Nonnucleoside reverse transcriptase inhibitors reduce HIV-1 virus production from latently infected resting CD4+ T cells following latency reversal.
Zerbato JM, Tachedjian G, Sluis-Cremer N
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Abstract
Therapeutic strategies that target the latent HIV-1 reservoir in resting CD4+ T cells of infected-individuals are always administered in the presence of combination antiretroviral therapy. Using a primary cell of HIV-1 latency, we evaluated whether different antiviral drug classes affected latency reversal (as assessed by extracellular virus production) by anti-CD3/CD28 monoclonal antibodies or by bryostatin 1. We found that the nonnucleoside reverse transcriptase inhibitors efavirenz and rilpivirine significantly decreased HIV-1 production by ≥ 1 log.
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