Publications & Reports

Mechanisms of HIV transmission in Depo-Provera users: The likely role of hypoestrogenism.

Hickey M, Marino JL, Tachedjian G


AB Almost half of new HIV infections worldwide occur in women, and vaginal intercourse is the most common mode of transmission. Accumulating evidence suggests that depot medroxyprogesterone acetate (DMPA, Depo-Provera) may increase HIV transmission, but little is known about the underlying mechanisms. We propose that hypoestrogenism in DMPA may contribute to increased HIV transmission. We present supportive evidence and propose potential interventions to prevent or treat vaginal hypoestrogenism using vaginal estrogens.


  • Journal: Journal of Acquired Immune Deficiency Syndrome
  • Published: 01/01/2016
  • Volume: 71
  • Issue: 1
  • Pagination: 1-7


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