Publications & Reports

Adverse effects of amphotericin B in children; a retrospective comparison of conventional and liposomal formulations.

Andrew EC, Curtis N, Coghlan B, Cranswick N, Gwee A
Infectious Diseases and Clinical Pharmacology Units, The Royal Childrenaposs Hospital Melbourne, Parkville, Victoria, Australia.

Abstract

AIM: Lipid formulations of amphotericin B, rather than conventional amphotericin (c-amB), are increasingly used despite limited data comparing these preparations in children. Data on the incidence of adverse effects with amphotericin-B at standard doses are scarce. This study aimed to compare the adverse effects associated with standard doses of c-amB and liposomal amphotericin (l-amB) in children. METHODS: Children admitted to the Royal Childrenaposs Hospital Melbourne and treated with c-amB or l-amB between January 2010 and September 2013 were included. Clinical and laboratory data were retrospectively extracted from medical records to compare amphotericin-related infusion reactions, nephrotoxicity (glomerulotoxicity and tubulopathy) and hepatotoxicity. RESULTS: Seventy-six children received c-amB and 39 received l-amB. Standard drug administration (recommended dose and infusion time) occurred in 74% (56/76) on c-amB and 85% (33/39) on l-amB. In these 89 children, infusion-related reactions were similar with c-amB than l-amB (23% (13/56) vs. 9% (3/33); p=0.15); none occurred in children aged <90 days. There was no difference in amphotericin-associated glomerulotoxicity (c-amB 14% (8/56) vs l-amB 21% (7/33); p=0.40) or in median maximum potassium requirements (c-amB 3.1 vs l-amB 2.3 mmol/kg/d; p=0.29). Hepatotoxicity occurred more frequently with l-amB than c-amB (83% (24/29) v. 56% (20/36); p=0.032). CONCLUSIONS: When appropriately administered, l-amB was associated with more hepatotoxicity than c-amB, with no difference in infusion-related reactions or nephrotoxicity. Differences in adverse effects between the preparations is not be as marked in children as reported in adults.

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Publication

  • Journal: British Journal of Clinical Pharmacology
  • Published: 19/01/2018
  • Volume: 84
  • Issue: 5
  • Pagination: 1006-1012

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