Publications & Reports

Role of education and differentiation in determining the potential of natural killer cells to respond to antibody-dependent stimulation.

Parsons MS, Loh L, Gooneratne S, Center RJ, Kent SJ
aDepartment of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne bBurnet Institute, Melbourne cMelbourne Sexual Health Centre, Carlton, Victoria, Australia.

Abstract

Antibody-dependent activation of natural killer (NK) cells might facilitate protective outcomes in the context of HIV exposure or infection. Antibody-dependent activation is heightened in NK cells educated by interactions between killer immunoglobulin-like receptors (KIRs) and their major histocompatibility complex class I ligands during ontogeny. Differentiated NK cells, defined as CD57, also exhibit enhanced antibody-dependent responsiveness. Although KIRs are more frequently expressed on CD57 NK cells, the presented data suggest education and differentiation make independent contributions to NK cell anti-HIV envelope antibody-dependent activation.

Full text version of manuscript available at link at lower right of this page. Publisher’s final version of article is at http://journals.lww.com/aidsonline/pages/articleviewer.aspx?year=2014&issue=11280&article=00017&type=abstract

Publication

  • Journal: AIDS
  • Published: 28/11/2014
  • Volume: 28
  • Issue: 18
  • Pagination: 2781-2786

Author

Health Issue

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