually and in a 6-SNP haplotype. The ‘pain protective’ 3-SNP haplotype and a 6-SNP haplotype containing these alleles associated with a reduced risk of pain. Another 3-SNP haplotype associated with increased presence of pain. Associations were lost after correction for age, gender and CD4 T-cell count. Linkage disequilibrium differed between our cohort and Caucasians suggesting that these SNPs may not be ideal markers in Africans. Subsequently the role of GCH1 in painful HIV-SN remains possible.



  • Journal: Journal of Acquired Immune Deficiency Syndromes (1999)
  • Published: 30/01/2012
  • Volume: 60
  • Issue: 1
  • Pagination: 20-23


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