Publications & Reports

Plasmodium falciparum and Plasmodium vivax genotypes and efficacy of intermittent preventive treatment in Papua New Guinea.

Barnadas C, Senn N, Iga J, Timinao L, Javati S, Malau E, Rarau P, Reeder JC, Siba P, Karunajeewa H, Zimmerman PA, Davis TM, Mueller I
Vector Borne Diseases Unit, Papua New Guinea Institute of Medical Research (PNGIMR), Goroka, Papua New Guinea Infection and Immunity Division, Walter & Eliza Hall Institute of Medical Research, Parkville, Australia Department of Medical Biology, Universit

Abstract

Intermittent preventive treatment of infants (IPTi) reduces early-childhood malaria-related morbidity. While genotypic drug resistance markers have proven useful in predicting the efficacy of antimalarial drugs in case management, there are few equivalent data relating to their protective efficacy when used as IPTi. The present data from an IPTi trial in Papua New Guinea demonstrate how these markers can predict protective efficacy of IPTi for both Plasmodium falciparum and vivax.

Publication

  • Journal: Antimicrobial Agents and Chemotherapy
  • Published: 25/08/2014
  • Volume: 58
  • Issue: 11
  • Pagination: 6958-6961

Health Issue

Download