Publications & Reports

Toll-like receptors in hepatitis C infection: implications for pathogenesis and treatment.

Jessica Howell, Peter Angus, Paul Gow, Kumar Visvanathan
Liver Transplant Unit, Austin Hospital, Victoria, Australia. [email protected]

Abstract

Hepatitis C virus (HCV) infection is a significant global health problem, affecting over 150 million people worldwide. While the critical role of the adaptive immune system in HCV infection is well-established, the importance of the innate immune system in HCV infection has only been recognized in more recent years. Toll-like receptors form the cornerstone of the innate immune response, and there is considerable evidence for their crucial role in hepatitis C infection. This review outlines recent advances made in our understanding of the role of Toll-like receptor function in HCV infection, exploring how HCV manipulates host immunity to evade immune clearance and establish persistent infection despite leading to inflammatory hepatic damage.

Publication

  • Journal: Journal of Gastroenterology and Hepatology
  • Published: 01/05/2013
  • Volume: 28
  • Issue: 5
  • Pagination: 766-776

Author

Health Issue